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Digitale Medien

Protoanemonin Detection in Caltha palustris (1986)

Bruni, A. ; Bonora, A. ; Dall'Olio, G.

s.l. : American Chemical Society

Journal of natural products 49 (1986), S. 1172-1173

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ISSN: 1520-6025

Quelle: ACS Legacy Archives

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1021/np50048a058

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Digitale Medien

Phospholipids in inflammatory synovial effusions (1986)

Punzi, L. ; Todesco, S. ; Toffano, G. ; [weitere]

Springer

Rheumatology international 6 (1986), S. 7-11

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ISSN: 1437-160X

Schlagwort(e): Phospholipids ; Phospholipase A2 ; Synovial fluid ; Inflammation ; Arthritis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The concentration of phospholipids and proteins was determined in 23 inflammatory synovial fluids obtained from human knee joints. The synovial fluid to plasma phospholipid ratio (0.48 and 0.37 at high and low inflammatory state) was lower than the value found for the total protein content (0.68 and 0.53, respectively) indicating that phospholipids were more discriminated than proteins in their transfer from plasma to the synovial space. Constant amounts of phosphatidylinositol were found in all synovial fluids, whereas trace amounts of lysophosphatidylethanolamine and phosphatidylserine were more frequent in the active inflammatory state. A decrease in the relative amounts of phosphatidylcholine and phosphatidylinositol with respect to plasma suggested the possibility of phospholipid hydrolysis in the synovial compartment. In agreement, determinations of phospholipase activity disclosed the presence of a phospholipase A2 in the fluid phase of synovial effusions. Phospholipid derivatives formed in the synovial space may thus contribute to the amplification of the inflammatory response.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00270658

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Digitale Medien

Characterization of macrophages elicited by intraperitoneal injection of hyaluronate (1986)

Ponzin, D. ; Vecchia, P. ; Toffano, G. ; [weitere]

Springer

Inflammation research 18 (1986), S. 544-549

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ISSN: 1420-908X

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Hyaluronate of 120,000 molecular weight has been injected in the peritoneal cavity of mice to study its effect on migration of inflammatory cellsin vivo. After one day a dosedependent granulocyte migration is observed. Three days later the number of granulocytes is greatly reduced and macrophages form about half of the total cell population. Hyaluronateelicited macrophages show a decreased 5′-nucleotidase and an increased acid phosphatase activity as compared to resident macrophages. The production of superoxide anion in response to the phorbol ester tetradecanoyl-phorbolacetate, and the phagocytic activity are also enhanced. Macrophages elicited by hyaluronate secrete growth factor(s) for non-lymphoid mesenchymal cells. It is concluded that hyaluronatein vivo stimulates the migration of inflammatory cells, thus causing the recruitment of a population of stimulating macrophages. These effects may explain previous reports on the acceleration of wound healing by hyaluronate.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01964962

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