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  • Electronic Resource  (22)
  • 2005-2009  (22)
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  • Electronic Resource  (22)
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  • 1
    Electronic Resource
    Electronic Resource
    EXPERIMENTAL FLUID MECHANICS OF PULSATILE ARTIFICIAL BLOOD PUMPS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Fluid Mechanics 38 (2006), S. 65-86 
    Details
    ISSN: 0066-4189
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The fluid mechanics of artificial blood pumps has been studied since the early 1970s in an attempt to understand and mitigate hemolysis and thrombus formation by the device. Pulsatile pumps are characterized by inlet jets that set up a rotational "washing" pattern during filling. Strong regurgitant jets through the closed artificial heart valves have Reynolds stresses on the order of 10,000 dynes/cm2 and are the most likely cause of red blood cell damage and platelet activation. Although the flow in the pump chamber appears benign, low wall shear stresses throughout the pump cycle can lead to thrombus formation at the wall of the smaller pumps (10Đ??50 cc). The local fluid mechanics is critical. There is a need to rapidly measure or calculate the wall shear stress throughout the device so that the results may be easily incorporated into the design process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.fluid.38.050304.092022
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  • 2
    Electronic Resource
    Electronic Resource
    Discontinuation of pegylated interferon plus ribavirin in patients who are not responding to therapy – patients’ views of early cessation of therapy (2005)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Current therapy for chronic hepatitis C infection involves a course of pegylated interferon and ribavirin. Patients who do not show a virological response after 12 weeks of therapy have a low probability of sustained virological response and it is therefore recommended that such patients stop treatment.Aim : To assess patients’ views of early treatment cessation.Methods : We conducted a open-labelled study in three UK centres, in which patients with biopsy-proven chronic hepatitis C requiring therapy were offered the choice of a full course of therapy with 40 kDa pegylated interferon-α 2a plus ribavirin (24 or 48 weeks depending on viral genotype) or early cessation if therapy had failed after 12 weeks.Results : Ninety-five participants were enrolled and the majority (69%) did not wish to discontinue therapy even if it had low probability of success. In this unselected UK population, very few patients (4%) did not achieve an early virological response with the 40-kDa pegylated interferon-α 2a plus ribavirin and two of the four early virological non-responders decided to continue therapy.Conclusion : Early discontinuation of ‘ineffective’ anti-viral therapy may prove less popular with patients than with health care providers, and further patient-directed education regarding the cost-effectiveness of therapy will be needed if early discontinuation of unsuccessful therapy is to be accepted by patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2004.02295.x
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  • 3
    Electronic Resource
    Electronic Resource
    A role for topoisomerase III in a recombination pathway alternative to RuvABC (2005)
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 58 (2005), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The physiological role of topoisomerase III is unclear for any organism. We show here that the removal of topoisomerase III in temperature sensitive topoisomerase IV mutants in Escherichia coli results in inviability at the permissive temperature. The removal of topoisomerase III has no effect on the accumulation of catenated intermediates of DNA replication, even when topoisomerase IV activity is removed. Either recQ or recA null mutations, but not helD null or lexA3, partially rescued the synthetic lethality of the double topoisomerase III/IV mutant, indicating a role for topoisomerase III in recombination. We find a bias against deleting the gene encoding topoisomerase III in ruvC53 or ΔruvABC backgrounds compared with the isogenic wild-type strains. The topoisomerase III RuvC double mutants that can be constructed are five- to 10-fold more sensitive to UV irradiation and mitomycin C treatment and are twofold less efficient in transduction efficiency than ruvC53 mutants. The overexpression of ruvABC allows the construction of the topoisomerase III/IV double mutant. These data are consistent with a role for topoisomerase III in disentangling recombination intermediates as an alternative to RuvABC to maintain the stability of the genome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.2005.04812.x
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  • 4
    Electronic Resource
    Electronic Resource
    Unusual Experiences, Reality Testing and Delusions of Alien Control (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Mind & language 20 (2005), S. 0 
    Details
    ISSN: 1468-0017
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Linguistics and Literary Studies , Psychology
    Notes: Abstract:  Some monothematic types of delusions may arise because subjects have unusual experiences. The role of this experiential component in the pathogenesis of delusion is still not understood. Focussing on delusions of alien control, we outline a model for reality testing competence on unusual experiences. We propose that nascent delusions arise when there are local failures of reality testing performance, and that monothematic delusions arise as normal responses to these. In the course of this we address questions concerning the tenacity with which delusions are maintained, their often bizarre content, the patients’ inability to dismiss them, and their often circumscribed character.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0268-1064.2005.00280.x
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  • 5
    Electronic Resource
    Electronic Resource
    Andrea, Sterk: Renouncing the World Yet Leading the Church: The Monk-Bishop in Late Antiquity : Cambridge, Mass., Harvard University Press, 2004 (2006)
    New York : Cambridge University Press
    Church history 75 (2006), S. 174-176 
    Details
    ISSN: 0009-6407
    Source: Cambridge Journals Digital Archives
    Topics: History , Theology and Religious Studies
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1017/S0009640700088454
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  • 6
    Electronic Resource
    Electronic Resource
    116
Applicaton of a Novel Crosslinked Glycosaminoglycan Hydrogel Scaffold Improves Healing in a Rabbit Ear Ulcer Model (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Introduction:  Hyaluronic acid (HA) is a major glycosaminoglycan component of normal dermis and a major component of the matrix synthesized during wound healing. Previous studies have shown that uncrosslinked HA is rapidly degraded and cleared in vivo, limiting its clinical utility. We have used a novel HA hydrogel scaffold that is crosslinked for prolonged bioavailability. It has a porous interior and a smooth surface. This scaffold can also be fabricated with collagen and linked to proteins or DNA to direct cell growth and differentiation. We hypothesized that this novel HA formulation might itself improve wound healing by enhancing cell migration.Purpose:  The present study explored the effects of a crosslinked HA hydrogel on wound healing.Methods:  Using an established model of wound healing, four 7 mm punch wounds were made on each ear of New Zealand rabbits. Each wound was immediately treated with topical application of one of the following: HA hydrogel (n = 26), HA/collagen hydrogel (n = 27), or phosphate-buffered saline (PBS)(n = 16). Wounds were harvested on day 8 for histologic evaluation. Sections were examined for epithelial and granulation tissue ingrowth into wounds.Results:  HA- and HA/collagen-treated wounds showed statistically significant increases in epithelial (p = 0.003 and p = 0.007, respectively) and granulation tissue ingrowth (p = 0.004 and p = 0.01, respectively) when compared to PBS-treated controls.Conclusions:  In the rabbit ear ulcer model, the application of crosslinked HA and HA/collagen hydrogels accelerated wound healing as measured by epithelial and granulation tissue ingrowth.Funding Source: NIH grant: 5R01GM063825–03
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130216t.x
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  • 7
    Electronic Resource
    Electronic Resource
    Experimental deformation of partially melted granite revisited: implications for the continental crust (2005)
    Oxford, UK : Blackwell Science Inc
    Journal of metamorphic geology 23 (2005), S. 0 
    Details
    ISSN: 1525-1314
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: A review and reinterpretation of previous experimental data on the deformation of partially melted crustal rocks reveals that the relationship of aggregate strength to melt fraction is non-linear, even if plotted on a linear ordinate and abscissa. At melt fractions, Φ 〈 0.07, the dependence of aggregate strength on Φ is significantly greater than at Φ 〉 0.07. This melt fraction (Φ = 0.07) marks the transition from a significant increase in the proportion of melt-bearing grain boundaries up to this point to a minor increase thereafter. Therefore, we suggest that it is the increase of melt-interconnectivity that causes the dramatic strength drop between the solidus and a melt fraction of 0.07. We term this drop the ‘melt connectivity transition’ (MCT). A second, less-pronounced strength drop occurs at higher melt fractions and corresponds to the breakdown of the solid (crystal) framework. This is the ‘solid-to-liquid transition’ (SLT), corresponding to the well known ‘rheologically critical melt percentage’. Although the strength drop at the SLT is about four orders of magnitude, the absolute value of this drop is small compared with the absolute strength of the unmelted aggregate, rendering the SLT invisible in a linear aggregate strength v. melt-fraction diagram. On the other hand, the more important MCT has been overlooked in previous work because experimental data usually are plotted in logarithmic strength v. melt-fraction diagrams, obscuring large strength drops at high absolute strength values. We propose that crustal-scale localization of deformation effectively coincides with the onset of melting, pre-empting attainment of the SLT in most geological settings. The SLT may be restricted to controlling flow localization within magmatic bodies, especially where melt accumulates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1525-1314.2005.00555.x
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  • 8
    Electronic Resource
    Electronic Resource
    The influence of orthognathic surgery on masticatory performance in retrognathic patients (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 32 (2005), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: summary   Surgical correction of retrognathism may influence chewing performance and its underlying mechanisms selection and breakage of food particles. In this study we examined the hypothesis that treatment of this anomaly improves chewing performance. Furthermore, we determined to what extent this change can be attributed to selection and breakage of food particles. Eleven patients were tested before and 1–1·5 years after surgery. To determine chewing performance, eight cubes of 8 mm of a silicone rubber (Optosil®) were used as a test food. Selection and breakage were determined in one-chew experiments using three particle sizes. On average, no differences were found for chewing performance, selection or breakage. However, on an individual basis, patients with a poor chewing performance before surgery tended to improve, whereas no improvement was observed for patients with a good chewing performance. The change in chewing performance was mainly due to a change in breakage of the food particles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.2004.01436.x
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  • 9
    Electronic Resource
    Electronic Resource
    Genome-scale analysis of in vivo spatiotemporal promoter activity in Caenorhabditis elegans (2007)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 25 (2007), S. 663-668 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Differential regulation of gene expression is essential for cell fate specification in metazoans. Characterizing the transcriptional activity of gene promoters, in time and in space, is therefore a critical step toward understanding complex biological systems. Here we present an in vivo ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1305
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  • 10
    Electronic Resource
    Electronic Resource
    EMEA-US culture clash: resolving diversity issues through reflective evaluated action learning (2005)
    Bingley : Emerald
    Industrial and commercial training 37 (2005), S. 304-308 
    Details
    ISSN: 0019-7858
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: Purpose - Through a case study aims to describe an innovative methodology that was used to address intercultural miscommunication, which was threatening productivity in the global team of a US multinational service provider after a series of mergers and acquisitions. Design/methodology/approach - A methodology was designed to recognise the work pressure and time zone challenges of the global team. It used reflective evaluated action learning (REAL) to foster sustained, incremental learning in small, facilitated groups. The process of learning was evaluated in questionnaires, which tracked transference of learning into the workplace. There were adaptations such as the time frames of short meetings every two weeks, with ongoing charting of incidents. Findings - The longitudinal study quantitatively demonstrated transfer of learning into the workplace and qualitative analysis showed that the development of communication skills needs to be effective when working with other cultures. Specific business outcomes included company protocols for intercultural virtual communication. All skills were used regularly on evaluation nine months later. Practical implications - The REAL approach offered a time-efficient, effective solution to prevent an imminent intercultural breakdown in communication and morale in a pressurised corporate environment, and can be applied to a range of diversity issues. Originality/value - An innovative approach to cultural change was sustained and measured so that the process became more transparent. Traditional diversity and intercultural interventions are one-off and action learning has rarely been applied to tackle diversity issues or examine cultural behaviours and breakdowns. This was a unique approach to building the mindset and skills needed to work across cultural boundaries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/00197850510617587
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