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  • 1995-1999  (80)
  • 1905-1909
  • 1997  (80)
  • 1
    Digitale Medien
    Digitale Medien
    A minor groove binding track in reverse transcriptase (1997)
    [s.l.] : Nature Publishing Group
    Nature structural biology 4 (1997), S. 194-197 
    Details
    ISSN: 1072-8368
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Medizin
    Notizen: [Auszug] Proteins that bind with high affinity to specific DNA sequences often do so through hydrogen bonding and electrostatic interactions between the DNA major groove and defined protein structural elements, such as helix-turn-helix motifs, β-ribbon recognition elements and Zn-binding domains1. ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/nsb0397-194
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  • 2
    Digitale Medien
    Digitale Medien
    On the conformation of non-adsorbing polymers in colloidal suspensions (1997)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 107 (1997), S. 7502-7511 
    Details
    ISSN: 1089-7690
    Quelle: AIP Digital Archive
    Thema: Physik , Chemie und Pharmazie
    Notizen: This paper investigates the interaction of dilute polymer solution with a colloidal suspensions. The object of consideration is the effective monomer–monomer potential between different polymer pieces. Unlike in the current polymer literature the effective potential is calculated beyond the pseudo potential approximation, i.e., detailed effects of the colloidal liquid is taken into account. It is shown that the effective potential can be used to discuss the stability of the three component system, polymer chains, good solvent, and colloidal particles. The latter are approximated as hard spheres. Two regimes are found: The polymer chains are collapsed (as a function of the packing fraction of the colloids), if the size of the polymer is much larger compared to the colloids. This corresponds to the unstable regime. If the polymer chains are smaller, it is shown that the depletion effect dominates the physical behavior and the solution is stable. Detailed criteria are worked out in the form of an eigenvalue equation for the interactions and conformations. © 1997 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.474990
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  • 3
    Digitale Medien
    Digitale Medien
    The Construct of Mental Disorder (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical psychology 4 (1997), S. 0 
    Details
    ISSN: 1468-2850
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Psychologie
    Notizen: Bergner expresses well the fundamental issues and principal difficulties in defining the construct of mental disorder. However, it is unlikely that the definition by Ossorio that Bergner advocates will prove to be any more successful than prior efforts. Discussed briefly within this commentary are three issues: (a) the absence of an operational definition for a theoretical construct, (b) the absence of a distinct boundary either with physical disorders or with normality for the construct of mental disorder, and (c) the impact of values and culture. These issues are fundamental and substantial. Nevertheless, it is argued that the construct of mental disorder (as an involuntary organismic impairment in psychological functioning) does have substantial validity as a scientific construct.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1468-2850.1997.tb00115.x
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  • 4
    Digitale Medien
    Digitale Medien
    Controlled morphology of biologically derived metal nanopatterns (1997)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 71 (1997), S. 1264-1266 
    Details
    ISSN: 1077-3118
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: We report the ability to control the morphology of nanometer thick Ti oxide films that were created via a parallel nanofabrication process using a two-dimensional protein crystal as a template. Atomic force microscopy was used to examine the evolution of these structures from a periodic array of nanometer-scale dots (nanodots) to a screen containing a periodic array of nanometer-scale holes (nanoscreen) as the film thickness was increased. A Monte Carlo solid-on-solid simulation was then developed to explain the thickness dependence of the morphology as the metal film self-organizes into these nanopatterns. © 1997 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.119868
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  • 5
    Digitale Medien
    Digitale Medien
    Mortgage Default in Local Markets (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Real estate economics 25 (1997), S. 0 
    Details
    ISSN: 1540-6229
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Wirtschaftswissenschaften
    Notizen: Using recent theoretical advances and an extensive panel data set on metropolitan areas, this study provides new tests of the contingent claims based model of default. The empirical modeling incorporates a full complement of variables that permit direct tests of the options-based model including the conditional effects of age and rent-to-price ratios. The role of transaction costs and trigger events is examined, and the results confirm the importance of both. The effects of aggregation and short sample periods are explored and demonstrated to affect inference in studies of mortgage default.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/1540-6229.00731
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  • 6
    Digitale Medien
    Digitale Medien
    Vibration, Acceleration, Gravitation, and Movement: Activity Controlled Rate Adaptive Pacing During Treadmill Exercise Testing and Daily Life Activities (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 20 (1997), S. 0 
    Details
    ISSN: 1540-8159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Activity-based sensors for rate adaptive pacing have been available for several years and now include several different types: vibration; acceleration; gravitation; and movement. However, a systematic comparison evaluating the relative advantages and disadvantages of these various sensors has received little study. The purpose of the present study was to compare these sensor subtypes using treadmill testing and an outdoor test circuit, which simulated daily life activities and included both uphill and downhill walking. Pacemakers were strapped on the chest of healthy volunteers and connected to one channel of an ambulatory recording device, which also recorded the subject's intrinsic heart rate. The pacemakers were programmed using an initial treadmill test to standardize the rate responsive parameters for each device. Nine different pacemaker models were studied including 3 vibration-based (Elite. Synchrony, Metros). 4 acceleration-based (Relay, Excel, Ergos, Trilogy), 1 gravitational-based (Swing), and 1 movement-based (Sensorithm) device. All devices demonstrated a prompt rate response with casual walking on flat ground. The vibration-, gravitational-, and movement-based pacemakers showed a pronounced rate decline during more strenuous work, e.g., walking uphill. This phenomenon was absent in the accelerometer-based units. In particular, the vibration- and movement-based units showed a higher rate with walking downhill compared to uphill. An optimally tuned rote behavior on the treadmill usually did not provide an optimal rate behavior during daily activities and there was a tendency to overstimulation during low workload. The development of the two newest sensors (gravitational and movement) did not result in an improved performance of rate response behavior. Overall, the accelerometer-based pacemakers simulated or paralleled sinus rate behavior the most closely.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1540-8159.1997.tb03566.x
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  • 7
    Digitale Medien
    Digitale Medien
    Adaptive, Agile Approaches to Organizational Architecture Utilizing Agent Technology (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Decision sciences 28 (1997), S. 0 
    Details
    ISSN: 1540-5915
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Wirtschaftswissenschaften
    Notizen: Intelligent agent-based approaches to software support systems are believed to provide an unparalleled technology for integrating people, materials, and capital equipment. Software agents can be used to automate mechanization strategies for reducing the information content of work. As such, software agents diminish the need for utilizing humans to do repetitive, programmable tasks.The purpose of studies of communities of intelligent agents is to ascertain their ability to accommodate flexible, agile organizational structures that can respond rapidly to changes in the marketplace, increase throughput, reduce costs, and improve quality. This paper presents a conceptual prototype for agent-based structural selfdesign and describes experiments conducted regarding such studies together with the results obtained.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1540-5915.1997.tb01320.x
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  • 8
    Digitale Medien
    Digitale Medien
    High Thresholds May Alter End-of-Life Behavior in a Dual Chamher Pacemaker (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 20 (1997), S. 0 
    Details
    ISSN: 1540-8159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We noted a series of 12 consecutive patients with a DDD Genisis® pacemaker that showed an unexpected and a relatively rapid fall in battery voltage and output as these devices approached end-of-life (EOL). Twenty-one of 24 leads were Vitatron Helifix® leads and there was a relatively high mean threshold (atrial 2.5 ± 0.94 V: ventricular 2.9 ± 0.65 V) These devices were replaced after 65 ± 12 months. During the 9.3 ± 3.5 months before replacement, a striking fall in voltage from 2.7 ± 0.04 V to 2.49 ± 0.05 V was seen. Battery impedance rose from 3 ± 1.2 KΩ to 10.2 ± 4.3 KΩ during this same period. We unexpectedly observed a marked difference between programmed and telemetered output for both atrial (50%) and ventricular leads (30%). A discrepancy between measured and telemetered magnet rate was also seen. Despite this relatively rapid fall in battery voltage, several of these devices did not meet the manufacturer's recommended replacement time (RRT) criteria by magnet rate or according to the projected RRT determined by the relationship of battery impedance to current drain. These data have implications for the selection of RRT and EOL criteria for this device. Magnet rate measured by surface ECG was the safest indicator for RRT. Follow-up for this pulse generator should be increased to every 2 months when battery impedance is 〉 2 KOhms or if there is a difference between programmed and measured output amplitude of more than 15%. The data also highlight the effect of combining high threshold leads with modern pacemakers with relatively “small” batteries as well as certain problems with telemetered data
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1540-8159.1997.tb03541.x
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  • 9
    Digitale Medien
    Digitale Medien
    Right Ventricular Outflow Tract Pacing (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 20 (1997), S. 0 
    Details
    ISSN: 1540-8159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: “He who expresses an opinion should not voice it as correct and right but set it forth as a contribution to the consensus of opinion, for the light of reality becomes apparent when two opinions coincide. A spark is produced when flint and steel come together. Man should weigh his opinions with the utmost serenity, calmness, and composure. Before expressing his own views he should carefully consider the views already advanced by others. If he finds that a previously expressed opinion is more true and worthy, he should accept it immediately and not willfully hold to an opinion of his own. By this excellent method he endeavors to arrive at unity and truth.”—Abdu'l-Bahá1
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1540-8159.1997.tb06775.x
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  • 10
    Digitale Medien
    Digitale Medien
    Acute Hemodynamic Effects of Atrioventricular Pacing at Differing Sites in the Right Ventricle Individually and Simultaneously (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 20 (1997), S. 0 
    Details
    ISSN: 1540-8159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We hypothesized that pacing, which provided a rapid uniform contraction of the ventricles with a narrower QRS, would produce a better stroke volume and cardiac output (CO). We sought to study whether pacing simultaneously at two sites in the right ventricle (right ventricular apex and outflow tract) would provide a narrower QRS and improved CO in 11 patients undergoing elective electrophysiology studies. Patients were studied by transthoracic echocardiography measurement of CO using the Doppler flow velocity method in normal sinus rhythm, AOO pacing (rate 80), DOO pacing in the right ventricular apex (AV delay 100 ms). DOO pacing in the right ventricular outflow tract, and DOO pacing at both right ventricular sites simultaneously in random order. The COs were 5.42 ± 1.83, 5.61 ± 1.97. 5.67 ± 1.6. 5.84 ± 1.68. and 5.86 ± 1.52 L/min, respectively (no significant difference by repeated measures analysis of variance [ANOVA]). The QRS durations were 0.09 ± 0.02, 0.09 ± 0.02. 0.13 ± 0.027, 0.13 ± 0.03, and 0.11 ± 0.03 sees respectively. Repeated measures ANOVA showed that the QRS duration significantly increased with right ventricular apex or right ventricluar outflow tract pacing compared to sinus rhythm and AOO pacing (P 〈 0.001) but then diminished with pacing at both sites (P 〈 0.01). QRS duration was not correlated with CO, however the change in QRS duration correlated significantly with the change in CO when pacing was performed at the two right ventricular sites simultaneoasly. In conclusion, during DOO pacing, there was a trend for pacing in the right ventricular outflow tract or both sites to improve the CO compared to the right ventricular apex. With simultaneous pacing at both ventricular sites, the QRS narrowed. Further studies will be required to see if this approach has value in patients with poor left ventricular function or congestive heart failure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1540-8159.1997.tb05493.x
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