ISSN:
1439-0264
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Borna disease virus (BDV) causes a non-purulent meningoencephalitis and retinitis in a variety of species. In Lewis rats infected intracerebrally with the highly neurotropic BDV the retina is one of the most severely affected central nervous system (CNS) structures. While BDV-induced damage in the brain has previously been shown to be caused by a T-cell-dependent process, the immunopathological mechanisms leading to BDV-induced retinitis, remain to be elucidated. RNA samples from retinae were subjected to RNase protection assays to detect transcripts of proinflammatory cytokines and chemokines known to be involved in the recruitment of T-cells and macrophages in the CNS. The observed expression profile of proinflammatory cytokines and chemokines, as well as the immunohistochemical detection of αβTCR-positive and CD8-positive T-cells in the BDV-infected retinae, is reminiscent of the situation observed in the brains of Lewis rats during the acute phase of Borna disease. This suggests, that similar immunopathological mechanisms are operating in retinae and brains of infected rats. This research was supported by grants from the Deutsche Forschungsgemeinschaft (J.S.-PA 615/1-1).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1439-0264.2005.00669_112.x
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