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  • Electronic Resource  (37)
  • 2005-2009  (37)
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  • Electronic Resource  (37)
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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of obstetric, gynecologic and neonatal nursing 34 (2005), S. 0 
    ISSN: 1552-6909
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective: To examine the effect of kangaroo care on heart rate variability in a healthy preterm infant. Design: Case study. Setting: Private room on a postpartum unit. Participant: A mother–preterm infant dyad. Intervention: Kangaroo (skin-to-skin) care. Main Outcome Measure: Heart rate variability, a noninvasive measurement of the sympathetic and parasympathetic components of the autonomic nervous system's influence on heart rate. Results: Heart rate variability, especially the parasympathetic component, was high when the infant was fussy in the open crib, indicating increased autonomic nervous system activity. With kangaroo care, the infant fell asleep, and both sympathetic and parasympathetic components of heart rate variability decreased. Conclusions: The wide fluctuations in the parasympathetic component of heart rate variability suggest immaturity of the sympathovagal response. Overall, kangaroo care produced changes in heart rate variability that illustrate decreasing stress.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Berkeley, Calif. : Berkeley Electronic Press (now: De Gruyter)
    Global economy journal 5 (2005), S. 1 
    ISSN: 1524-5861
    Source: Berkeley Electronic Press Academic Journals
    Topics: Economics
    Notes: Large current account deficits and foreign debt levels remain a source of concern for international financial markets and policymakers. Yet, exactly what an "excessive" external deficit or liability position for an advanced economy is at any time has never been adequately defined. This article addresses the question by proposing new methods for assessing the proximity of current account deficits and the associated foreign debt to their upper bounds. It contends that productive investment fundamentally sets the feasible limit for current account deficits, whereas the capital to output ratio ultimately sets the foreign debt to GDP limit. Benchmark estimates for the United States, Australia, New Zealand and the United Kingdom, advanced economies that have borrowed heavily since 1990, reveal external deficits have usually been well within limits, although recent United States experience is an exception.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Campylobacter jejuni is a Gram-negative food-borne pathogen associated with gastroenteritis in humans as well as cases of the autoimmune disease Guillain–Barré syndrome. C. jejuni is asaccharolytic because it lacks an active glycolytic pathway for the use of sugars as a carbon source. This suggests an increased reliance on amino acids as nutrients and indeed the genome sequence of this organism indicates the presence of a number of amino acid uptake systems. Cj0982, also known as CjaA, is a putative extracytoplasmic solute receptor for one such uptake system as well as a major surface antigen and vaccine candidate. The crystal structure of Cj0982 reveals a two-domain protein with density in the enclosed cavity between the domains that clearly defines the presence of a bound cysteine ligand. Fluorescence titration experiments were used to demonstrate that Cj0982 binds cysteine tightly and specifically with a Kd of ∼10−7 M consistent with a role as a receptor for a high-affinity transporter. These data imply that Cj0982 is the binding protein component of an ABC-type cysteine transporter system and that cysteine uptake is important in the physiology of C. jejuni.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Berkeley, Calif. : Berkeley Electronic Press (now: De Gruyter)
    International journal of chemical reactor engineering 3.2005, 1, A39 
    ISSN: 1542-6580
    Source: Berkeley Electronic Press Academic Journals
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: A common form of chemical reactor is the bubbling fluidised bed where gas is introduced into a free bed of particles at a rate exceeding that necessary to support their weight. The behaviour of the reactor is dependent on the distribution and characteristics of the bubbles within the bed. Information about these can be inferred from pressure measurements within the bed, which can also be used to characterise the dynamics of a bed and therefore to control it and the reaction. It is necessary to understand what the pressure signals are measuring, how many of them are necessary, and where they should be placed for them to be used to characterise the state of the bed. Pressure measurements are made at single points within a bed, and it is not immediately clear whether the measurements are local (owing to some sort of wall effect, for example), characterise the region close to the sensor, or the whole bed. It is shown how the dynamics of the bed can be characterised from the pressure signals, and that these signals are sensitive to the state of the bed. It is also necessary to evaluate where the sensors should be placed and how many of them should be used. Important considerations here are the extent to which the measurements of pressure are axisymmetrical, and whether in some circumstances and positions the local dynamics mask the overall bed dynamics. Axisymmetry is shown to exist under many conditions and that a single transducer can be sufficient. Furthermore, the depth of the bed is also shown to have a significant effect on its dynamics. It is also shown how the characterised pressure measurements can be used to control the state of the fluidised bed and used to enhance the performance of a fluidised bed reactor.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 74 (2005), S. 433-480 
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Notes: This review focuses on nontemplate-dependent polymerases that use water-soluble substrates and convert them into water-insoluble polymers that form granules or inclusions within the cell. The initial part of the review summarizes briefly the current knowledge of polymer formation catalyzed by starch and glycogen synthases, polyphosphate kinase (a polymerase), cyanophycin synthetases, and rubber synthases. Specifically, our current understanding of their mechanisms of initiation, elongation (including granule formation), termination, remodeling, and polymer reutilization will be presented. General underlying principles that govern these types of polymerization reactions will be enumerated as a paradigm for all nontemplate-dependent polymerizations. The bulk of the review then focuses on polyhydroxyalkanoate (PHA) synthases that generate polyoxoesters. These enzymes are of interest as they generate biodegradable polymers. Our current knowledge of PHA production and utilization in vitro and in vivo as well as the contribution of many proteins to these processes will be reviewed.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 57 (2006), S. 195-206 
    ISSN: 0066-4219
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Notes: We review the diagnosis, categorization, and treatment of prostatitis/chronic pelvic pain syndrome based on the National Institutes of Health (NIH) classification. Prostatitis is an extremely common syndrome that afflicts 2%Đ??10% of men. Formerly a purely clinical diagnosis, prostatitis is now classified within a complex series of syndromes (NIH category IĐ??IV prostatitis) that vary widely in clinical presentation and response to treatment. Acute bacterial prostatitis (category I) and chronic bacterial prostatitis (category II) are characterized by uropathogenic infections of the prostate gland that respond well to antimicrobial treatment. In contrast, chronic prostatitis/chronic pelvic pain syndrome (category III), which accounts for 90%Đ??95% of prostatitis cases, is of unknown etiology and is marked by a mixture of pain, urinary, and ejaculatory symptoms with no uniformly effective therapy. Asymptomatic inflammatory prostatitis (category IV) is an incidental finding of unknown clinical significance. This review describes the current status of prostatitis syndromes and explores the future prospects of new diagnostic tools and therapies.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing
    Psychophysiology 42 (2005), S. 0 
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Startle eyeblink modification was measured during a continuous performance test (CPT) with either clearly focused stimuli or visually degraded stimuli to measure the effects of early perceptual processing demands on startle modification. A startling noise was presented either 120, 240, or 1200 ms following target and nontarget CPT stimuli. In the degraded stimulus CPT, startle inhibition at 240 ms was greater following targets than nontargets and was as great during targets at 240 ms as at 120 ms, whereas in the clearly focused CPT, inhibition declined significantly from 120 to 240 ms. The results indicate that maximum prepulse inhibition is extended in time when the task involves discrimination of degraded visual stimuli and when early perceptual processing demands are high. At 1200 ms, targets and nontargets produced nondifferential inhibition during both CPTs, suggesting that modality-specific attention occurred equally for the two tasks.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Carbon dioxide has been rapidly accumulating in the atmosphere and is expected to continue to do so. This accumulation is presumed to have important direct effects on plant growth. The interacting affects of a small increase in CO2 concentration (466 p.p.m., approximately 30% increase from current ambient conditions), nitrogen fertilization and fungal endophyte (Neotyphodium lolii) infection on the growth and chemical composition of perennial ryegrass (Lolium perenne) were investigated. It was found that dry mass production was approximately 50% greater under elevated CO2 than under ambient CO2, but only in conditions of high soil N. High molecular weight carbohydrates and total carbohydrates (LMW + HMW CHO) depended on an interaction between CO2 and endophyte infection. Infected plants contained significantly more carbohydrate than endophyte-free plants, and the difference was greatest in ambient CO2 conditions. Protein concentrations were also influenced by the interaction between CO2 and endophyte-infection. Endophyte-free plants had 40% lower concentrations of soluble protein under elevated CO2 than under ambient CO2, but this CO2 effect on soluble protein was largely absent in endophyte-infected plants. CO2, endophyte-infection and nitrogen interacted to influence the total chlorophyll concentration of the grass such that chlorophyll concentration was always lower in elevated CO2 but this decline was much greater in endophyte-free plants, particularly in conditions of high soil N. In the endophyte-infected plants, the concentrations of the pyrrolopyrazine alkaloid peramine depended on the interaction between CO2 and N fertilization such that peramine concentrations declined with increasing N at ambient CO2 but remained roughly constant across N levels at elevated CO2. A similar pattern was seen for the ergot alkaloid ergovaline. The biochemical responses of perennial ryegrass to elevated CO2 are clearly modified by the presence of endophytic fungi.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Pty
    Clinical and experimental pharmacology and physiology 32 (2005), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Huntington's disease (HD) is a fatal autosomal dominant disorder in which there is progressive neurodegeneration producing motor, cognitive and psychiatric symptoms. The dynamic mutation that causes the disease is common to numerous other brain disorders, which may share similar pathogenic mechanisms.2. Much progress has been made in the past decade in understanding how a trinucleotide (CAG) repeat expansion, encoding an expanded polyglutamine tract in the huntingtin protein, induces dysfunction at molecular and cellular levels. The present review integrates various lines of experimental evidence in an attempt to move towards a unifying mechanistic framework, which may explain the pathogenesis of HD, from molecular through to neuronal network and behavioural levels.3. Recent evidence, using transgenic mouse models, also suggests that environmental factors can modify the onset and progression of HD. The effects of specific environmental manipulations are discussed in the context of gene–environment interactions and experience-dependent plasticity in the healthy and diseased brain, particularly the cerebral cortex.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG trinucleotide repeat encoding an extended polyglutamine tract in the huntingtin protein. Affected individuals display progressive motor, cognitive and psychiatric symptoms (including depression), leading to terminal decline. Given that transgenic HD mice have decreased hippocampal cell proliferation and that a deficit in neurogenesis has been postulated as an underlying cause of depression, we hypothesized that decreased hippocampal neurogenesis contributes to depressive symptoms and cognitive decline in HD. Fluoxetine, a serotonin-reuptake inhibitor commonly prescribed for the treatment of depression, is known to increase neurogenesis in the dentate gyrus of wild-type mouse hippocampus. Here we show that hippocampal-dependent cognitive and depressive-like behavioural symptoms occur in HD mice, and that the administration of fluoxetine produces a marked improvement in these deficits. Furthermore, fluoxetine was found to rescue deficits of neurogenesis and volume loss in the dentate gyrus of HD mice.
    Type of Medium: Electronic Resource
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