ISSN:
1364-6753
Schlagwort(e):
Key words Partial seizure
;
Epilepsy
;
10q
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
ABSTRACT A four-generation family with nine individuals with temporal partial epilepsy was studied. Detailed epilepsy history was investigated by structured interview. All putatively affected family members underwent a standardized electroencephalographic examination. The phenotype in the family was characterized by a short acoustic aura followed by rapid secondary generalization. To examine if the trait is linked to a region on 10q (interval D10S185–D10S1671), which has been reported in two other epilepsy families with similar phenotypes, linkage analysis was performed using nine markers covering the previously reported region. A maximum two-point LOD score of 2.1 at a recombination fraction of zero was obtained. All living affected individuals shared the same haplotype, while three unaffected at-risk adults did not. This result presents supporting evidence of a gene for partial epilepsy on 10q.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/s100480000091
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