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  • 2005-2009  (5)
  • 1
    Electronic Resource
    Electronic Resource
    Id helix-loop-helix proteins are differentially expressed in gestational trophoblastic disease (2005)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 47 (2005), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims : To assess the expression of Id proteins in trophoblastic tissues and to correlate this with clinical parameters, proliferative and apoptotic indices as well as to related oncogene expression.Methods and results : Immunohistochemistry for Id1, Id2, Id3 and Id4 was performed on 83 trophoblastic tissues including 17 normal first-trimester placentas, seven term placentas, 47 hydatidiform moles (HM), and 12 spontaneous miscarriages. The four Id proteins were predominantly expressed in the villous and implantation site intermediate trophoblast. Expression of Id1 in HM was significantly higher than that in normal placenta (P = 0.0006) and spontaneous miscarriage (P = 0.0001) but did not correlate with subsequent development of gestational trophoblastic neoplasia (GTN). Id1 expression correlated with the proliferation index as assessed by MCM7 (P = 0.003) and Ki67 (P = 0.017) and with the apoptotic activity assessed by TUNEL (P = 0.001) and M30 CytoDeath antibody (P = 0.013). Moreover, the expression of Id1 correlated with the expression of p53 (P = 0.004), p21WAF1/CIP1 (P = 0.003) but not with p16 (P = 0.107).Conclusions : Id proteins may play a role in the regulation of proliferative and apoptotic activity in trophoblastic tissue and are potentially useful in differentiating molar and non-molar gestation, but are not helpful in predicting GTN.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2005.02190.x
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  • 2
    Electronic Resource
    Electronic Resource
    Comparison of the prolonged swimming performances of closely related, morphologically distinct three-spined sticklebacks Gasterosteus spp. (2005)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Journal of fish biology 67 (2005), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Prolonged swimming performances of two as yet unnamed species of three-spined stickleback, Gasterosteus spp., were compared. The two fishes (not yet formally described, referred to here as benthic and limnetic) inhabit different niches within Paxton Lake, Texada Island, British Columbia, Canada, and are recent, morphologically distinct species. Limnetics had longer endurance during prolonged swimming than did benthics. The mean regression of the log10 of fatigue time (Ft, s) on swimming speed (U, standard length, LS s−1) for limnetics (log10Ft = 7·03 − 0·46U) had a similar slope, but a significantly higher intercept than that for benthics (log10Ft = 5·55 − 0·43U). Adult benthics were larger, heavier and deeper-bodied fish than limnetics. Limnetics, however, had a significantly greater pectoral fin edge:base ratio (mean ± s.e.: limnetics, 4·58 ± 0·43; benthics, 3·63 ± 0·27). In addition, limnetics had significantly lower drag coefficients (CD) than benthics (limnetics, log10CD = −0·49log10Re + 0·66; benthics, log10CD = −0·26log10Re − 0·30) where Re is the Reynolds number [(LSU (ν−1), where U and ν are swimming velocity and the kinematic viscosity of the water, respectively]. Compared to their ancestral form, the anadromous three-spined stickleback Gasterosteus aculeatus L., limnetics and benthics had significantly longer and shorter endurance times, respectively. In addition, both these fishes had significantly higher fast-start velocities than their ancestral form. Selection due to differential resource use may have lead to divergence of body form, and, therefore, of steady swimming performance. Therefore predation may be the selective force for the similar high escape performance in these two fishes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0022-1112.2005.00788.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Finlets and the steady swimming performance of Thunnus albacares (2005)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Journal of fish biology 67 (2005), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The functional significance of finlets on the steady swimming performance of yellowfin tuna Thunnus albacares was evaluated by measuring the speed and tail-beat frequency of the fish with and without them. It was hypothesized that if finlets do improve swimming performance, fish without finlets would have to work harder to maintain the same swimming speed as fish with them and that this would be reflected in kinematic differences. Two-way ANOVA showed significant effects between individuals on speed (d.f. = 5 and 228, P 〈 0·001) and tail-beat frequency (d.f. = 5 and 48, P 〈 0·001), but no significant effects of treatment on speed (d.f. = 1 and 228, P = 0·25) and tail-beat frequency (d.f. = 1 and 48, P 〉 0·1). No interaction effects on speed (d.f. = 5 and 228, P 〉 0·1) and tail-beat frequency (d.f. = 5 and 48, P 〉 0·25) were found. This suggested that finlets were unlikely to function as significant drag reduction and thrust enhancing devices in routine steady swimming. Though not statistically significant, small percentage differences between the mean swimming speeds and tail-beat frequency of the untreated and treated groups (fish with and without finlets respectively) of the order of 0·5% may be meaningful over the life of a fish. Also, finlets may improve performance at high sustained speeds in rapid accelerations and turns.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.2005.00852.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Replicative MCM7 protein as a proliferation marker in endometrial carcinoma: a tissue microarray and clinicopathological analysis (2005)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 46 (2005), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims : To assess, in tissue microarray (TMA), the proliferative activity of endometrial carcinoma using one of the minichromosome maintenance (MCM) proteins (MCM7), and to explore its potential value for prognosis. MCM proteins are essential for eukaryotic DNA replication and have recently been used to define the proliferative compartments in human tissues.Methods and results : Immunohistochemistry for MCM7 and Ki67 was performed on TMAs constructed from 212 cases of endometrial carcinoma. MCM7 and Ki67 expression was quantified according to the extent of nuclear staining. An analysis was carried out of the association between MCM7 expression and that of Ki67 and the clinicopathological characteristics of endometrial carcinoma. MCM7 and Ki67 immunoreactivity was clearly evident in the nuclei of tumour cells. MCM7 and Ki67 labelling indices in endometrial carcinomas correlated with each other (P 〈 0.001). A significant correlation existed between the MCM7 labelling index and histological grade (P = 0.008) and patients' age at diagnosis (P 〈 0.001). Well-differentiated carcinomas and younger patients had a lower MCM7 index. Poor survival was observed in patients with endometrial carcinoma with a high MCM7 index (P = 0.03) and MCM7 was found to be an independent prognostic factor by multivariate analysis (P = 0.04). The Ki67 labelling index correlated with histological grade (P = 0.01) but had no significant prognostic impact (P = 0.50).Conclusions : In this TMA study on endometrial carcinoma, MCM7 was found to be a more reliable and useful marker than Ki67 in assessing tumour proliferation and in the prognosis of patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2005.02069.x
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  • 5
    Electronic Resource
    Electronic Resource
    Nitrite-induced methaemoglobinaemia – aetiology, diagnosis and treatment (2005)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 60 (2005), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 41-year-old woman presented with the clinical features of methaemoglobinaemia after drinking Chinese herbal medicine. A life threatening methaemoglobin level of 68% was measured. Both clinical and laboratory diagnostic difficulties were encountered. The pitfalls of pulse oximeter, blood gas analysis and co-oximeter interpretation during diagnosis and after methylene blue administration are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.2004.04076.x
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