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  • 1990-1994  (5)
  • 1965-1969
  • 1990  (5)
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  • 1990-1994  (5)
  • 1965-1969
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Acute toxic effect of sodium dichromate on metabolism (1990)
    Springer
    Archives of toxicology 64 (1990), S. 644-649 
    Details
    ISSN: 1432-0738
    Keywords: Sodium dichromate ; Glycolysis ; Hyperglycemia ; Glycogenolysis ; Cyanosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of sodium dichromate on cellular metabolism was investigated. Intraperitoneal injection of sodium dichromate into the rat (20 or 40 mg/kg) caused significant increases in serum lactate, pyruvate, and creatinine concentrations within 15 min after intoxication. Severe hyperglycemia occurred thereafter, as a result of increased hepatic glycogenolysis, which was seen in the first 2 h after dichromate. However, liver glycogen was resynthesized in 24 h-fasted rats after glucose refeeding. Dichromate decreased serum total amino acids, with a consequent increase in blood urea nitrogen (BUN) concentration. Unlike HgCl2 (2 mg/kg, i.p.), As2O3 (5 mg/kg, i.p.), and KCN (5 mg/kg, i. p.), dichromate showed the largest metabolic disturbance only in the early period after treatment. In addition, dichromate produced cyanosis, which appeared during the period of the accelerated glycolysis and breakdown of creatine phosphate. Regardless of chemical species, only the hexavalent chromium compounds had an effect on the cellular metabolism. Trivalent chromium compounds had no effect at all. These results suggest that dichromate possesses a characteristic dual action on cellular metabolism, which might be related to its metabolic fate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01974692
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Phase resetting dynamics for a discrete reaction–diffusion model (1990)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 92 (1990), S. 7315-7322 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The results of a study of spatial pattern formation in a two-dimensional oscillatory reaction–diffusion system are presented. The calculations are carried out on a discrete model of the Brusselator reaction. The system responds to inhomogeneous perturbations in two different ways. For most perturbations it relaxes back to a spatially homogeneous state with a phase shift. However, special perturbations produce persistent structures which consist of spiral waves and target patterns. The nature of these spatio-temporal states is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.458216
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Inhomogeneous perturbations and phase resetting in an oscillatory reaction–diffusion system (1990)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 92 (1990), S. 7302-7314 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The response of the Brusselator reaction–diffusion system to inhomogeneous perturbations is studied. The main focus of this work is on a spatial generalization of the phase resetting problem. A randomly chosen fraction p of an initially homogeneous oscillatory system is locally perturbed and driven off the limit cycle. The asymptotic local phase is monitored and averaged over local regions and realizations of the perturbation process. From this information a phase response curve can be constructed which depends both on the local stimulus amplitude and on p. The system exhibits two qualitatively different kinds of response depending on the stimulus amplitude and the phase at which the perturbation is applied. It either relaxes to a spatially homogeneous oscillatory state or develops persistent spatial patterns. The origin of this behavior is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.458215
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Microbial products. 9. Roxaticin, a new oxo pentaene antibiotic [Erratum to document cited in CA111(21):191083x] (1990)
    s.l. : American Chemical Society
    The @journal of organic chemistry 55 (1990), S. 3704-3704 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00298a071
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Induction of high-grade anti-tumor immunity by use of a recombinant H-2Kb/avian erythroblastosis virus erbB gene transfectant (1990)
    Springer
    Cancer immunology immunotherapy 31 (1990), S. 115-120 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The recombinant H-2Kb-erbB gene, encoding for a part of the H-2 class I antigen and the kinase domain of the V-erbB peptide, was successfully introduced into murine mastocytoma P815 variant P1.HTR cells, which resulted in low but significant cell-surface expression of the hybrid gene product. When the chimeric gene transfectant was inoculated into the CDF1 mice, it soon grew but regressed thereafter. The tumorigenicity of this transfectant was lower than the H-2Kb gene transfectant that expressed the H-2Kb antigen at a comparable level. These CDF1 mice that had received the chimeric gene transfectant obtained a high-grade anti-tumor immunity against the challenge of a high dose of parental tumor. Corresponding to these observations, anti-tumor cytotoxic T lymphocytes, which lyse parental P1.HTR cells but not syngeneic L1210 or NS-1 tumor cells, were developed in the peritoneal cavity of mice that had been inoculated with the transfectant and parental tumor. Definite antibody activity binding to parental P1.HTR tumor cells was also demonstrated in the sera of these mice, precipitating 40-kDa, 74-kDa and 98-kDa molecules from the surface of the radiolabeled P1-HTR tumor cells. The results suggested that the chimeric H-2-erbB gene transfectant efficiently triggers both cellular and humoral anti-tumor immune responses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01742375
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    Paper (German National Licenses)
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