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  • 1985-1989  (2)
  • 1955-1959
  • 1986  (2)
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  • 1985-1989  (2)
  • 1955-1959
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 62 (1986), S. 572-578 
    ISSN: 1432-1106
    Keywords: Vasopressin cell ; Noxious input ; Hypovolemia ; Supraoptic nucleus ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of saphenous nerve stimulation on discharge activity of supraoptic neurosecretory (NS) cells were studied in anesthetized rats. Of 112 supraoptic neurosecretory cells, 62 exhibited a ‘phasic’ discharge pattern. The nerve stimulation transiently excited 46 of these 62 ‘phasic’ units, as well as 35 of the 50 remaining ‘non-phasic’ units. No appreciable blood pressure change was noted using PSTHs with 1-ms resolution. Though the nerve stimulation also evoked a flexor reflex of the ipsilateral hind limb, blockage of the hind limb movement with gallamine did not alter the amplitude of the supraoptic cell excitation. The threshold of the nerve stimulation was higher for the excitation than for the flexor reflex. Effects of hypovolemic and hyperosmotic stimuli on discharge activity of ‘phasic’ cells during saphenous nerve stimulation were studied to find a possible interaction between these stimuli. Hemorrhage potentiated the transient excitation evoked by the nerve stimulation in all of the 8 ‘phasic’ cells tested, while no such effect was seen after an injection of hypertonic sodium chloride solution in the 7 ‘phasic’ cells tested. These electrophysiological data suggest that hypovolemic and noxious stimuli potentiate VP secretion in a synergistic manner but that hyperosmotic and noxious stimuli do not.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seroepidemiological studies of hemorrhagic fever with renal syndrome (HFRS) virus infection were carried out among urban rats(Rattus norvegicus andRattus rattus) and small field rodents in Hokkaido, Japan. An urban rat colony that was seropositive to SR-11 strain of HFRS virus (laboratory rat origin) was demonstrated in February 1983 at a dumping ground area of Kami-iso Town near Hakodate port. An HFRS-related virus, named KI-262 strain, was isolated from the lung tissue of a seropositive rat using Vero-E6 cell culture. Antigenicity of the isolate was closely related to Hantaan 76–118 and SR-11 strains by the indirect immunofluorescent antibody (IFA) test. No seropositive rat was found among the 861 rats captured in 38 other regions. It is unclear whether or not the infected rats in the positive area were introduced from abroad, though the area is located near Hakodate International Port. Furthermore, higher positive rates of urban rats in the Kami-iso area were observed in the spring and winter than in the summer and fall. Significantly high proportion of positive cases was observed among adult rats (six months or older) than among younger animals. The seasonal and age distribution of postive cases suggested that the virus was not readily transmitted from one infected rat to another. One seropostive case of a small field mouse(Clethrionomys rufocanus bedfordiae) was detected around the Kami-iso area.
    Type of Medium: Electronic Resource
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