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Temperature and Strain Rate Effects on Plastic Deformation of Titanium Alloys (2007)

Ogawa, K.

s.l. ; Stafa-Zurich, Switzerland

Materials science forum Vol. 539-543 (Mar. 2007), p. 3619-3624

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ISSN: 1662-9752

Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Notes: Since titanium alloys are the most promising structural materials for the high velocityvehicles, the impact tensile strength of the materials is presently investigated. Three kinds ofaging treatments on the beta-titanium alloy were performed, and the tensile deformation behaviorswere identified in the wide range of the temperature and the strain rate. The stress－strain relationsof the titanium alloy significantly depend on the temperature and the strain rate investigated.Thermally activated process concept was applied to explain the experimental results, and thestress-strain relations at high strain rates were well understood with taking account of adiabaticheating effect. It has been found that the stress-strain curves depend on the microstructures, whilethe temperature and the strain rate effects are almost independent of the different aging treatments

Type of Medium: Electronic Resource

URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/15/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.539-543.3619.pdf

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Increase in killer-specific secretory protein of 37 kDa in bronchoalveolar lavage fluid of allergen-challenged patients with atopic asthma (2005)

Kuepper, M. ; Bratke, K. ; Julius, P. ; [et al.]

Oxford, UK : Blackwell Science Ltd

Clinical & experimental allergy 35 (2005), S. 0

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ISSN: 1365-2222

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Background Atopic asthma is linked to a T-helper type 2 dominated pathogenesis, but there is increasing evidence of Th1/Tc1-mediated processes in the aetiopathology of asthma. Killer-specific secretory protein of 37 kDa (Ksp37) is expressed in cytotoxic lymphocytes, selectively in the effector subsets of CD8+- and CD4+ T lymphocytes and in CD16+/CD56dim natural killer cells and γ/δ T cells. This effector cell-specific expression of Ksp37 and its coexpression with perforin suggest that Ksp37 might be involved in processes mediated by cytotoxic cells.Objective We hypothesize that Ksp37 could indicate the involvement of cytotoxic lymphocytes in the pathogenesis of atopic asthma, and investigated Ksp37 concentration in bronchoalveolar lavage fluid (BALF) collected 10 min, 18, 42 or 162 h after segmental allergen provocation and in serum of patients with atopic asthma (n=25).Methods Ksp37 concentrations in BALF and serum were detected by ELISA. Flow cytometric analysis was used to assess numbers and cell subsets in BALF.Results Ksp37 increased significantly in BALF 10 min, 18 and 42 h, but not 162 h after allergen challenge compared with saline-challenged controls, while Ksp37 serum levels did not change significantly at all time-points. In addition, the increase in Ksp37 concentrations in BALF correlated with the corresponding numbers of lymphocytes.Conclusions We conclude that Ksp37 level increased in BALF 10 min, 18 and 42 h after allergen challenge but not in peripheral blood. Our findings suggest that segmental allergen challenge in asthma is associated with an increase in Ksp37 concentrations in BALF and an influx of potentially cytotoxic T lymphocytes into the lungs.