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  • 1
    Digitale Medien
    Digitale Medien
    Body Dysmorphic Disorder: A Review of the Current Knowledge (2000)
    Oxford, UK and Boston, USA : Blackwell Publishing Ltd
    Child and adolescent mental health 5 (2000), S. 0 
    Details
    ISSN: 1475-3588
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Psychologie
    Notizen: Body Dysmorphic Disorder (BDD) is an excessive preoccupation with an imagined, or real, slight defect in normal physical appearance. The disorder, which usually begins during adolescence, tends to be chronic, and probably is much more common than is usually thought. This review presents an overview of the available scientific literature of BDD. It provides information about historical aspects, epidemiology, clinical features, aetiology, and instruments for assessing BDD. The relationship of BDD with other psychiatric disorders such as depression, obsessive-compulsive disorders, anxiety disorders, schizophrenia, eating disorders and personality disorders is discussed. Aetiological theories, including psychological and neurobiological explanations, are reviewed. Finally, psychopharmacological and psychotherapeutic treatment approaches are presented with special regard to treatment with serotonin-reuptake inhibitors, behavioural therapy and cognitive-behavioural therapy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/1475-3588.00280
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  • 2
    Digitale Medien
    Digitale Medien
    Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor (2004)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 91 (2004), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: G-protein-coupled receptors (GPCRs) are the largest group of cell surface molecules involved in signal transduction and are receptors for a wide variety of stimuli ranging from light, calcium and odourants to biogenic amines and peptides. It is assumed that systematic genomic data-mining has identified the overwhelming majority of all remaining GPCRs in the genome. Here we report the cloning of a novel orphan GPCR which was identified in a search for erythropoietin-induced genes in the brain as a strongly up-regulated gene. This unknown gene coded for a protein which had a seven-transmembrane topology and key features typical of GPCRs of the A family but a low overall identity to all known GPCRs. The protein, coded ee3, has an unusually high evolutionary conservation and is expressed in neurons in diverse areas of the CNS with relation to integrative functions or motor tasks. A yeast two-hybrid screen for interacting proteins revealed binding to the microtubule-associated protein (MAP) 1b. Coupling to MAP1a has been described for another cognate GPCR, the 5-hydroxytryptamine (5HT) 2a receptor. Surprisingly, we found complete colocalization of ee3 and the 5HT2a receptor. The interaction with MAP1b proved to be critical for the stability or folding of ee3 as in mice lacking MAP1b the ee3 protein was undetectable by immunohistochemistry, although messenger RNA levels remained unchanged. We propose that ee3 is a highly interesting new orphan GPCR with potential connections to erythropoietin and 5HT2a receptor signalling.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.2004.02799.x
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  • 3
    Digitale Medien
    Digitale Medien
    Gold nanoparticle single-electron transistor with carbon nanotube leads (2001)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 79 (2001), S. 2106-2108 
    Details
    ISSN: 1077-3118
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: We have used carbon nanotubes to electrically contact a 7 nm gold particle by scanning-probe manipulation. The result was a single-electron transistor showing a periodic modulation of the current as a function of gate voltage for temperatures up to ∼200 K, with the particle responsible for the main features of the electron transport. This interpretation could be verified when the particle was removed and the two nanotubes were moved into electrical contact. © 2001 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1405154
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  • 4
    Digitale Medien
    Digitale Medien
    Nanoscale tungsten aerosol particles embedded in GaAs (2002)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 80 (2002), S. 2976-2978 
    Details
    ISSN: 1077-3118
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: GaAs containing buried nanoscale tungsten particles has been characterized electrically. The particles were produced using a special aerosol process and were embedded in GaAs by epitaxial overgrowth. Two different particle sizes were investigated separately. When the particle concentration was increased, a conductance drop of about 500 times was observed. A simulation model, based on a random distribution of the particles, was developed and used to support our findings. The major advantage of our method is the simplicity and low processing cost. © 2002 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1470701
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  • 5
    Digitale Medien
    Digitale Medien
    Approximate solution for solute transport during spherical-flow push-pull tests (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Ground water 43 (2005), S. 0 
    Details
    ISSN: 1745-6584
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Energietechnik , Geologie und Paläontologie
    Notizen: An approximate analytical solution to the advection-dispersion equation was derived to describe solute transport during spherical-flow conditions in single-well push-pull tests. The spherical-flow case may be applicable to aquifer tests conducted in packed intervals or partially penetrating wells. Using results of two-dimensional numerical simulations, we briefly illustrate the applicability of the derived spherical-flow solution and provide a comparison with its cylindrical-flow counterpart. Good agreement between simulated extraction-phase breakthrough curves and the spherical-flow solution was found when the length of the injection/extraction region was small compared to both aquifer thickness and maximum solute frontal position at the end of the injection phase. On the other hand, discrepancies between simulated breakthrough curves and the spherical-flow solution increased with increasing anisotropy in hydraulic conductivities. Several inherent limitations embedded in its derivation such as assumptions of isotropy and homogeneity warrant the cautious use of the spherical-flow solution.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1745-6584.2005.0002.x
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  • 6
    Digitale Medien
    Digitale Medien
    PATHOPHYSIOLOGICAL-BASED APPROACHES TO TREATMENT OF SICKLE CELL DISEASE (2003)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 54 (2003), S. 89-112 
    Details
    ISSN: 0066-4219
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Medizin
    Notizen: Abstract Sickle hemoglobin (HbS), as a result of its polymer-related and oxidant effects, damages the sickle erythrocyte, provokes inflammation, and causes endothelial injury. All these elements cause the phenotype of sickle cell disease. Novel treatments inhibit HbS polymerization by inducing fetal hemoglobin expression, prevent or repair erythrocyte dehydration by slowing cellular potassium and water loss, and replace HbS-producing erythroid progenitors by stem cell transplantation. Future treatment prospects include gene therapy, interruption of the interaction of sickle cells with the endothelium, inhibition of oxidative damage, and protection of an injured endothelium.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.med.54.101601.152439
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  • 7
    Digitale Medien
    Digitale Medien
    Simulation of material properties below the Debye temperature: A path-integral molecular dynamics case study of quartz (2001)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 114 (2001), S. 6364-6370 
    Details
    ISSN: 1089-7690
    Quelle: AIP Digital Archive
    Thema: Physik , Chemie und Pharmazie
    Notizen: Classical and path integral molecular dynamics (PIMD) simulations are used to study α and β quartz in a large range of temperatures at zero external stress. PIMD account for quantum fluctuations of atomic vibrations, which can modify material properties at temperatures below the Debye temperature. The difference between classical and quantum mechanical results for bond lengths, bond angles, elastic moduli, and some dynamical properties is calculated and comparison to experimental data is done. Only quantum mechanical simulations are able to reproduce the correct thermomechanical properties below room temperature. It is discussed in how far classical and PIMD simulations can be helpful in constructing improved potential energy surfaces for silica. © 2001 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1355772
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  • 8
    Digitale Medien
    Digitale Medien
    A Monte Carlo simulation for the stripping of the (square root of)3×(square root of)3 R30° alkanethiol lattice from Au(111) terraces and steps (2002)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 117 (2002), S. 2293-2298 
    Details
    ISSN: 1089-7690
    Quelle: AIP Digital Archive
    Thema: Physik , Chemie und Pharmazie
    Notizen: Monte Carlo simulations of a model for the stripping of (square root of)3×(square root of)3 R30° alkanethiol lattices from terraces and steps of a (111) metal face in aqueous solutions are presented. In the model the stripping probability of an adsorbed alkanethiolate molecule depends on the applied potential, on intermolecular forces that stabilize the alkanethiol layer, and on the presence of substrate defects. Stabilizing intermolecular forces are also responsible for alkanethiolate aggregate formation during the stripping process. Snapshots and voltammograms derived from the model reproduce experimental STM images and electrochemical data for alkanethiol stripping from the Au(111) surface. © 2002 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1490922
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  • 9
    Digitale Medien
    Digitale Medien
    Following transformation in self-assembled alkanethiol monolayers on Au(111) by in situ scanning tunneling microscopy (2001)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 115 (2001), S. 6672-6678 
    Details
    ISSN: 1089-7690
    Quelle: AIP Digital Archive
    Thema: Physik , Chemie und Pharmazie
    Notizen: Transformations taking place in alkanethiol adlayers on Au(111) in contact with an electrolyte solution in the potential range −1.1 V〈E〈−0.4 V have been investigated by in situ scanning tunneling microscopy (STM). Two different types of processes have been identified: potential-dependent transformations involving electrodesorption/electroadsorption of molecules, and structure and defect fluctuations that take place without the influence of the electric potential. Potential-dependent transformations involve two steps: electrodesorption of chemisorbed alkanethiol molecules from Au(111) terraces producing unstable physisorbed aggregates of alkanethiolates, and electrodesorption of alkanethiol molecules that remained chemisorbed at step edges due to the increased coordination number at these substrate sites. © 2001 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1403000
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  • 10
    Digitale Medien
    Digitale Medien
    On quantum effects near the liquid–vapor transition in helium (2002)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 116 (2002), S. 1621-1628 
    Details
    ISSN: 1089-7690
    Quelle: AIP Digital Archive
    Thema: Physik , Chemie und Pharmazie
    Notizen: The liquid–vapor transition in 3He and 4He is investigated by means of path-integral molecular dynamics and the quantum virial expansion. Both methods are applied to the critical isobar and the critical isochore. While previous path-integral simulations have mainly considered the lambda transition and superfluid regime in 4He, we focus on the vicinity of the critical point and obtain good agreement with experimental results for the molar volume and the internal energy down to subcritical temperatures. We find that an effective classical potential that properly describes the two-particle radial distribution function exhibits a strong temperature dependence near the critical temperature. This contrasts with the behavior of essentially classical systems like xenon, where the effective potential is independent of temperature. It is conjectured that, owing to this difference in behavior between classical and quantum-mechanical systems, the crossover behavior observed for helium in the vicinity of the critical point differs qualitatively from that of other simple liquids. © 2002 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1429957
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