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  • 1
    Digitale Medien
    Digitale Medien
    Chiral metal complexes. 4. Resolution of racemic tertiary phosphines with chiral palladium(II) complexes. The chemistry of diastereomeric phosphine palladium(II) species in solution (1977)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 99 (1977), S. 7876-7886 
    Details
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ja00466a020
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  • 2
    Digitale Medien
    Digitale Medien
    Poor metabolizer genotype status of CYP2C19 is a risk factor for developing gastric cancer in Japanese patients with 〈fr〉Helicobacter pylori〈/fr〉 infection (2005)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 22 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background : Cytochrome P450 2C19 (CYP2C19) polymorphism has been associated with the development of lung, liver or oesophageal cancer by detoxification of carcinogen(s) or activation of procarcinogen(s).Aim:  To clarify the association between CYP2C19 polymorphisms and gastric cancer development in Japanese.Methods : We determined CYP2C19 genotypes (CYP2C19*1, *2 and *3) in 111 Helicobacter pylori-positive patients with gastric cancer and 315 H. pylori-positive controls without gastric cancer consisting of patients with gastritis only or peptic ulcer. Frequencies of CYP2C19 genotypes and serum pepsinogen I and II levels, a biomarker of gastric atrophy, in the gastric cancers and controls were compared.Results : Frequencies of homozygous extensive metabolizers, heterozygous extensive metabolizers and poor metabolizers were 31.5%, 42.3% and 26.2% in the gastric cancers and 38.1%, 47.0% and 14.9% in the controls, respectively (P = 0.046). Poor metabolizers were associated with an increased risk for developing gastric cancer with the age- and sex-adjusted odds ratio (OR) of 1.975 [95% confidence interval (CI): 1.068–3.649], especially for diffuse type (OR: 3.385, CI: 1.187–9.648). There is no significant association between CYP2C19 genotypes and serum pepsinogen I level or pepsinogen I/II ratios, although serum pepsinogen I level in gastric cancers were significantly decreased.Conclusions : In H. pylori-positive Japanese, poor metabolizers of CYP2C19 appear to be at an increased risk for developing gastric cancer, especially diffuse type, and may require an intensive follow-up for scrutinizing possible gastric cancer development.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02678.x
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  • 3
    Digitale Medien
    Digitale Medien
    Effect of concomitant dosing of famotidine with lansoprazole on gastric acid secretion in relation to CYP2C19 genotype status (2005)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 22 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background : Famotidine increases Helicobacter pylori-eradication rates by a triple lansoprazole/amoxicillin/clarithromycin therapy in patients with the rapid extensive metabolizer genotype of CYP2C19.Aim : To determine the effect of famotidine on the gastric acid inhibition by lansoprazole in relation to CYP2C19 genotypes.Methods : Twenty healthy volunteers with different CYP2C19 genotypes – consisting of six rapid extensive metabolizers, nine intermediate metabolizers and five poor metabolizers – underwent three 7-day courses with placebo, lansoprazole 30 mg twice daily, and lansoprazole 30 mg twice plus famotidine 20 mg twice daily. Lansoprazole was dosed after breakfast and dinner. Famotidine was dosed after lunch and at bedtime. Intragastric pH monitoring was performed for 24 h on day 7 of each course.Results : With placebo, no difference was observed in intragastric pH profiles among the three CYP2C19 genotype groups. With lansoprazole 30 mg twice daily, the median of 24-h intragastric pH in poor metabolizers (6.1) was significantly higher than those of rapid extensive metabolizers (4.5) and intermediate metabolizers (5.0), respectively (P = 0.0176 and 0.0388), whereas with lansoprazole 30 mg twice and famotidine 20 mg twice daily, the medians were 5.4, 5.7, and 6.1, respectively (not significant).Conclusion : Acid inhibition by lansoprazole was influenced by CYP2C19 genotype status. This influence was offset by the concomitant use of famotidine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02523.x
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  • 4
    Digitale Medien
    Digitale Medien
    Antitumor activity of 1-alkylcarbamoyl derivatives of 5-fluorouracil in a variety of mouse tumors (1978)
    Springer
    Cancer chemotherapy and pharmacology 1 (1978), S. 203-208 
    Details
    ISSN: 1432-0843
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The antitumor properties of 1-alkylcarbamoyl derivatives of 5-fluorouracil were examined in various mouse tumor systems to select promising compounds for clinical use. Almost all alkylcarbamoyl derivatives were active against various tumors when given by oral administration. Among them, 1-methyl, 1-ethyl, 1-isopropyl, 1-hexyl and 1-octyl carbamoyl derivatives of 5-fluorouracil were moderately or markedly active in six mouse tumor systems tested. However, 1-methyl, 1-ethyl, and 1-isopropyl carbamoyl derivatives were toxic to mice, though not lethal. As a result, 1-hexyl and 1-octyl carbamoyl derivatives were selected as the best candidates for antitumor agents in further study.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00257150
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  • 5
    Digitale Medien
    Digitale Medien
    Dislocation Structure of 10° Low-Angle Tilt Grain Boundary in α-Al〈sub〉2〈/sub〉O〈sub〉3〈/sub〉 (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 558-559 (Oct. 2007), p. 979-982 
    Details
    ISSN: 1662-9752
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Notizen: Dislocation structure of 10º low-angle tilt grain boundary in α-Al2O3 has been observed byhigh-resolution electron microscopy (HRTEM). It was found that perfect 〈1120〉 edge dislocations,which are introduced to compensate the misorientation, dissociated into two mixed partialdislocations with {1120} stacking-fault in between. The distances between the two partials wereestimated by the force balances between repulsive forces of periodical dislocations and attractiveforces from stacking-fault. The stacking-fault energy for 10o low-angle tilt grain boundary wasestimated to be much higher than the previously reported value
    Materialart: Digitale Medien
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/17/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.558-559.979.pdf
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  • 6
    Digitale Medien
    Digitale Medien
    Quantitation of sulfur-containing oil compounds and polychlorinated biphenyls (PCBs) in sediments from waters of the Osaka Port area (1979)
    Springer
    Archives of environmental contamination and toxicology 8 (1979), S. 563-571 
    Details
    ISSN: 1432-0703
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik , Medizin
    Notizen: Abstract Sediments were periodically collected from the waters of the Osaka Port area during the period of 1970 to 1977 and analyzed for oil pollutants and polychlorobiphenyls (PCBs). Sulfur-containing oil components and PCBs were most noticeable in the vicinity of the mouth of the Shirinashi River and they originated from discharges and/or dumping into the river. Analyses indicated that the sulfur-containing materials were derived from a Class C heavy oil, and were present in the sediments in a range of 0.49 to 7.5 ppm (dry basis). PCB residues ranged from 0.45 to 4.0 ppm.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01055037
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  • 7
    Digitale Medien
    Digitale Medien
    A comparison of acidic glycosaminoglycans in the inner ear and other organs: Electrophoretic microanalysis (1976)
    Springer
    European archives of oto-rhino-laryngology and head & neck 214 (1976), S. 149-155 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Acidic glycosaminoglycans in inner ear and other organs ; Electrophoretic microanalysis ; Saure Glykosaminoglykane im Innenohr und anderen Organen ; Elektrophoretische Mikroanalyse
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Die quantitative und qualitative Analysen der sauren Glykosaminoglykane in den Grundsubstanzen der lateralen Wand des häutigen Labyrinths, der Nieren, des Gehirns und der Leber von Meerschweinchen wurden mittels der elektrophoretischen Mikroanalysenmethode ausgeführt. Die laterale Wand der Schnecke enthielt die höchste Menge (0,46±0,08% pro Trockengewicht) der sauren Glykosaminoglykane, die aus Chondroitinsulfat-B (75%), Chondroitinsulfat-A (12%) und Hyaluronsäure (13%) bestanden. Jedoch schwankt die Zusammensetzung der Glykosaminoglykane im Innenohr, ebenso wie in den anderen Organen, erheblich. Eine mögliche Bedeutung der Glykosaminoglykane für die Funktion des Hörorgans wurde diskutiert.
    Notizen: Summary Acidic glycosaminoglycans in the ground substance of the membranous cochlear lateral wall, kidney, brain and liver of the guinea pigs were quantitatively and qualitatively analyzed, using electrophoretic microanalysis. The lateral wall of the cochlea showed highest content (0.46±0.08%/D.W.) of acidic glycosmainoglycans, which were chondroitin sulfate-B (75%), chondroitin sulfate-A (12%) and hyaluronic acid (13%). However, the pattern of these acidic glycosaminoglycans in the inner ear differed from the other organs. A possible role of acidic glycosaminoglycans in the inner ear was discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00453611
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  • 8
    Digitale Medien
    Digitale Medien
    The coagulation of particles in suspension by freezing-thawing II. Mechanism of coagulation (1976)
    Springer
    Colloid & polymer science 254 (1976), S. 497-506 
    Details
    ISSN: 1435-1536
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Der Mechanismus der Gefrierkoagulation von Partikeln in Suspension wurde diskutiert, und die Ursache, weshalb feine Partikel zur Koagulation neigen, wurde erläutert. Die Koagulation steigt mit dem Wachstum der Eiskristalle, und die Treibkraft für die gegenseitige Annäherung der Partikel wird der aus dem Wachstum der Eiskristalle entstehenden Druckkraft zugeschrieben. Eiskristalle wachsen bei langsamem Gefrieren, Wasser wird aus den Zwischenräumen der Partikel gedrückt, die Partikel sammeln sich in den Zwischenräumen der Eiskristalle an und nähern sich einander so weit, daß es infolge van der Waalsscher Kräfte zur Koagulation kommt. Die Bindung der Partikel in den Koagulationen wurde theoretisch diskutiert. Bei großen Partikeln ist sie so gering, daß das Koagulat sehr wahrscheinlich brüchig und wenig stabil ist. Die Energieschwelle zwischen den Partikeln wird mit wachsender Partikelgröße größer, weshalb mehr Energie erforderlich ist, um große Partikel für Koagulation nahe genug aneinander zu bringen: große Partikel koagulieren nicht so leicht wie kleine.
    Notizen: Summary The mechanism of the freeze-thaw coagulation of the particles in suspension was discussed and the reason for the tendency for fine particles to produce coagulates was elucidated. The coagulation increases with the growth of ice crystals and the driving force for particle approach is attributed to the push force arising from the growth of ice crystals. Ice crystals grow on slow freezing, and water is squeezed from the interstices of the particles, consequently particles are pushed aside by ice crystals and collected in the interstices of the ice crystals. Further freezing and hence, dehydration from the suspended particle groups allow these particles to approach each other very closely and they form coagulates by van der Waals forces. The strength of the coagulates was also discussed theoretically. In the case of large particles, the strength of the coagulate was so small that the coagulate is likely to be fragile and has difficulty in remaining intact even after the particles have aggregated. From the viewpoint of the potential energy between particles, the energy barrier becomes greater as the particle size increases and hence, more energy is required for bringing large particles close enough for coagulation, and thus, large particles do not coagulate as easily as small ones.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01410917
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  • 9
    Digitale Medien
    Digitale Medien
    The coagulation of particles in suspension by freezing-thawing (1977)
    Springer
    Colloid & polymer science 255 (1977), S. 343-356 
    Details
    ISSN: 1435-1536
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Die Gefrierkoagulation kann verhindert werden durch die Beibehaltung von nicht gefrorenem Wasser, was durch den Zusatz von hydrophilen Substanzen zu den Suspensionen erreicht wird. Je größer der Anteil des nicht gefrorenen Wassers ist, um so geringer ist die Koagulation, und je stärker die hydrophile Eigen schaft des Additivs ist, um so größer ist der Anteil des nicht gefrorenen Wassers. Es wurde weiterhin klargestellt, daß es drei Faktoren für die wirksame Verhüg der Koagulation gibt: (A) die Gegenwart großer Mengen nicht gefrorenen Wassers, (B) ein kurzes Plateau an der Gefrierkurve, falls vorhanden, (C) kleine bleibende Eiskristalle. Sie sind in ihrem Mechanismus der Koagulationsverhütung identisch, nämlich der Verhütung der Koagulation durch die Kontrolle des Wachstums der Eiskristalle. Theoretische Berechnungen der Abstände zwischen Partikeln bei gleicher Konzentration der Lösung zeigen, daß kleine Partikeln leichter als große Partikeln koagulieren.
    Notizen: Summary Freeze-thaw coagulation can be prevented by keeping unfrozen water which is attained by adding hydrophilic substances to the suspension. The effectiveness is due to the prevention of the growth of ice crystals due to the existence of unfrozen water, thus the approach of particles due to crowding from growing ice crystals is suppressed. The greater the proportion of the unfrozen water, the lesser the coagulation, and the stronger the hydrophilic property of the additive, the greater proportion of residual unfrozen water. It was also clarified that there were three factors, all of which were useful for preventing coagulation: namely, (A) the presence of large amounts of unfrozen water, (B) a short plateau on the freezing curve, if present, (C) the presence of small residual ice crystals. These were identical in their mechanism for preventing coagulation, namely the prevention of coagulation by controlling ice crystal growth. Theoretical calculations of the distances between particles at the same suspension concentration showed that small particles coagulate more easily as compared with large ones.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01773531
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  • 10
    Digitale Medien
    Digitale Medien
    An experimental investigation of viscoplastic flow past a circular cylinder at high Reynolds numbers (1975)
    Springer
    Rheologica acta 14 (1975), S. 993-1000 
    Details
    ISSN: 1435-1528
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Physik
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Die vorliegende Arbeit befaßt sich mit der Untersuchung der Umströmung eines Kreiszylinders durch eine visko-plastische Flüssigkeit mit hoher Geschwindigkeit. Hierin eingeschlossen sind die Messung der mittleren Längenausdehnung des „Totwasser“-Gebiets sowie der Druck- und Temperaturverteilung über die Zylinderoberfläche. Die zeitlich gemittelte Längserstreckung des „Totwasser“-Gebiets stellt sich als eine für das visko-plastische Fließen charakteristische Größe heraus: Sie kommt erheblich größer heraus als fürnewtonsche Flüssigkeiten unter vergleichbaren Bedingungen. Man findet weiterhin am Zylinder anliegende stationäre Flüssigkeitsbereiche, welche die Wärmeübertragung zwischen Zylinder und Flüssigkeit sehr hemmen.
    Notizen: Summary The purpose of this work was to examine the high speed flow of viscoplastic fluid past a circular cylinder. Included in this work were measurements of the time-averaged wake length and the pressure and temperature distributions over the cylinder surface. The time-averaged wake length was very characteristic of viscoplasticity: The viscoplastic flow showed quite longer wake length than theNewtonian flow under certain conditions. It was found that there were the regions of stationary fluids adjacent to a cylinder and that they obstructed the heat transfer between the cylinder and fluid very much.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01516302
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