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  • 2005-2009  (2)
  • 1930-1934  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Bone Marrow Mesenchymal Stem Cells: From Characterization of Neural Differentiation to a Possible Therapeutic Use in Neurodegeneration (2005)
    Berlin, Germany : Blackwell Verlag GmbH
    Anatomia, histologia, embryologia 34 (2005), S. 0 
    Details
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Bone marrow derived stromal cells are of mesenchymal origin and precursor cells for skeletal tissue components such as chondroblasts and osteoblasts. Furthermore, under experimental conditions, a differentiation potency into myogenic and neuronal cells could be demonstrated. Because of their multipotency these cells represent a population of non-haematogen stem cells that can be regarded as an alternative to human embryonic stem cells for future autologous cell replacement therapies. For a closer look at the differentiation capacity of these cells, rat and human bone marrow stromal cells were isolated from the femur bone and kept in the cell culture applying different cultivation protocols. In a cultivation medium with a serum content of 20%, the majority of these cells express a variety of neuronal markers such as ß-III Tubulin and NeuN as well as the astrocyte marker GFAP, while a minority of about 20% express the marker for neural precursor cells nestin. Cultivation in a chemically defined serum free medium results in the differentiation of a markedly higher percentage of nestin positive neural precursor-like cells. Using bFGF in combination with B27 these cells can be forced to form three dimensionally organized spheres. In order to elucidate a possible therapeutical potency of the bone marrow derived cells the synthesis of neurotrophic factors such as BDNF and NGF were analysed using the ELISA technique. Furthermore, they can be infected using a third generation adenoviral vector with high efficiency and show migratory activity in vitro. After injection of bone marrow derived mesenchymal stem cells into the lateral ventricle of adult rats they adhere to the ependymocytes and pass the ependymal barrier in order to settle in the subventricular space.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0264.2005.00669_10.x
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  • 2
    Electronic Resource
    Electronic Resource
    GP IIb-IIIa Receptor Blockers Minimize Vascular and Perivascular Damage in the Hippocampus after Cardiopulmonary Bypass Management (2005)
    Berlin, Germany : Blackwell Verlag GmbH
    Anatomia, histologia, embryologia 34 (2005), S. 0 
    Details
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Brain injury remains a significant and potentially devastating outcome of cardiopulmonary bypass (CPB) under circulatory arrest. These outcomes caused by a microvasculature embolization are associated with increased mortality, longer hospital stays and increased use of intermediate or long term care facilities. The administration of heparin in heart surgery during deep hypothermic cardiopulmonary bypass is the basic prophylactic strategy for reducing or even preventing, microvasculature embolization. Unfortunately, an incidence of neuropsychological impairments (NPI) is found in as many as 25 % of the survivors. As it is suspected that these impairments are correlated with morphological alterations, in our study we use the GP IIb-IIIa receptor blocker Eptifibatide for the inhibition of platelet aggregation, in order to look for a reduction of tissue damage compared to the standard treatment. Two groups of 11 piglets (mean body weight of 15±5 kg) underwent 10-minute normothermic bypass, 40-minute cooling on cardiopulmonary bypass, 60-minutes deep hypothermic circulatory arrest (DHCA) at 15°C, and 40-minute rewarming to 37°C. Group 1 was treated only with unfractionated heparin (UFH), whereas Group 2 was medicated with Eptifibatide, in addition to the UFH-treatment group 1. After rewarming, all animals underwent bilateral carotid perfusion with 4% paraformaldehyde. Histological investigations of semi thin sections reveal a marked decrease of hippocampal alterations by using the GP IIb-IIIa receptor blocker in addition to standard UFH treatment. We detect a reduction of degenerative areas in perivascular (vessels with 10–30 μm in diameter) tissue. These semi-quantitative data are confirmed by ultrastructural findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0264.2005.00669_11.x
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  • 3
    Electronic Resource
    Electronic Resource
    Zur Pathogenese der Psoriasis vulgaris. Die Rolle der Masern bei ihrer Entstchung (1932)
    Springer
    Archives of dermatological research 167 (1932), S. 114-122 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Individuen, die Masern überstanden haben, erkranken seltener an Psoriasis als nichtgemaserte. Bei 200 Psoriatikern ergab die Anamnese unter Ausschluß möglichst aller Fehlerquellen in 103 Fällen eine überstandene Maserninfektion, bei 200 Kontrollen in 154 Fällen (51,5% : 77%). Kontinuierlich, d.h. ohne wesentliche Remissionen bestehende Psoriasis fand sich häufiger bei nicht gemaserten Patienten (32: 17, bezogen auf 200). Die Rezidivhäufigkeit war ebenfalls bei masernnegativen Psoriatikern größer als bei masern-positiven (232 Rezidiven bei 65 Patienten zu 164 Rezidiven bei 86 Patienten=3 1/2:2 Rezidiven pro Patient). Zur Deutung dieser Verhältnisse wird angenommen, daß die Masern der Haut eine bestimmte Schutzfunktion gegenüber Psoriasis verleihen, die wir auf den Umstand zurückführen, daß sowohl Masern wie auch Psoriasis Einschlußkrankheiten sind. Die Annahme dieser Schutzfunktion wird vielleicht durch die in der Literatur niedergelegte, günstige Beeinflussung oder Heilung mehrerer Psoriasisfälle durch interkurrente Masern gestützt, ferner auch durch einige statistische Daten bei der Kinder- und Greisenpsoriasis. Der Versuch der Beeinflussung einiger Psoriasisfälle durch Masern-rekonvaleszentenserum blieb — unseren Erwartungen entsprechend — erfolglos. Blutkulturen auf Tuberkulose ergaben bei 20 Psoriasisfällen negative Resultate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02058488
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  • 4
    Electronic Resource
    Electronic Resource
    Über die Temperaturabhängigkeiten von Insekten (1930)
    Springer
    Journal of comparative physiology 11 (1930), S. 345-385 
    Details
    ISSN: 1432-1351
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00338215
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  • 5
    Electronic Resource
    Electronic Resource
    Zur Lebensgeschichte und Epidemiologie der GetreidemotteSitotroga cerealella Oliv (1930)
    Springer
    Journal of pest science 6 (1930), S. 97-101 
    Details
    ISSN: 1612-4766
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Zusammenfassung Die GetreidemotteSitotroga cerealella Oliv. entwickelt in der palästinensischen Küstenzone jährlich 5–6 Generationen. Der Entwicklungsnullpunkt liegt bei 10,3° C, die Thermalkonstante beträgt 474°. Die Eizahl schwankt zwischen 80 und 180 pro ♀, die Verteilung der Geschlechter ist wie 1∶1. Während das Entwicklungspotential einesSitotroga-Pärchens bei 6 Generationen in einem Jahr über 30 Milliarden Motten betragen müßte, beträgt die tatsächliche Nachkommenziffer eines Pärchens im Laufe eines Jahres unter den klimatischen Bedingungen der palästinensischen Küstenebene nur 400–450 Motten. Durch die extremen Temperaturen im Winter und Sommer wird die Zahl der Tiere derart reduziert, daß ihre Zahl im neuen Jahr von der des Vorjahres nicht sehr variiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02338247
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