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Digitale Medien

Sequence and functional analysis of the cloned Neisseria meningitidis CMP-NeuNAc synthetase (1992)

Edwards, Ulrike ; Frosch, Matthias

Oxford, UK : Blackwell Publishing Ltd

FEMS microbiology letters 96 (1992), S. 0

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ISSN: 1574-6968

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Biologie

Notizen: Abstract The CMP-N-acetylneuraminic acid (CMP-NeuNAc) synthetase gene of Neisseria meningitidis group B is located on a 2.3-kb EcoRI fragment within the cps gene cluster. Nucleotide sequence determination of the gene encoding the CMP-NeuNAc synthetase revealed a 515-bp open reading frame that can encode a 18.9-kDA protein. A computer data base scan revealed a 59.4% identity to the CMP-NeuNAc synthetase gene of E. coli K1. Enzymatic activity was confirmed in vitro and in vivo. Transformation of the CMP-NeuNAc defective E. coli K1 strain EV5 with the meningococcal CMP-NeuNAc synthetase could complement the defect in E. coli.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1574-6968.1992.tb05410.x

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Digitale Medien

Transformation-mediated exchange of virulence determinants by co-cultivation of pathogenic Neisseriae (1992)

Frosch, Matthias ; Meyer, Thomas F.

Oxford, UK : Blackwell Publishing Ltd

FEMS microbiology letters 100 (1992), S. 0

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ISSN: 1574-6968

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Biologie

Notizen: Abstract The horizontal flow of genetic material between microbes utilizes three principal routes: conjugation, transduction and transformation. While the significance in nature of the first two pathways is generally accepted, the in vivo role of transformation remains uncertain, despite the early observations by Griffith in 1928 on the transformation of streptococci from an avirulent to a virulent state [1]. Recently, circumstantial evidence was collected suggesting a role for transformation-mediated horizontal exchange in the modulation of virulence determinants of pathogenic Neisseriae and the variation of surface structures. In order to further assess the significance of transformation-mediated exchange we performed simple co-cultivation experiments of different Neisseria strains. We observed an efficient intra- and interspecies transfer of essential virulence determinants; the process was sensitive to the presence of DNaseI in the culture and was blocked in transformation-deficient recipients.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1574-6968.1992.tb14062.x

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Digitale Medien

Measurements of the muon-neutrino mass (1992)

Daum, M. ; Frosch, R. ; Herter, D. ; [weitere]

Springer

The European physical journal 56 (1992), S. S114

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ISSN: 1434-6052

Quelle: Springer Online Journal Archives 1860-2000

Thema: Physik

Notizen: Abstract The most precise upper limits for the muon-neutrino mass $$m_{v_\mu }$$ have been obtained by measuring the muon momentump μ + in pion decayπ +→μ+ v μ at rest. The current result for the squared neutrino mass, $$m_{v_\mu } ^2 = - 0.154 \pm 0.045MeV^2$$ , negative by 3.4 standard deviations, indicates that the experimental value for at least one of the three quantities used in the $$\left( {m_{v_\mu } ^2 } \right) -$$ derivation (p μ +,m π+,m μ+) is wrong.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02426784

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