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Comparative efficacy of drug regimens in skin tuberculosis (1991)

RAMESH, V. ; MISRA, R.S. ; SAXENA, U. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Clinical and experimental dermatology 16 (1991), S. 0

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ISSN: 1365-2230

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Three antituberculous drug regimens have been employed to study the therapeutic response in 90 patients with any one of the commonly encountered paucibacillary forms of skin tuberculosis, namely lupus vulgaris, tuberculosis verrucosa cutis and scrofuloderma. The first two regimens contained rifampicin, isoniazid and either pyrazinamide or thiacetazone, and the third regimen had rifampicin and isoniazid only. The disease was clinically defined as localized when confined to one area and widespread when the lesions were disseminated. The observations revealed that the response of lupus vulgaris and tuberculosis verrucosa cutis was alike in all the three regimens, with the localized lesions subsiding completely after 4 months of therapy and the more extensive forms taking 5 months. Patients with scrofuloderma responded similarly to both the triple drug regimens. The discharge, sinuses and ulcers cleared in 6 months but the lymph nodes took longer to regress, up to 7 months in localized and 9 months in more widespread scrofuloderma. To obtain the same results with rifampicin and isoniazid, all patients with widespread scrofuloderma and one-third of those with localized forms had to be treated for 10 and 9 months, respectively. No serious drug side-effects, apart from giddiness with rifampicin and acneiform eruptions with thiacetazone, were encountered. No instances of relapse were noted in the 50% of patients who were followed-up for 31/2 years after therapy. Single-drug therapy with isoniazid for lupus vulgaris, as given in the past, is to be discouraged as it may promote the emergence of drug-resistant bacilli in those with an undetected focus of infection. An additional object of defining effective mutliple drug regimens is to improve patient compliance by reducing the duration of therapy and to avoid confusion by adhering uniformly to the recommended regimen in places where tuberculosis is prevalent.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2230.1991.tb00317.x

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Industrial emissions of mercury in Finland between 1967 and 1987 (1991)

Mukherjee, A. B.

Springer

Water, air & soil pollution 56 (1991), S. 35-49

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ISSN: 1573-2932

Source: Springer Online Journal Archives 1860-2000

Topics: Energy, Environment Protection, Nuclear Power Engineering

Notes: Abstract Mercury pollution has been studied in Finland since 1960. In the 1960 's, industrial use of Hg was about 50 t yr−1, 80% of which was consumed by chlor-alkali plants. In the 1980's, about 19, to 25 t yr−1 Hg was used and compared to past consumption, its use has decreased by 40 to 50%. In 1987, the import of Hg through raw materials and other sources in Finland was, however about 170 t yr−1 which is rather high. There are no detailed statistics about Hg emissions in the 1960's. In 1967, air and water emissions of Hg were 2.8 and 8.3 t yr−1 respectively. In 1987, estimated air emission of Hg was 3.48 t yr−1 whereas water emission was 0.15 t yr−1 Aquatic emission has been lowered by 50% which is due to the fact that pulp and paper industries stopped using Hg as slimicide. On the other hand, the air emission of Hg has not decreased. This is due to the high Hg content in raw materials used by metallurgical and power plants.