ISSN:
1365-2036
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
Serotonin and its type-4 (5-hydroxytryptamine4) receptor play a major role in the physiology of the gastrointestinal tract. The effect of intravenous and/or oral tegaserod, a 5-hydroxytryptamine4 receptor partial agonist, on gastric emptying, small bowel transit and colonic transit has not been studied in detail in humans.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:To assess the pharmacodynamic effects of repeated oral and intravenous administration of tegaserod on gastric emptying and small intestine and colonic transit.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:A randomized, placebo-controlled, double-blind, three-way, crossover study of 6 mg oral and 0.6 mg intravenous tegaserod in 12 healthy male subjects was performed. Each treatment arm of the study involved 3 days of twice-daily administration and 1 day of daily administration of the study drugs.〈section xml:id="abs1-4"〉〈title type="main"〉Results:In comparison with placebo, oral and intravenous tegaserod significantly increased the gastric emptying rate (P 〈 0.01), accelerated colonic filling (P 〈 0.01) and shortened colonic transit at 48 h (P 〈 0.05). Tegaserod shortened the small intestine transit time by 30% after oral and by 37% after intravenous administration.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:In healthy subjects, tegaserod markedly accelerated gastric emptying and small intestinal transit, and induced a small but significant acceleration of colonic transit. Tegaserod can act as a promotile agent throughout the gastrointestinal tract.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1046/j.1365-2036.2001.01103.x
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