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  • 2005-2009  (37)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Hypoxic Pulmonary Hypertension (HPH) and Iptakalim, a Novel ATP-sensitive Potassium Channel Opener Targeting Smaller Arteries in Hypertension (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Cardiovascular drug reviews 23 (2005), S. 0 
    Details
    ISSN: 1527-3466
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Hypoxic pulmonary hypertension (HPH) is a serious and potentially devastating chronic disorder of the pulmonary circulation. Attempts to use drugs in the therapy of hypoxic pulmonary hypertension indicated the importance of prevention or reduction of vasoconstriction as well as of the reversal of remodeling within the cardiovascular system. Iptakalim (2,3-dimethyl-N-(1-methylethyl)-2-butylamine), a novel ATP-sensitive potassium channel opener, has the desired effects on hypoxic pulmonary arteries. Iptakalim decreases the elevated mean pressure in pulmonary arteries, and attenuates remodeling in the right ventricle, pulmonary arteries and airways. Moreover, iptakalim has selective antihypertensive effects: it significantly lowers arterial pressure in hypertensive animals, but has little if any effect in normotensive animals. In HPH iptakalim has selective effects on smaller arteries. Long-term iptakalim therapy decreases expression of sulfonylurea receptor 2 and of mRNA of inwardly rectifying potassium channel in smaller arteries of spontaneously hypertensive rats. Iptakalim inhibits the effects of endothelin-1, reduces the intracellular calcium concentration and inhibits the cell cycle in smooth muscle cells of pulmonary arteries. There is no evidence for the development of tolerance to the long-lasting antihypertensive action of iptakalim. At therapeutic doses iptakalim has no effects on the central nervous, respiratory, digestive, or endocrine systems. It has a broad therapeutic range, so that it can be safely used in the therapy of HPH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1527-3466.2005.tb00174.x
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  • 2
    Electronic Resource
    Electronic Resource
    RAPID AND EFFICIENT GENERATION OF PCR TEMPLATES FROM ESCHERICHIA COLI, SACCHAROMYCES CEREVISIAE AND ORYZA SATIVA USING A MICROWAVE AND BY BOILING (2005)
    Oxford, UK : Blackwell Science Inc
    Journal of rapid methods and automation in microbiology 13 (2005), S. 0 
    Details
    ISSN: 1745-4581
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Simple methods for the preparation of polymerase chain reaction (PCR) templates from Escherichia coli, Saccharomyces cerevisiae and Oryza sativa using a microwave and by boiling are described without the need for any special chemical reagent such as a detergent. The microwave and boiling methods were robust for the preparation of both plasmid and genomic templates of E. coli, as was the boiling approach for S. cerevisiae DNA. The microwave procedure was only suitable for dry yeast colonies with fair efficiency as absence of water (H2O) was critical for a successful PCR. Oryza sativa genomic DNA was amplified with both approaches with satisfactory efficiency. Escherichia coli plasmids can be prepared using a microwave with a yield equivalent to 15–20% of an alkaline lysis mini-prep. PCR templates were also efficiently generated from Pichia pastoris and Ganoderma lucidum by using the boiling method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-4581.2005.00003.x
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  • 3
    Electronic Resource
    Electronic Resource
    THE MAGIC BULLETS AND TUBERCULOSIS DRUG TARGETS (2005)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 45 (2005), S. 529-564 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Notes: Modern chemotherapy has played a major role in our control of tuberculosis. Yet tuberculosis still remains a leading infectious disease worldwide, largely owing to persistence of tubercle bacillus and inadequacy of the current chemotherapy. The increasing emergence of drug-resistant tuberculosis along with the HIV pandemic threatens disease control and highlights both the need to understand how our current drugs work and the need to develop new and more effective drugs. This review provides a brief historical account of tuberculosis drugs, examines the problem of current chemotherapy, discusses the targets of current tuberculosis drugs, focuses on some promising new drug candidates, and proposes a range of novel drug targets for intervention. Finally, this review addresses the problem of conventional drug screens based on inhibition of replicating bacilli and the challenge to develop drugs that target nonreplicating persistent bacilli. A new generation of drugs that target persistent bacilli is needed for more effective treatment of tuberculosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pharmtox.45.120403.100120
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  • 4
    Electronic Resource
    Electronic Resource
    Sustainable design in its simplest form: Lessons from the living villages of Fujian rammed earth houses (2005)
    Bingley : Emerald
    Structural survey 23 (2005), S. 371-385 
    Details
    ISSN: 0263-080X
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Architecture, Civil Engineering, Surveying
    Notes: Purpose - The aims of the study are to analyze the features of a socially self-contained society; to analyze the features of an environmentally sustainable society; and to generate a discussion on an indigenous approach towards the sustainable design of communities, particularly through the study of the round village for its unique form and performance in terms of sustainable construction. Design/methodology/approach - Researchers from an international group undertook a field study of a number of specimen round and square shape Hakka villages in December 2004. They discussed their preliminary findings with local academics regarding significant attributes for sustainable design principles, and summarized lessons by means of spatial and construction studies that inform contemporary urban designers' knowledge and practice of sustainability through indigenous architecture. Findings - Through reinterpretation of Feng-shui theory, various observations made were easily and naturally correlated to basic laws of sustainability. The biggest message that comes from Fujian round architecture is that a genuine practitioner of environmental and social sustainability relies on a simplicity of approach - a respect for nature. Research limitations/implications - The study is confined primarily to observations by a team of architects and engineers. Practical implications - Field study of vernacular architecture provides useful information and first-hand data for researchers on rammed earth structures. Originality/value - The study of rammed earth structures in remote areas of China, in both coastal and earthquake active zones, offers fresh insight into the integrity and ingenuity of early settlers in sustainable construction. The research provides preliminary findings regarding environmental and construction practice in age-old Hakka round houses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/02630800510635119
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2 (2007)
    [s.l.] : Nature Publishing Group
    Nature medicine 13 (2007), S. 486-491 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] MicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, that mediate post-transcriptional gene silencing by annealing to inexactly complementary sequences in the 3′-untranslated regions of target mRNAs. Our current understanding of the functions of miRNAs relies ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm1569
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    V1 spinal neurons regulate the speed of vertebrate locomotor outputs (2006)
    [s.l.] : Nature Publishing Group
    Nature 440 (2006), S. 215-219 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The neuronal networks that generate vertebrate movements such as walking and swimming are embedded in the spinal cord. These networks, which are referred to as central pattern generators (CPGs), are ideal systems for determining how ensembles of neurons generate simple behavioural outputs. In ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature04545
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  • 7
    Electronic Resource
    Electronic Resource
    Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis (2005)
    [s.l.] : Nature Publishing Group
    Nature 438 (2005), S. 981-987 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Tamoxifen, a selective oestrogen receptor modulator, has been used in the treatment of all stages of hormone-responsive breast cancer. However, tamoxifen shows partial oestrogenic activity in the uterus and its use has been associated with an increased incidence of endometrial cancer. The molecular ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature04225
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  • 8
    Electronic Resource
    Electronic Resource
    Biodesulfurization of dibenzothiophene and other organic sulfur compounds by a newly isolated Microbacterium strain ZD-M2 (2005)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 247 (2005), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: A new bacterial strain capable of selectively desulfurizing dibenzothiphene (DBT) was isolated from sludge. This organism, designated ZD-M2, clustered most closely with members of the genus Microbacterium, as determined by 16S rRNA gene sequence analysis. Metabolites produced by DBT desulfurization were identified by GC-MS, and two sulfur-free products, 2-methoxybiphenyl (2-MBP) and biphenyl, were detected in addition to 2-hydroxybiphenyl (2-HBP). This strain can also totally degrade 4,6-dimethyl-DBT, thiophene, benzothiophene and 70% diphenylsulfide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/j.femsle.2005.04.025
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  • 9
    Electronic Resource
    Electronic Resource
    Effects of Electrical Characters on Electrical Fatigue Behavior in PLZT Ferroelectric Ceramics (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 280-283 (Feb. 2007), p. 159-162 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Electrical fatigue tests have been conducted on PLZT ferroelectric ceramics. It was found that the higher the applied electrical field magnitude, the faster the Pr decreases; the samples under the same electrical field magnitude but with square wave have higher fatigue rate than that of sine wave. It was observed that at low frequency of applied field (50Hz and 500Hz), the polarization decreased very quickly and dropped below 70% of the original value within 106.2 switching cycles, however, when fatigue test were conducted at high frequencies of 100kHz and 300kHz, the polarization did not change significantly even after 109 cycles. The SEM analysis indicated that the facture mode was mainly of trans-granular forthe virgin non-fatigued sample, while of inter-granular for the fatigue sample. The quantitative information on the 90° domain switching was measured in situ using X-ray diffraction. The effects of electrical characters on electrical fatigue behavior were explained according to the mechanism of electrical fatigue in PLZT ferroelectric ceramics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/48/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.280-283.159.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    The Progress of the Research and Application of Ion Implantation Biotechnology in China (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 107 (Oct. 2005), p. 37-42 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: This paper summarizes the development of the research and application of ion implantation biotechnology on plant, animal and microorganism varieties Improvement, and it also includes the contemporary effects and utilization of ion implantation, and the application of ion implantation on trans-gene plant.In 1980s, cooperated with Anhui Academy of Agriculture Sciences, the ion implantation was applied for crops’ improvement by Plasma Physics Research Institute of the Chinese Academy of Sciences, and made greater progress in both practice and theory, which attracted many scholars inside and outside. By using ion implantation, extensive researches had been made in different materials including plant, animal and microorganism on different levels. With combination of physics and biology, as a new cross subject and a unique technology system, the ion implantation biotechnology came into being, and created more dramatically economic and social benefit in crops improvement by transferring exogenous gene. This paper summarizes the development of the research and application of ion implantation biotechnology
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/21/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.107.37.pdf
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