ISSN:
1439-0426
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
Notes:
The pharmacokinetic properties of cephalexin were studied in sea bream (mean weight 77 g), Sparus aurata (L.) after a single intraperitoneal injection (200 mg kg−1). Pharmacokinetic analysis of the serum concentrations vs time points obtained was performed using non-compartmental analysis and a compartmental pharmacokinetic model approach. In the latter case, a two-compartment open model with a lag time gave the best fitting. The maximum peak serum concentration was 5.018 mg ml−1 kg−1 1 h post-treatment. The area under the curve (AUC) cephalexin was 17.394 mg·h kg−1 and the elimination half-life of 1.83 h.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1439-0426.2004.00578.x
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