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Digitale Medien

Studies on the binding mechanism of fluoroquinolones to melanin (2000)

Fukuda, M. ; Morita, Y. ; Sasaki, K. ; [weitere]

Springer

Journal of infection and chemotherapy 6 (2000), S. 72-76

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Details

ISSN: 1437-7780

Schlagwort(e): Key words Ocular melanin ; Melanin affinity ; Fluoroquinolones ; Metal ions ; Binding mechanism

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract In order to elucidate the binding mechanism of melanin and fluoroquinolones (ofloxacin, norfloxacin, ciprofloxacin, lomefloxacin, levofloxacin), we investigated the interaction of fluoroquinolones with compounds such as l-β-(3,4-dihydroxyphenyl) alanine (l-DOPA), l-tyrosine, 5-hydroxy-l-tryptophan, l-tryptophan, and l-phenylalanine, which possess the kind of functional groups that melanin does and are closely related to melanin. The recovery of drugs from the melanin-drug complexes by metal ions of Li, Na, Ka, Mg, Ca, Ba, Cu, Ni, and Fe was demonstrated. Smaller and highly charged cations were found to be more effective for this recovery, and magnesium ions were the most effective of all the ions investigated.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/PL00012154

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