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  • 1
    Electronic Resource
    Electronic Resource
    Corticobasal degeneration: a disease with widespread appearance of abnormal tau and neurofibrillary tangles, and its relation to progressive supranuclear palsy (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 113-121 
    Details
    ISSN: 1432-0533
    Keywords: Key words: Corticobasal degeneration ; Progressive ; supranuclear palsy ; Neurofibrillary tangles ; Abnormal tau
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The neuropathological findings, including immunohistochemistry and electron microscopy, of two patients with clinical findings consistent with corticobasal degeneration (CBD) are reported. Both patients showed degeneration of the precentral cortex, the substantia nigra, the pallidum, and the thalamus. Many ballooned neurons were seen in the cerebral cortex, and argentophilic, skein-like inclusions suggesting neurofibrillary tangles (NFTs) were found in the brain stem and precentral cortex in patient 1. In contrast, patient 2 clearly showed NFTs in the brain stem and dentate nucleus which were indistinguishable from those seen in progressive supranuclear palsy (PSP), while only a few ballooned neurons were found in the cerebral cortex. Gallyas silver stain showed many argentophilic inclusions suggesting NFTs in the brain stem, subcortical nuclei, and cerebral cortex in both patients. Immunohistochemistry for tau showed tau-positive neurons in the cerebral cortex, brain stem, subcortical nuclei and spinal cord, and tau-positive glial cells were seen in the cerebral cortex, white matter and subcortical nuclei, and thread-like structures were seen in the cerebral cortex and white matter. Electron microscopy of the brain stem showed NFTs consisting of paired helical filaments in patient 1, and paired helical filaments and straight tubules in patient 2. Immunoelectron microscopy revealed parallel tau-positive filaments in the cerebral cortex in patent 1. From the two patients, the widespread appearance of abnormal tau and NFTs is one of the essential pathological features in CBD, and it also appears that CBD and PSP have some common underlying pathological processes. Patient 2 is closer to PSP than patient 1 and suggests CBD would link to PSP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294503
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  • 2
    Electronic Resource
    Electronic Resource
    An α-fetoprotein producing pancreatic cystadenocarcinoma (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 377-380 
    Details
    ISSN: 1432-1440
    Keywords: Mucinous cystadenocarcinoma ; Pancreas ; α-Fetoprotein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An autopsy case of an 83-year-old Japanese woman with pancreatic cancer with significantly elevated serum α-fetoprotein levels is reported. The pancreatic tumor was a mucinous cystadeno-carcinoma with multiple metastasis to the liver. The immunohistochemistry for α-fetoprotein revealed positive reactivity in the cytoplasm of cancer cells in the primary and liver metastatic lesions. The current case is the first reported in which mucinous cystadenocarcinoma of the pancreas produced α-fetoprotein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252831
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    InAlAs/InGaAs metal-semiconductor-metal photodiodes heteroepitaxially grown on Si substrates (1994)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 64 (1994), S. 751-753 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: To study performance and reproducibility of photodiodes (PDs) on Si in the long-wavelength region, InAlAs/InGaAs metal-semiconductor-metal PDs were fabricated on high-quality heteroepitaxial InP layers on Si substrates. A dark current of 0.5–2×10−8 A and a responsivity of 0.05–0.15 A/W were reproducibly obtained, at least at one of the ±5 V bias voltages. These dark currents and responsivity are similar to those of PDs with the same structure fabricated on InP substrates. The PDs on Si have pulse responses with full widths at half-maximum of 150–600 ps.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.111055
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Corticobasal degeneration: a disease with widespread appearance of abnormal tau and neurofibrillary tangles, and its relation to progressive supranuclear palsy (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 113-121 
    Details
    ISSN: 1432-0533
    Keywords: Corticobasal degeneration ; Progressive supranuclear palsy ; Neurofibrillary tangles ; Abnormal tau
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The neuropathological findings, including immunohistochemistry and electron microscopy, of two patients with clinical findings consistent with corticobasal degeneration (CBD) are reported. Both patients showed degeneration of the precentral cortex, the substantia nigra, the pallidum, and the thalamus. Many ballooned neurons were seen in the cerebral cortex, and argentophilic, skein-like inclusions suggesting neurofibrillary tangles (NFTs) were found in the brain stem and precentral cortex in patient 1. In contrast, patient 2 clearly showed NFTs in the brain stem and dentate nucleus which were indistinguishable from those seen in progressive supranuclear palsy (PSP), while only a few ballooned neurons were found in the cerebral cortex. Gallyas silver stain showed many argentophilic inclusions suggesting NFTs in the brain stem, subcortical nuclei, and cerebral cortex in both patients. Immunohistochemistry for tau showed tau-positive neurons in the cerebral cortex, brain stem, subcortical nuclei and spinal cord, and tau-positive glial cells were seen in the cerebral cortex, white matter and subcortical nuclei, and thread-like structures were seen in the cerebral cortex and white matter. Electron microscopy of the brain stem showed NFTs consisting of paired helical filaments in patient 1, and paired helical filaments and straight tubules in patient 2. Immunoelectron microscopy revealed parallel tau-positive filaments in the cerebral cortex in patent 1. From the two patients, the widespread appearance of abnormal tau and NFTs is one of the essential pathological features in CBD, and it also appears that CBD and PSP have some common underlying pathological processes. Patient 2 is closer to PSP than patient 1 and suggests CBD would link to PSP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294503
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Serial neuroradiological studies in focal cerebritis (1994)
    Springer
    Neuroradiology 36 (1994), S. 285-288 
    Details
    ISSN: 1432-1920
    Keywords: Cerebritis ; Brain abscess ; MRI ; CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report serial neuroradiological studies in a patient with focal cerebritis in the head of the left caudate nucleus. On the day after the onset of symptoms, CT showed an ill-defined low density lesion. The lack of contrast enhancement appeared to be the most important finding for differentiating focal cerebritis from an encapsulated brain abscess or a tumour. MRI two days later revealed the centre of the lesion to be of slightly low intensity on T1-weighted inversion recovery (IR) images and very low intensity on T2-weighted spin echo images, which appeared to correspond to the early cerebritis stage of experimentally induced cerebritis and brain abscess. Ten days after the onset of symptoms, CT revealed a thin ring of enhancement in the head of the caudate nucleus, and a similar small ring was seen in the hypothalamus 16 days after the onset, corresponding to the late cerebritis stage. MRI nine days later revealed ill-defined high signal lesions within the involved area on the T1-weighted IR images. To our knowledge, this is the first published MRI documentation of the early cerebritis stage developing into an encapsulated brain abscess. The mechanisms underlying of these radiographic changes are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593261
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Detection of manganese superoxide dismutase mRNA in the theca interna cells of rat ovary during the ovulatory process by in situ hybridization (1994)
    Springer
    Histochemistry and cell biology 102 (1994), S. 173-176 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract To determine the possible involvement of reactive oxygen species in ovulation, dynamic aspects of superoxide dismutase (SOD) isozyme were studied in the ovaries of rats by in situ hybridization histochemistry. Previously, mRNA levels of ovarian manganese superoxide dismutase (Mn-SOD) were reported markedly to increase whilst enzymic activity of Mn-SOD decreased during the ovulatory process after treating immature rats with 10 and 5 Units, respectively, of pregnant mare serum gonadotrophin (PMSG) and human chorionic gonadotrophin (HCG). Levels of Cu/Zn-SOD activity and Cu/Zn-SOD mRNA were reported to remain unchanged throughout ovulation. This increase in the Mn-SOD mRNA level was shown in the present study by in situ hybridization to be localized to the theca interna cells throughout the PMSG/HCG-induced ovulatory process. The observations suggest that the turnover rate of Mn-SOD but not Cu/Zn-SOD increases specifically in the mitochondria of these cells. SOD has been postulated to play important roles in steroidogenesis. The relationship is discussed between mitochondrial functions in steroid-secreting cells and superoxide radicals and related metabolite(s).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00268893
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of laser induced crystallization of semiconductor particle CdS x Se1−x in glass matrix on reflectivity of phase-conjugated signal (1994)
    Springer
    Journal of materials science 13 (1994), S. 1727-1728 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451754
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  • 8
    Electronic Resource
    Electronic Resource
    Cluster-size dependence of alloying behavior in gold clusters (1994)
    Springer
    The European physical journal 31 (1994), S. 131-134 
    Details
    ISSN: 1434-6079
    Keywords: 61.16.Di ; 36.40.+d ; 66.30.−h
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Cluster-size dependence of alloying behavior in nm-sized atom clusters has been studied by transmission electron microscopy, using clusters in the Au-Cu system. It was revealed that occurrence of rapid spontaneous alloying becomes more difficult with increasing cluster size. In gold clusters of approximately 4 nm in the mean size, a rapid dissolution of copper atoms took place and homogeneously mixed Au-Cu alloy clusters were formed. In gold clusters of approximately 10 nm in the mean size, rapid alloying of copper took place only at a shell-shaped region beneath the free surface of individual clusters and pure gold was retained at the central region of clusters. In gold clusters of approximately 30 nm in the mean size, no rapid alloying of copper was induced. The ease with which spontaneous alloying takes place is discussed in terms of the lattice softening in atom clusters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01426588
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  • 9
    Electronic Resource
    Electronic Resource
    Structure of nm-sized InSb clusters formed by spontaneous alloying (1994)
    Springer
    The European physical journal 31 (1994), S. 209-212 
    Details
    ISSN: 1434-6079
    Keywords: 61.16.Di ; 36.40. + d ; 66.30. − h
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The alloying behavior of antimony atoms into nm-sized indium clusters has been studied in situ by TEM. When antimony atoms are vapor-deposited onto nm-sized indium clusters, a rapid dissolution of antimony atoms into indium clusters takes place and as a result InSb compound clusters are successfully formed. Such spontaneous alloying occurs even at ambient temperature. InSb clusters thus formed have the wurtzite structure. When these InSb clusters are annealed at 533 K, their structure changes into the sphalerite structure, which is the structure of the equilibrium phase of the bulk In50Sb50. The appearance of wurtzite-type InSb by spontaneous alloying is discussed in terms of ionicity of bonds in InSb.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01437838
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