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  • 1990-1994  (2)
  • 1990  (2)
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  • 1990-1994  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Chronic lithium administration enhances serotonin release in the lateral hypothalamus but not in the hippocampus in rats. A microdialysis study (1990)
    Springer
    Journal of neural transmission 82 (1990), S. 31-41 
    Details
    ISSN: 1435-1463
    Keywords: Lithium ; 5-HT ; release ; microdialysis ; rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Chronic administration of lithium displays therapeutic and prophylactic effects in bipolar affective disorders, but its mechanism of action remains unknown. Several studies in animals and humans strongly suggest that central serotonergic neurons might be involved in lithium effects. In the experiments reported here microdialysis with removable probes and high pressure liquid chromatography and electrochemical detection were used to assess the amphetamine-induced release of serotonin (5-HT) and the 5-hydroxy-indoleacetic acid (5-HIAA) levels in the perifornical hypothalamus (PFH) and hippocampus (HP) of freely moving rats before and after chronic lithium chloride administration (2 meq/kg, as intragastric daily injections for 14 days). The serum lithium levels were 0.66 ± 0.08 meq/1. After lithium treatment, the amphetamine-induced 5-HT release was significantly enhanced in the PFH but not so in the HP. Basal levels of 5-HIAA in the control group decreased but remained unchanged in the lithium group in the PFH. No change of basal levels of 5-HIAA was observed in the HP. The effect of lithium on the PFH could be related to the improvement of the autonomic and cyclic symptoms of patients with manic depressive disorders undergoing lithium therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244832
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Speciation of tetraalkyllead compounds by flow injection — atomic absorption spectrophotometry (1990)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 338 (1990), S. 9-15 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The on-line demetallation of alkyllead compounds, with iodine, and further emulsification, provides a fast determination of total lead content in liposoluble matrices, such as gasolines. It can be carried out in a double channel manifold, using a magnetically well stirred dilution chamber for the emulsification of the samples, previous to their analysis by flame atomic absorption spectrophotometry. On the other hand, the different behaviour of tetraethyllead (TEL) and tetramethyllead (TML) can be employed for speciation of both compounds in the sample. The effect of the flow injection parameters on the sensitivity and accuracy has been studied and the figures of merit of the proposed methods evaluated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00322776
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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