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  • 2005-2009  (6)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Glutathione protects human airway proteins and epithelial cells from isocyanates (2005)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 35 (2005), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Glutathione (GSH), one of the major anti-oxidants of the lung, has been linked to the human response to isocyanate exposure. However, the ability of GSH to modulate key chemical reactions, thought to be central to the development of human isocyanate allergy, has not been directly analyzed under biologic exposure conditions.Objective To better understand the potential role of GSH in the response to occupational isocyanate exposure, we evaluated its effects on two processes thought to be involved in the development of isocyanate allergy, isocyanate–protein conjugation and epithelial cell toxicity.Methods The effects of GSH on (1) isocyanate conjugation with albumin, its major target in the airway fluid and (2) isocyanate-induced toxicity to human airway epithelial cell lines, A549 and NCI-H292, were tested using two different in vitro models. For protein conjugation studies, a newly described vapour exposure system was used to model the air/liquid interface at the surface of the epithelial fluid in the airways. Epithelial cell exposures were performed in fluid phase to mimic the in vivo exposure of airway cells covered by epithelial lining fluid.Results Reduced GSH prevented hexamethylene diisocyanate (HDI) conjugation to albumin in a dose-dependent manner, while oxidized GSH (GSSG) conversely increased conjugation rates. GSH levels equivalent to those found in normal human airway fluid (100 μm) provided 〉90% protection against HDI-protein conjugation when albumin was exposed to HDI vapour levels 10-fold above permissible occupational limits. Physiologic levels of GSH, but not GSSG, also reduced HDI toxicity to human airway epithelial cells in a dose-dependent manner, when present extracellularly, however, drugs that modulate intra-cellular GSH levels did not significantly alter isocyanate toxicity.Conclusions Together with previously reported genetic and toxicity studies, the data suggest that airway GSH plays an important role in protection against HDI exposure and may help prevent the development of allergic sensitization and asthma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2005.02185.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Secretory expression of recombinant proteins in an attenuated Vibrio anguillarum strain for potential use in vaccines (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of fish diseases 28 (2005), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Vibrio anguillarum is an important bacterial fish pathogen responsible for epizootics in both marine and freshwater fish worldwide. Studies on pathogenic V. anguillarum has shown that its virulence is mediated by a 65 kb endogenous pJM1-like plasmid, which encodes an efficient iron uptake system. The plasmid-free derivative of wild V. anguillarum was found to be greatly attenuated and elicited a good protection against wild V. anguillarum in fish. In this study, a plasmid-free derivative MVAV6201, an effective live vaccine candidate, was used as a carrier strain to achieve the secretory delivery of recombinant proteins in V. anguillarum. The secretion mechanism was based on the Escherichia coliα-haemolysin (HlyA) transport system. The recombinant proteins were fused with the α-haemolysin secretion signal (HlyAs) and expressed from the commonly used HlyA secretion vector pMOhly1. Two HlyAs-tagged recombinant proteins, GFP-HlyAs and AngE-HlyAs, were constructed and their secretion characters in V. anguillarum investigated. In the case of GFP-HlyAs, nearly 70% of the total fusion protein was efficiently secreted into culture supernatant, and in the case of AngE-HlyAs, the secretion efficiency was determined to be about 300 μg L−1 by Western blotting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.2005.00679.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Surface Optimizing Behaviour of Nano-Cu Lubricant to Tribosurfaces by Mechanochemical Process (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 339 (May 2007), p. 223-227 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A special kind of surface modified copper nanoparticles was selected as theauto-reconditioning materials to in situ generate a copperized protective film on iron-base metalsurfaces under designed tribological conditions. The morphologies and element distributions of theformed film were observed and determined by scanning electron microscopy (SEM) and energydispersive spectrometry (EDS). The micro mechanical properties and tribological behaviors wereinvestigated by nano test system and ball-on-disc tribotester. The results show that the morphologyof the protective film is smooth, the nano-hardness decreases by 46% and the friction coefficient ofthe copperized protective film is about 0.10. The forming mechanism of the auto-reconditioningfilm can be described that the copper nanoparticles deposit on the worn surfaces and formiron-copper alloy film with lower hardness and shear strength, which has better friction-reducing,antiwear and surface-optimizing behaviors
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.339.223.pdf
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  • 4
    Electronic Resource
    Electronic Resource
    Thermal Vibration Characteristics Analysis of a Composite Thin-Cylindrical Shell Embedded with Shape Memory Alloy Wires (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 334-335 (Mar. 2007), p. 933-936 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Thermal vibration characteristics of the composite thin-cylindrical shell embedded withshape memory alloy (SMA) fibers are investigated. The shape memory alloy material behavior isprogrammed in the form of an ABAQUS user subroutine code (UMAT), and this program issuccessfully verified by using the response of pseudoelasticity and the shape memory effect (SME) atvarious temperatures and stress levels. Based on the ABAQUS UMAT code, the natural frequency ofthe composite thin-cylindrical shell embedded with SMA wires under thermal load and mechanicalload is calculated respectively. Then the effects of the SMA wire temperature and the content on thethermal vibration characteristics of the structure are discussed. Numerical simulation results showthat the temperature and the volume content of the SMA wires increase the stiffness and bucklingcritical load of the structure
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.334-335.933.pdf
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    High Speed Lapping Ellipsoid by Means of a Lapping Tool Bending Method (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 329 (Jan. 2007), p. 309-314 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This paper discusses a new lapping ellipsoid method, which combines high-speedlapping technology with solid abrasives and lapping tool bending method. In this method, a bendingmoment is acted on lapping tool with solid abrasives, which makes it bend to form a shape on itsworking surface, which is the same as generant of workpiece shape. This kind tool is used informing lapping on a high speed lapping machine.With the development of science and technology, the requirements for optics systems becomehigher and higher, e.g. good quality of imaging, little loss light energy, small size and light weightetc. It is difficult to reach above requirements by using traditional sphere lens/mirrors in opticssystems. Aspheric optics elements can be used to solve these problems. In optics systems, by usingaspheric optics elements, the number of optics elements can be reduced, the system structure can besimplified, the weight and size of the system can be reduced, light energy loss can be reduced too,imaging errors can be avoided and imaging quality can be improved. Ellipsoid is a kind of surfacebeing used widely within all kinds of aspheric surfaces. The main purpose of this paper is tointroduce a method of lapping this kind of surface at high speed
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/52/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.329.309.pdf
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Free Vibration Analysis of Composite Structure under Thermal Condition (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 334-335 (Mar. 2007), p. 973-976 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A nonlinear thermal vibration characteristic of the laminate composite thin shell structuresunder linear temperature field is investigated by finite element method (FEM). The naturalfrequencies of the composite laminated thin shell structures with different boundary conditions andstacking sequence are calculated and analyzed. Numerical results show that the natural frequencies ofthe structure are affected by the temperature, boundary conditions and the stacking sequence; theproper stacking angle can change the natural frequencies; the effect degree on the natural frequenciesof symmetric composite structures is different from that of the antisymmetric one. These conclusionscan provide some guidance to structure design and heat-resistant design of composite structures
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.334-335.973.pdf
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