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Open Wound Integrated Regenerative Therapy with Topical bFGF Trafermin for Deep Soft Tissue Defects with Bone Exposure (2005)

Ohura, N ; Ichioka, S ; Asano, T ; [et al.]

Oxford, UK; Malden, USA : Blackwell Science Inc

Wound repair and regeneration 13 (2005), S. 0

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ISSN: 1524-475X

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Aim: Recently advocated concept of wound bed preparation (WBP) has systematically concreted the critical components of wound care, including debridement, bacterial balance, and management of exudate. We succeed in experiences by topical pharmaceutical therapy combined with WBP. We aimed to demonstrate availability of the wound management.Methods: Since 1999, 18 exteriorized-bone patients with deep soft tissue defects were treated with this treatment. Our procedure was composed of four steps; 1) Resection or debridement, 2) Wound cleansing (soaking foot and hand in the hot bath with antibacterial carbonated agent), 3) Topical medication: basic fibroblast growth factor (Trafermin; KAKEN, Tokyo) and bucladecine sodium (Actocin ointment; Daiichi Pharmaceu. Co. Ltd, Tokyo), and 4) Dressing.Results: The average time for whole coverage of the exposed-bone area with healthy granulation was 23 ± 13( median;19, range; 7–47) days after surgical treatment (the 1st step). The average time for complete epithelization was 72 ± 42 (55, 26–150) days in the patients who had not undergone skin graft. For minor amputations of diabetic feet the healing time until complete epithelization was 65 ± 46 (44, 26–150) days on an average.Conclusions: We concluded that the integrated approach mobilizing commercial available products for wound healing under optimally prepared environment offers advantage of facilitating the efficacy of exogenous therapeutic measures on condition that endogenous regeneration has been accelerated.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130116al.x

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Zirconia Knee Wear and Raman Spectroscopy Studies Compares 3.5-Mrad and 7-Mrad UHMWPE Inserts (2006)

Tsukamoto, R. ; Pezzotti, Giuseppe ; Ogino, M. ; [et al.]

s.l. ; Stafa-Zurich, Switzerland

Key engineering materials Vol. 309-311 (May 2006), p. 1285-1288

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ISSN: 1013-9826

Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Notes: We studied the long-term wear behaviour of alumina-doped zirconia femoral condyles against ultra-high molecular weight polyethylene (UHMWPE) tibial inserts. The simulator kinematics included 20 degrees of flexion/extension, ± 5 degrees of internal/external rotation, and 6 mm of anterior/posteriortranslation. All knee components were subjected to 10 million cycles of normal walking (2.6 KN max, freq. 1.8 Hz). Lubricant was 50% alpha-calf serum (20 mg/ml protein) with EDTA. The tibial inserts were from one lot of ram-extruded UHMWPE and sterilized with 3.5-Mrad or 7-Mrad radiation dose. Soak controlswere stored unloaded in deionised water for 60 days prior to testing. Implants were studied with high-resolution confocal Raman spectroscopy after 10-Mc duration. The wear of control knees (CoCr/3.5-Mrad) averaged 4.5mm3/Mc while the wear with the ZrO2/7-Mrad combination was unmeasurably low even after 10 million cycle duration. Raman Spectroscopy at 10-Mc duration showed only the presence of the desired tetragonal phase. Thus, the ZrO2/7-Mrad bearing combination shouldprove excellent for active patients who may otherwise risk high wear rates over many years of use