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  • 1
    Electronic Resource
    Electronic Resource
    Protection by a cyclic AMP-specific phosphodiesterase inhibitor, rolipram, and dibutyryl cyclic AMP against Propionibacterium acnes and lipopolysaccharide-induced mouse hepatitis (1999)
    Springer
    Inflammation research 48 (1999), S. 380-385 
    Details
    ISSN: 1420-908X
    Keywords: Key words:P. acnes/LPS hepatitis model — Macrophages/ Kupffer cells — Tumor necrosis factor-α— Phosphodiesterase — Rolipram
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: To study the effect of cellular cAMP-increasing agents on Propionibacterium acnes (P. acnes) and lipopolysaccharide (LPS)-induced mouse hepatitis.¶Material: Male BALB/c mice were used. Macrophages/Kupffer cells isolated from P. acnes-primed murine liver were used for the in vitro study.¶Treatment: Type IV phosphodiesterase (PDE)-specific inhibitor, rolipram, was administered (10, 30 mg/kg, p.o.). Dibutyryl cyclic AMP (dbcAMP) was injected (10, 100 mg/kg, i.p.) into the mice.¶Method: Plasma TNFα estimated by the use of an L-929 cell cytotoxic assay and plasma transaminase activities were measured for the in vivo study. The LPS-induced production of TNFα in vitro from the cultured macrophage/Kupffer cells was determined by ELISA.¶Results: Rolipram suppressed the elevation of plasma transaminases induced by injection of LPS, and dbcAMP had a tendency to suppress them. Both agents attenuated the LPS-induced release of TNFα in vivo, and suppressed the TNFα production from the cultured macrophage/Kupffer cells.¶Conclusions: These results suggest that rolipram and dbcAMP have potential to inhibit TNFa production from activated macrophage/Kupffer cells, and it may be partially involved in the protecting effect in the P. acnes/LPS hepatitis model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050475
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  • 2
    Electronic Resource
    Electronic Resource
    RNA editing sites in tobacco chloroplast transcripts: editing as a possible regulator of chloroplast RNA polymerase activity (1999)
    Springer
    Molecular genetics and genomics 262 (1999), S. 462-467 
    Details
    ISSN: 1617-4623
    Keywords: Key words Chloroplast ; Tobacco ; Post-transcriptional regulation ; RNA editing ; RNA polymerase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Genetic information in chloroplast DNA is sometimes altered at the transcript level by a process known as RNA editing. Sequence analysis of amplified cDNAs for 69 potential editing sites revealed 13 real editing sites in transcripts of 11 tobacco chloroplast genes. Together with those reported previously, these bring the total of edited sites observed in tobacco chloroplast transcripts to 31 (all involve C to U conversion). Alignment of sequences around the 31 editing sites revealed no obvious consensus, apart from an apparent bias for U or C at position −1 and A at position +2. Editing in tobacco rpoA mRNA restores the conserved leucine residue which is known to be important for transcriptional activation of the α subunit of E. coli RNA polymerase. Editing of this site is partial and the extent of editing depends on developmental conditions, suggesting that editing is, at least in part, involved in the regulation of chloroplast-encoded RNA polymerase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380051106
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Energy-scale dependence of the lepton flavor-mixing matrix (1999)
    Springer
    The European physical journal 10 (1999), S. 677-680 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. We study an energy-scale dependence of the lepton flavor-mixing matrix in the minimal supersymmetric standard model with the effective dimension-five operators, which give Majorana masses of neutrinos. We analyze the renormalization group equations of the coefficients ( $\kappa_{ij}$ ) of these effective operators under an approximation that neglects terms of order $\kappa^2$ . We find that only $n_\mathrm{g}-1$ (where $n_\mathrm{g}$ is the generation number) real independent parameters in the lepton flavor-mixing matrix depend on the energy scale. In particular, all the phases in $\kappa$ are scale-independent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100529900152
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    Paper (German National Licenses)
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