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  • 1
    Electronic Resource
    Electronic Resource
    Dichlorobis[4,4,5,5-tetramethyl-2-(2-pyridyl)-4,5-dihydro-1H-imidazol-1-yloxy 3-oxide]copper(II) Bis(dichloromethane) Solvate (1997)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 53 (1997), S. 0-0 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270197099538
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  • 2
    Electronic Resource
    Electronic Resource
    Isolation and characterization of the krev-1 gene, a novel member of ras superfamily in Neurospora crassa: involvement in sexual cycle progression (1997)
    Springer
    Molecular genetics and genomics 255 (1997), S. 429-437 
    Details
    ISSN: 1617-4623
    Keywords: Key wordsNeurospora crassa ; ras superfamily ; krev-1 ; Krev-1/rap1A/smg21A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Genes belonging to the ras superfamily encode low-molecular-weight GTP/GDP-binding proteins that are highly conserved in wide variety of organisms. We used the polymerase chain reaction (PCR) to isolate a novel member of the ras superfamily from the filamentous fungus Neurospora crassa and obtained a mammalian Krev-1 homolog. We named the gene krev-1 and analyzed its structure and function. The krev-1 gene encodes a polypeptide of 225 amino acids, which is nearly 60% homologous to the mammalian Krev-1 p21. The krev-1 gene product (KREV1) is functionally analogous to mammalian Krev-1 p21 and Rsr1p/Bud1p, a Krev-1 homolog from the yeast Saccharomyces cerevisiae. GAL1-driven expression of KREV1 in a wild-type yeast strain resulted in a random budding pattern, as did its mammalian counterpart Krev-1 p21. We disrupted the krev-1 gene by RIP (repeat-induced point mutation), but the krev-1 disruptants showed no abnormalities. By in vitro mutagenesis, we constructed several mutant krev-1 genes (G21V, A68T, and D128A) which mimic constitutively active mutants of Ha-ras, and the krev-1 (K25N) mutant which is analogous to a dominant-negative mutant of Ha-ras. Each mutant gene was introduced into the wild-type strain and the phenotypes were analyzed. We could not observe any difference in vegetative growth between these transformants. When each strain was used as the female in mating tests, the development of perithecia from protoperithecia was inhibited in all cases. The results indicate that the krev-1 gene may be involved in sexual cycle progression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380050515
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  • 3
    Electronic Resource
    Electronic Resource
    Genetic and molecular characterization of Neurospora crassamus-23 :a gene involved in recombinational repair (1997)
    Springer
    Molecular genetics and genomics 256 (1997), S. 436-445 
    Details
    ISSN: 1617-4623
    Keywords: Key wordsNeurospora crassa ; mus-23 ; MRE11 ; Recombinational repair ; Histidine sensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A newly isolated mutant, mus-23, of Neurosporacrassa was found to be highly sensitive to a wide variety of mutagens, including UV light, methyl methanesulfonate, 4-nitroquinoline 1-oxide, N-methyl-N′-nitro-N-nitrosoguanidine and tert-butyl hydroperoxide. This mutant was originally isolated as a mutant that could not grow on medium containing histidine. Meiosis and sporulation were defective in homozygous crosses between mus-23 haploids. The mus-23 gene is located on the right arm of LGII, between fl and trp-3. Analyses of epistasis between mus-23 and other mutations that cause defects in DNA repair indicated that the mus-23 gene belongs to the same DNA repair group as mei-3, which is the Neurospora homolog of the Saccharomyces cerevisiae gene RAD51. The double mutant carrying mus-23 and uvs-3 mutations was lethal. The mus-23 gene was cloned by complementation of the MMS-sensitive phenotype of the mus-23 mutant. The gene contained an open reading frame of 1578 bp and did not contain any introns. The molecular weight of the predicted mus-23 gene product was 60.4 kDa. Computer analyses revealed that the MUS23 protein has significant homology to Mre11p, which is known to be involved in recombinational repair in S. cerevisiae. The level of mus-23 transcripts increased significantly within 60 min of treatment with UV or MMS and then gradually decreased. The role of MUS23 protein in recombinational repair is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380050587
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  • 4
    Electronic Resource
    Electronic Resource
    Basal interhemispheric supra- and/or infrachiasmal approaches via superomedial orbitotomy for hypothalamic lesions: preservation of hypothalamo-pituitary functions in combination treatment with radiosurgery (1997)
    Springer
    Child's nervous system 13 (1997), S. 250-256 
    Details
    ISSN: 1433-0350
    Keywords: Key words Operative approach ; Orbitotomy ; Hypothalamus ; Craniopharyngioma ; Pituitary adenoma ; Radiosurgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although several approaches to the hypothalamus have been used, none is able to give full views of the hypothalamus. The risk of permanent morbidity for hypothalamo-pituitary functions is still high, especially in patients with cranio-pharyngioma. Basal interhemispheric supra-chiasmal or infra-chiasmal approaches via superomedial orbitotomy were developed for better visualization of the hypothalamus. Operative techniques and results, including combination treatment with radiosurgery, are reported. Twelve patients with tumors compressing the hypothalamus upward or extending into the III ventricle, or both, were operated on: 3 tumors were removed totally, 6 tumors subtotally and 3 tumors partially. Six patients received radiosurgery for residual tumor. Four patients with hypopituitarism preoperatively required oral corticosteroids and thyroid hormones postoperatively. The basal interhemispheric approach via superomedial orbitotomy is useful for better visualization of the hypothalamus and preservation of hypothalamo-pituitary functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050078
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  • 5
    Electronic Resource
    Electronic Resource
    Magnetic resonance chemical shift imaging in bone and soft tissue tumours (1997)
    Springer
    International orthopaedics 21 (1997), S. 9-13 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Ce travail étudie la localisation tumorale et le diagnostic des tumeurs de l’os et des parties molles par la technique de Dixon (technique 3 PD) qui sépare, en résonance magnétique, les signaux d’origine graisseuse ou hydrique. Nous comparons les résultats obtenus par cette technique avec résonance magnétique conventionnelle et utilisation de Gadolinium qui réhausse les images pondérées en T1. Cette étude a été faite dans 14 cas de tumeur de l’os et des parties molles avec un appareil à 0.5 Tesla. La localisation des tumeurs était améliorée par la méthode de Dixon comparée à la résonance magnétique conventionnelle. La différenciation entre les composants hydriques ou graisseux fut aussi possible. Des images obtenues avec Gadolinium étaient très sensibles pour le réhaussement des tissus. La technique 3 PD est utile quand la détection de la zone tumorale est difficile et quand des informations sur les composants tumoraux sont nécessaires. De plus, ces images peuvent être obtenues avec un champ magnétique de faible intensité.
    Notes: Summary. A study was carried out in 14 patients to assess the location and differential diagnosis of bone and soft tissue tumours with a 0.5 Tesla scanner, using water and fat images obtained by the three-point Dixon technique. We compared the magnetic resonance imaging findings obtained with this technique with conventional MRI, T1- T2-weighted images, and gadalinium-diethylenetriamine penta-acetic acid enhanced T1-weighted images. Localisation was better with the three-point Dixon technique than with conventional magnetic resonance imaging. Differentiation between the fat and water component around the tumour was possible. The gadalinium-diethylenetriamine penta-acetic acid enhanced water images were very sensitive to enhancement of the tissue. The three-point Dixon technique is useful when the tumour area is difficult to detect by conventional magnetic resonance imaging and information about its components is needed; these images can be made at the low magnet field.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002640050109
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  • 6
    Electronic Resource
    Electronic Resource
    Preparation of hexa-aluminate catalyst thick films on α-SiC substrate for high temperature application (1997)
    Springer
    Journal of materials science 32 (1997), S. 4627-4632 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The coating of Mn-substituted hexa-aluminate catalysts (BaMnAl11O19-α and Sr0.8La0.2MnAl11O19-α) on α-SiC substrates was investigated for high temperature application above 1000°C. The thermal stability of the hexa-aluminate catalyst films on the α-SiC substrates was significantly affected by reactivity between the oxidized layer (SiO2) of the surfaces of the substrates and the coated layers. The Mn-substituted hexa-aluminate films were thermally less stable due to their high reactivity than unsubstituted hexa-aluminates. The Sr0.8La0.2MnAl11O19-α film directly coated on the substrate exfoliated from the substrate even after heating at 1200°C due to its high reactivity to the SiO2 layer, whereas the BaMnAl11O19-α film was stable after the same treatment. The thermal stability of the Mn-substituted hexa-aluminate film could be improved by insertion of an Al6Si2O13 intermediate layer between the film and the SiC substrate. Additional coating of a highly crystallized Ba0.75Al11.0O17.25 intermediate layer underneath the BaMnAl11O19-α catalyst layer was also effective. The Al6Si2O13 and Ba0.75Al11.0O17.25 intermediate layers suppressed the diffusion of SiO2 from the substrate and subsequent reaction between SiO2 and the hexa-aluminate film.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018693822575
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  • 7
    Electronic Resource
    Electronic Resource
    Cathodic polarization of copper electrode in CuCN–KCN solutions and the current distribution for copper deposition on grooved substrates (1997)
    Springer
    Journal of applied electrochemistry 27 (1997), S. 529-538 
    Details
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The cathodic polarization of a copper electrode in CuCN/KCN solution was interpreted by considering the diffusion and migration of all ionic species, chemical reactions involving cyano-copper(i) complexes, and the quasiequilibrium of charge transfer reaction. Experimental polarization curves were compared with theoretical ones, where the diffusion layer thickness was determined. The present model was applied to the prediction of thickness distribution of copper coating on grooved substrates. Two types of substrates with grooves of different size (width × depth), (a) 5mm × 5mm and (b) 1mm × 1mm, were used. Agreement between theory and experiment was satisfactory for substrate a, but not for substrate b. The effect of convective mass transfer in the groove was discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018490410509
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