ISSN:
1440-1797
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
We compared an antiproteinuric effect of a lipid-lowering agent probucol on two distinct types of experimental nephrosis in rats, i.e. mercuric–chloride (HgCl2)-induced autoimmune glomerulonephritis in Brown Norway (BN) rats and puromycin aminonucleoside (PA)-nephrosis in Wistar rats. The rats were fed either standard rat chow or chow containing 5% probucol. BN rats were treated with HgCl2 according to a standard protocol (HgCl2 1 mg/kg subcutaneously three times/week). Probucol treatment did not ameliorate proteinuria, renal histology or a strong linear staining for IgG and an intercellular adhesion molecule, ICAM-1, in glomeruli. Wistar rats were made nephrotic with an intraperitoneal injection of PA (100 mg/kg). In this model, in contrast to the BN rat model, no glomerular deposition of IgG or ICAM-1 was observed. Probucol treatment ameliorated proteinuria significantly. These findings suggest that the response to probucol differs in different experimental nephrosis models. As probucol only affects PA-nephrosis, in which ICAM-1 expression is negative, the ICAM-1 attenuation is not likely to be involved in the antiproteinuric effect of probucol.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1046/j.1440-1797.2000.00012.x
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