Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Steigende Frequenz bariatrisch-chirurgischer Eingriffe seit Ersatz der Gastroplastik durch das laparoskopische Magenband zur Behandlung der morbiden Adipositas (1999)
    Springer
    Der Chirurg 70 (1999), S. 190-195 
    Details
    ISSN: 1433-0385
    Keywords: Key words: Morbid obesity ; Gastroplasty ; Laparoscopic gastric banding ; Morbidity ; Mortality. ; Schlüsselwörter: Morbide Adipositas ; Gastroplastik ; laparoskopische Magenbandoperation ; Morbidität ; Letalität.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Zwischen 1984 und 1996 wurde an unserer Klinik bei der Behandlung der morbiden Adipositas die Gastroplastik nach Mason an 14 Patienten im Alter von 40 (26–48) Jahren, Body-mass-Index (BMI) 48 (37–71) kg/m2, Übergewicht 67 (41–116) kg durchgeführt. Seit Dezember 1996 wenden wir das justierbare laparoskopische „gastric banding“ (Lap-band) an: 73 Patienten im Alter von 39 (22–64) Jahren, BMI 45 (32–69) kg/m2, Übergewicht 66 (30–169) kg. Wir untersuchten Früh- und Spätresultate beider Methoden. Frühresultat: Bei beiden Methoden beobachteten wir keine relevante Morbidität und keine Letalität. Spät/Intermediärresultat: Reoperationsrate 15 % bei beiden Methoden. Nach Gastroplastik war die Abnahme des Übergewichts nach durchschnittlich 3,7 Jahren 54 (22–96) %, nach Lap-band bei 24 Patienten nach 12 Monaten 47 (11–127) % und bei 8 Patienten nach 18 Monaten 51 (28–139) %. Seit Einführung der laparoskopischen Technik hat die Anzahl bariatrisch-chirurgischer Eingriffe stark zugenommen. Dennoch blieben die Komplikationsrate gering und das Spätresultat vergleichbar.
    Notes: Summary. Between 1984 and 1996 we performed a Mason gastroplasty for the treatment of morbid obesity: 14 patients (average age 40 (26–48) years, body mass index (BMI) 48 (37–71) kg/m2, excessive body weight 67 (41–116) kg). Since the end of 1996 we now apply adjustable laparoscopic gastric banding (lab band): 73 patients (average age 39 (22–64) years, BMI 45 (32–69) kg/m2, excessive body weight 66 (41–116) kg). We compared the early and late results of both methods. Early results: no relevant morbidity or mortality for neither method. Late/intermediate results: reoperation rate for both methods 15 %. After an average of 3.7 years the excessive body weight loss (EWL) for gastroplasty was 54 (22–96) %. The EWL after lab band for 24 patients after 12 months was 47 (11–127) % and for 8 patients after 18 months 51 (28–139) %. Since the introduction of the lap band the number of bariatric operations has greatly increased. Nevertheless, the perioperative complication rate has remained low, and the long-term outcome is similar for both methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00002592
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effect of HMG-CoA reductase inhibitors on extracellular matrix expression in human vascular smooth muscle cells (1999)
    Springer
    Basic research in cardiology 94 (1999), S. 322-332 
    Details
    ISSN: 1435-1803
    Keywords: Key words Atherosclerosis – extracellular matrix – HMG-CoA reductase inhibitors – smooth muscle – thrombospondin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clinical studies have shown that treatment with 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors can stabilize atherosclerotic plaques and slow their progression. One determinant of plaque stability and size is the composition of the vascular extracellular matrix. The aim of this study was to evaluate the effects of different HMG-CoA reductase inhibitors on the expression of major components of the vascular extracellular matrix in smooth muscle cells. Cultured human vascular smooth muscle cells were incubated for 24–72 h with the HMG-CoA reductase inhibitors lovastatin (1–50 μmol/L), simvastatin (0.05–20 μmol/L), and pravastatin ( 1–100 μmol/L). RNA expression of the extracellular matrix proteins thrombospondin-1, fibronectin, collagen type I, and biglycan as well as expression of the cytokine TGF-β1 was determined by Northern blotting. Extracellular matrix protein secretion was visualized by immunofluorescence. In addition, cell proliferation and viability were measured using BrDU-ELISAs, MTT-tests, and direct cell counting. Expression of thrombospondin-1 was significantly decreased after 24 h incubations with lovastatin in concentrations as low as 1 μmol/L. Coincubation with the cholesterol precursor mevalonate completely reversed this effect. The downregulation of thrombospondin-1 expression occured in the same concentration range that also inhibited cell proliferation. In contrast, lovatatin did not affect expression of fibronectin, whereas collagen type I and biglycan expression decreased only after long incubations with high, toxic lovastatin concentrations. Simvastatin, but not the very hydrophilic compound pravastatin, had a similar effect on extracellular matrix expression as lovastatin. In summary, lovastatin and simvastatin predominantly decrease the expression of the glycoprotein thrombospondin-1, which is functionally associated with smooth muscle cell migration and proliferation. In contrast, expression of plaque-stabilizing extracellular proteins such as collagen type I and biglycan are much less affected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003950050158
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...