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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 157 (1998), S. 445-450 
    ISSN: 1432-1076
    Keywords: Key words Folic acid ; Neural tube defects ; Birth defects ; 5 ; 10 Methylenetetrahydrofolate reductase ; Primary prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Paediatricians need to be aware of the broad implications that sufficient maternal folic acid intake has on the wellbeing of the embryo and fetus. There is now strong evidence that adequate periconceptional maternal folic acid supplementation during critical periods of organ formation is associated with reduction in both the occurrence and recurrence of neural tube defects, congenital heart defects (particularly conotruncal heart defects), obstructive urinary tract anomalies, limb deficiencies, orofacial clefts and congenital hypertrophic pyloric stenosis. Inadequate maternal folic acid intake is associated with preterm deliveries, intra-uterine growth retardation, placental abruption and infarction, while maternal folic acid supplementation is associated with a reduction in preterm deliveries and intra-uterine growth retardation. Recently adequate folic acid intake in adults has been associated with a reduction in adult cardiovascular disease and some cancers. A common mutation in the 5,10 methylenetetrahydrofolate reductase gene has been identified which produces a thermolabile variant of 5,10 methylenetetrahydrofolate reductase with reduced enzyme activity. The common mutation is a risk factor both for neural tube defects and adult cardiovascular diseases. Folic acid acts to increase the activity of the variant methylenetetrahydrofolate reductase thereby reducing plasma homocysteine levels. However the polymorphism does not explain all of the protective effects of folic acid. Conclusion Primary prevention of birth defects by adequate periconceptional folic acid supplementation is a major public health opportunity and has wide implications in reducing both mortality and morbidity due to birth defects and several adult diseases. It follows that there would also be a curbing of health care costs related to those disorders.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Global change biology 4 (1998), S. 0 
    ISSN: 1365-2486
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: The effect of CO2 concentration on plant growth and the size of the rhizosphere denitrifier population was investigated for ryegrass grown at 3 different soil pH values (pH 4.3, 5.9 and 7.0). Soil microcosms were planted with ryegrass and maintained under constant growth conditions at either ambient (450ppm) or elevated (720ppm) CO2 concentration. At harvest, the rhizosphere soil was collected and subjected to a potential denitrification assay to provide an estimate of the size of the denitrifier population present. Ryegrass dry matter production varied across the pH range studied and contrary to other studies, elevated CO2 concentration did not consistently increase growth. Plant growth was reduced by ≈ 35% and 23% at pH 4.3 and pH 5.9, respectively, under elevated CO2 concentration. At pH 7.0, however, plant growth was increased by ≈ 45% under elevated CO2. Potential denitrification rates within the rhizosphere followed a similar pattern to plant growth in the different treatments, suggesting that plant growth and the size of denitrifier population within the rhizosphere are coupled. This study investigates the relationship between plant growth and rhizosphere denitrification potential, thereby providing an estimate of the size of the denitrifier population under increased CO2 concentration and soil pH.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford : Blackwell Science Ltd
    Anaesthesia 53 (1998), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Annals of operations research 81 (1998), S. 27-50 
    ISSN: 1572-9338
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Notes: Abstract This paper describes ASYNPLEX, an asynchronous variant of the revised simplex methodwhich is suitable for parallel implementation on a shared memory multiprocessor or MIMDcomputer with fast inter-processor communication. The method overlaps simplex iterationson different processors. Candidates to enter the basis are tentatively selected using reducedcosts which may be out of date. Later, the up-to-date reduced costs of the tentative candidatesare calculated and candidates are either discarded or accepted to enter the basis. The implementationof this algorithm on a Cray T3D is described and results demonstrating significantspeed-up are presented.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 77 (1998), S. 278-284 
    ISSN: 1439-6327
    Keywords: Key words Head-out water immersion Walking exercise ; Oxygen consumption Effects of temperature ; Stride frequency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study compared the cardiorespiratory responses of eight healthy women (mean age 30.25 years) to submaximal exercise on land (LTm) and water treadmills (WTm) in chest-deep water (Aquaciser). In addition, the effects of two different water temperatures were examined (28 and 36°C). Each exercise test consisted of three consecutive 5-min bouts at 3.5, 4.5 and 5.5 km · h−1. Oxygen consumption (V˙O2) and heart rate (HR), measured using open-circuit spirometry and telemetry, respectively, increased linearly with increasing speed both in water and on land. At 3.5 km · h−1 V˙O2 was similar across procedures [χ = 0.6 (0.05) l · min−1]. At 4.5 and 5.5 km · h−1 V˙O2 was significantly higher in water than on land, but there was no temperature effect (WTm: 0.9 and 1.4, respectively; LTm: 0.8 and 0.9 l · min−1, respectively). HR was significantly higher in WTm at 36°C compared to WTm at 28°C at all speeds, and compared to LTm at 4.5 and 5.5 km · h−1 (P ≤ 0.003). The HR-V˙O2 relationship showed that at a V˙O2 of 0.9 l · min−1, HR was higher in water at 36°C (115 beats · min−1) than either on land (100 beats · min−1) or in water at 28°C (99 beats · min−1). The Borg scale of perceived exertion showed that walking in water at 4.5 and 5.5 km · h−1 was significantly harder than on land (WTm: 11.4 and 14, respectively; LTm: 9.9 and 11, respectively; P ≤ 0.001). These cardiorespiratory changes occurred despite a slower cadence in water (the mean difference at all speeds was 27 steps/min). Thus, walking in chest-deep water yields higher energy costs than walking at similar speeds on land. This data has implications for therapists working in hydrotherapy pools.
    Type of Medium: Electronic Resource
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