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D2–40 Expression in Hemangiomas and Lymphangiomas: Special Reference to its Differential Utility Between Kaposiform Hemangioendothelioma and Acquired Tufted Angioma (2005)

Arai, E. ; Kuramochi, A. ; Shimizu, M. ; [et al.]

Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.

Journal of cutaneous pathology 32 (2005), S. 0

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ISSN: 1600-0560

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Recent investigations have demonstrated the utility of D2–40 as a marker for lymphatic endothelium and can be used for formalin-fixed and paraffin-embedded materials. We studied 13 capillary hemangiomas: kaposiform hemangioendothelioma (KH, 2), acquired tufted angioma (ATA, 5), juvenile hemangioma (JH, 2), granuloma pyogenicum (GP, 4); 6 other hemangiomas: cavernous hemangioma (3), arterio-venous hemangioma (1), angiokeratoma (1), epithelioid hemangioma (1); Kaposi’s sarcoma (1); 12 lymphangiomas: lymphangioma circumscriptum (6), deep type of cutaneous lymphangioma (6). D2–40 monoclonal antibody, endothelial markers (CD31, CD34, Factor VIII related antigen) and juvenile hemangioma-associated marker GLUT-1 were applied. D2–40 was immunopositive for the peripheral area of proliferative capillaries and negative for surrounding dilated vessels in KH, but positive for surrounding dilated vessels and negative for tufted proliferative capillaries in ATA. KH and ATA were all positive for endothelial markers and negative for GLUT-1. Other hemangiomas were negative for D2–40. Eight of 12 cases were positive for lymphangiomas. Based on these results, D2–40 is a useful additional immunostain for the discrimination of KH and ATA. KH and ATA may originate from different stage of both the lymphatic and blood vessel endothelial lineages.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.0303-6987.2005.0320l.x

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Vesiculo-Bullous Dermatomyositis Associated with Malignant Lymphoma (2005)

Ogawa, F. ; Tsuchida, T. ; Arai, E. ; [et al.]

Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.

Journal of cutaneous pathology 32 (2005), S. 0

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ISSN: 1600-0560

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Dermatomyositis is an inflammatory condition of the skin and muscles, and an underlying malignancy is noted in 10% or more of cases. Clinical features of dermatomyositis include increasing general fatigue and proximal (thighs and shoulders) muscle weakness accompanied by erythematous lesions of the skin. There have been several distinct types of dermatomyositis described. Here we describe a case of vesiculo-bullous dermatomyositis, which is a rare variant of dermatomyositis. A 49-year-old woman was admitted to our hospital with a painful erythematous vesicular eruption of the face, trunk and extremities. In addition, edema of the face and fever were observed. Clinically, dermatomyositis was considered because of typical skin rashes (Gottron’s papules, periorbital heliotrope rash and poikiloderma) and serum creatine phosphokinase level of 1,031 IU/L. A skin biopsy was performed. Microscopically, subepidermal vesiculation with marked edema was present. Lymphoplasmacytic infiltration was also observed in the upper dermis. So far only a few case reports of vesiculo-bullous dermatomyositis have been reported in the literature. It should be kept in mind that dermatomyositis may present subepidermal vesiculation in order to avoid a misdiagnosis and unnecessary delayed treatment. Furthermore, an internal malignancy should be considered in such a variant of dermatomyositis.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.0303-6987.2005.320fa.x

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Chronology of Cellular Blue Nevus (2005)

Jin, L. ; Arai, E. ; Tsuchida, T. ; [et al.]

Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.

Journal of cutaneous pathology 32 (2005), S. 0

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ISSN: 1600-0560

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Cellular blue nevus is composed of dendritic melanocytes, together with islands of epithelioid and plump spindle cells. We examined 58 cases of blue nevi. Fourteen cases were common blue nevi. The remaining 44 blue nevi were divided into three types according to its silhouettes. These were nodular (type 1, 18 cases), nodular with notch (type 2, 16 cases), and rounded pushing patterns (type 3, 10 cases). Well circumscribed top heavy nodule was observed in type 1, and it was limited to the dermis. Type 2 showed budding appearance into the subcutaneous tissue. Type 3 revealed bottom heavy with downward pushing margin. Both type 2 and type 3 were demonstrated biphasic patterns of epithelioid and spindle cells. Perineural distribution of melanocytes was also observed in type 2 and 3. The size of these types was 3.3 mm in type 1, 4.7 mm in type 2, and 7.4 mm in type 3. The thickness of these types was 1.6 mm in type 1, 2.5 mm in type 2, and 5.2 mm in type 3. Our results suggest that cellular blue nevi may be divided into three stages. Type 1 is its early stage, and may be misinterpreted as common blue nevi.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.0303-6987.2005.320di.x

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Human papillomaviruses of the mucosal type are present in some cases of extragenital Bowen's disease (2005)

Zheng, S. ; Adachi, A. ; Shimizu, M. ; [et al.]

Oxford, UK : Blackwell Science Ltd

British journal of dermatology 152 (2005), S. 0

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ISSN: 1365-2133

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Background Bowen's disease in the genital area is generally considered to be caused by mucosal high-risk human papillomaviruses (HPVs). However, the detection rate and spectrum of HPVs in extragenital Bowen's disease are various and it is not clear to what extent HPV is involved in its pathogenesis.Objectives To assess the degree of association of HPV in extragenital cases by examining detection rates, types, quantities and localization of HPV.Methods A polymerase chain reaction (PCR) approach that we had previously established, which can give sensitive detection of a broad range of HPVs from cutaneous [including epidermodysplasia verruciformis-related HPVs (EV-HPVs)] to mucosal HPVs, was applied to samples from 41 patients with extragenital Bowen's disease and normal skin samples from 48 individuals. Semiquantitative L1-PCR and tyramide-based in situ hybridization (ISH) were also employed for positive cases.Results HPVs belonging to the mucosal high-risk group were detected in three patients with Bowen's disease (7%; two HPV 16 and one HPV 33), with 101−103 copy equivalents per diploid amount of cellular DNA. They were distributed among most nuclei of tumour cells but in none of the cells of adjacent normal skin. HPVs belonging to the cutaneous group were detected in two patients (5%; HPV 27 and HPV 76) at 10−2−10−3 copy equivalents, the same level as in a normal skin specimen positive for type 23 EV-HPV. No positive signals were observed by ISH.Conclusions HPVs belonging to the mucosal high-risk group may participate in the development of extragenital Bowen's disease.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06643.x

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Clinicopathological and Immunohistochemical Study of Eccrine Porocarcinoma (Malignant Eccrine Poroma) (2005)

Ogawa, F. ; Arai, E. ; Tsuchida, T. ; [et al.]

Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.

Journal of cutaneous pathology 32 (2005), S. 0

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ISSN: 1600-0560

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Porocarcinomas are thought to be differentiated into the acrosyringeal portion of the sweat duct, and they are relatively rare. It may develop from a long standing eccrine poroma undergoing malignant transformation or may arise de novo. We evaluated pathological and immunohistocheimical findings of six cases of eccrine porocarcinoma. Special stains (PAS and PAS with diastase) and immunohistochemical stainings (CEA, CAM5.2, CK7, bcl-2, p53 protein, and MIB-1) were performed. We observed asymmetrical architecture, cytological pleomorphism, prominent nucleoli, ductal differentiation, intracytoplasmic lumina, mitotic activity, and melanin colonization. Three patients were male and four patients were female. The average age was 76 years. The time interval from tumor onset to treatment ranged from 6 months to 10 years. The mean size was 3.2 cm, and the mean depth of invasion was 1.0 cm. Four tumors were found on the head, one on the hip, and one on the foot. Regional lymph node metastases were noted in one case. Microscopically, luminal spaces and intracytoplasmic lumina were noted in all cases. Immunohistochemically, the mean MIB-1 index was 41%. P53 immunoreactivity was detected in five cases. Interestingly, a case of porocarcinoma with lymph node metastases showed high mitotic figures as well as less lymphocytic infiltration.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.0303-6987.2005.320fb.x

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Lymphoepithelioma-Like Carcinoma of the Skin: A Case Report (2005)

Mitsuhashi, T. ; Tsuchida, T. ; Arai, E. ; [et al.]

Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.

Journal of cutaneous pathology 32 (2005), S. 0

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ISSN: 1600-0560

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Lymphoepithelioma-like carcinoma of the skin is a rare tumor with a microscopic resemblance to lymphoepitheliomatous carcinoma of the nasopharynx. We present a 93-year-old man with papules on the left auricle to the cheek that were gradually enlarged. By the time of a biopsy, it grew to a 5.0 × 3.0 × 2.8 cm dark red mass, and necrotic debris was attached to the surface. Histologically, a relatively well-demarcated, dermal-hypodermic multiple lobules were composed of irregular islands of atypical epithelial cells. The uniform tumor cells had moderate amounts of lightly eosinophilic cytoplasm and vesicular nuclei with one or two prominent nucleoli. A dense lymphocytic infiltrate was present within the neoplastic islands, obscuring the epithelial component. The neoplastic cells were unconnected to the overlying epidermis. Neither squamous nor glandular differentiation was present. Immunohistochemically, the neoplastic cells were positive for epithelial membrane antigen and cytokeratin, and negative for latent membrane protein 1. No Epstein-Barr virus-encoded RNA (EBER) was detected by in situ hybridization. The negativity for Epstein-Barr virus may be a help in the differential diagnosis from metastatic undifferentiated nasopharyngeal carcinoma, which is uniformly positive for EBER.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.0303-6987.2005.320ev.x

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