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  • 1
    Digitale Medien
    Digitale Medien
    FETAL GROWTH RETARDATION AND THE MATERNAL ARTERIAL SUPPLY OF THE HUMAN PLACENTA IN THE ABSENCE OF SUSTAINED HYPERTENSION (1980)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 87 (1980), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: In five patients with fetal growth retardation in pregnancies with no or only a moderate and transient rise in blood pressure, vascular lesions in the placental bed spiral arteries were found. These lesions are characterized by less well developed physiological morphological changes, by extensive intimal thickening, by fibrinoid degeneration of the media and by acute atherosis. The recurrent fetal growth retardation in these pregnancies may be the first clinical manifestation of underlying reno-vascular disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1980.tb04601.x
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  • 2
    Digitale Medien
    Digitale Medien
    Design of surface forces apparatus for tribology studies combined with nonlinear optical spectroscopy (1997)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 68 (1997), S. 2499-2504 
    Details
    ISSN: 1089-7623
    Quelle: AIP Digital Archive
    Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: We describe the design, calibration, and performance of surface forces apparatus with the capability of illumination of the contact interface for spectroscopic investigation using optical techniques. The apparatus can be placed in the path of a Nd-YAG laser for studies of the linear response or the second harmonic and sum-frequency generation from a material confined between the two surfaces. In addition to the standard fringes of equal chromatic order technique, which we have digitized for accurate and fast analysis, the distance of separation can be measured with a fiber-optic interferometer during spectroscopic measurements (2 Å resolution and 10 ms response time). The sample approach is accomplished through application of a motor drive, piezoelectric actuator, or electromagnetic lever deflection for variable degrees of range, sensitivity, and response time. To demonstrate the operation of the instrument, the stepwise expulsion of discrete layers of octamethylcyclotetrasiloxane from the contact is shown. Lateral forces may also be studied by using piezoelectric bimorphs to induce and direct the motion of one surface. © 1997 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1148148
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  • 3
    Digitale Medien
    Digitale Medien
    Multiple idiopathic mucocutaneous neuromas: a new entity? (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 145 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We report a 53-year-old woman who presented with multiple painful red cutaneous papules that had been growing slowly for 13 years. Histopathology showed typical features of neuroma. Biological, morphological and genetic investigations were negative and excluded the diagnosis of multiple endocrine neoplasia type 2b. After reviewing the literature, we concluded that our patient has an extremely unusual acquired disease, which must be considered as a distinct entity in the spectrum of cutaneous neurological disorders.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04479.x
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  • 4
    Digitale Medien
    Digitale Medien
    Hereditary ‘white nails’: a genetic and structural study (2004)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 151 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background  Hereditary subtotal leuconychia is a rare nail disease. The gene(s) underlying this phenotype is (are) not known. Immunohistochemical and ultrastructural studies of nails are performed infrequently.Objectives  To perform genetic linkage analysis and to assess ultrastructure and soft/hard keratin expression in hereditary white nails.Methods  We have analysed microscopically and ultrastructurally the white nails of a patient from a family in which the trait is inherited in an autosomal dominant manner as an isolated symptom. No skin lesions or hair abnormalities could be detected. Genetic linkage studies were performed on DNA samples obtained from several members of the affected family. A longitudinal surgical biopsy of the nail from a great toe was split in two parts. One part was fixed in formalin and processed for histopathology. Another part was further subdivided and embedded either in Epon, following fixation in 2% glutaraldehyde, or in Lowicryl K4M, after fixation in 3% paraformaldehyde. Dewaxed nail sections and Lowicryl ultrathin sections were also stained with various antikeratin antibodies.Results  Genetic linkage studies of the family pointed to the disease gene mapping to the chromosomal 12q13 region. Genes mapping within this chromosomal region include the genes coding for type II (basic) cytokeratins and hard keratins. The nail matrix presented an abnormal hypergranulosis. The upper part of the nail plate, originating from the proximal nail matrix, had a nonhomogeneous lamellar appearance, with numerous intracellular ‘lipidic’ vacuoles and ‘empty’ spaces separating keratin filament bundles. These cells were progressively shed at the nail surface. The cell loss was compensated by hyperproliferation of the distal matrix and of the nail bed keratinocytes, with persistent marked parakeratosis and loose arrangement of keratin bundles. The distal matrix and the nail bed contributed equally to formation of the lower plate. This presented the characteristics of a tissue composed of soft keratins. Accordingly, there was virtually no labelling with the Hb1 antibody to a basic hard keratin in the white nail, whereas the labelling with AE3 antibody to all type II keratins and with KL1 recognizing suprabasal soft keratins was normal or even enhanced.Conclusions  Genetic linkage indicates that the gene defect underlying the leuconychia in the family studied resides on chromosome 12q13. As the type II keratins map within this chromosomal interval, it is possible that a mutation in one of these keratin genes may be a cause of the hereditary leuconychia. The white appearance of nails in this disease seems to be due to an abnormal keratinization of cells originating from the proximal nail matrix, leading to the presence of abundant intracellular vacuoles and to a lesser compactness of keratins.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.2004.05994.x
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  • 5
    Digitale Medien
    Digitale Medien
    Three New Polymorphic Forms of Molybdenum Pentachloride (1997)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 53 (1997), S. 895-903 
    Details
    ISSN: 1600-5740
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik
    Notizen: Three new polymorphic modifications of molybdenum pentachloride could be obtained by solvothermal syntheses in CCl4 and SbCl5 as solvents. The structures have been solved by single-crystal X-ray diffraction. The already known structure of monoclinic \alpha-MoCl5 (C2/m) is not isomorphous with \alpha-NbCl5 and is better derived from the closest packing of Cl atoms of the Sm type with molybdenum occupying 1/5 of the octahedral holes. The triclinic structure of \beta-MoCl5 (P\overline 1) can be derived from hexagonal closest packing. The orthorhombic structure of \gamma-MoCl5 (Pnma) and the monoclinic structure of \delta-MoCl5 (P21/c) can both be derived from double-hexagonal closest packing. All four forms of MoCl5 have in common the discrete Mo2Cl10 moieties built from edge-sharing double octahedra with the metal atoms displaced from the octahedron centres away from each other. The differences between the modifications lie in the different stacking sequences of the close-packed Cl-atom layers and the different occupation of the octahedral interstices. This is reflected in the group–subgroup relationships of the space groups of the closest packings and the molybdenum pentachlorides. X-ray powder diffraction shows that sublimed MoCl5 is a mixture of all four modifications in variable amounts and probably a further unknown form.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1107/S0108768197008331
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  • 6
    Digitale Medien
    Digitale Medien
    Spontaneous pinwheel annihilation during visual development (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 395 (1998), S. 73-78 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Neurons in the visual cortex respond preferentially to edge-like stimuli of a particular orientation. It is a long-standing hypothesis that orientation selectivity arises during development through the activity-dependent refinement of cortical circuitry. Unambiguous evidence for such a process ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/25736
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  • 7
    Digitale Medien
    Digitale Medien
    Organization of the visual cortex (1996)
    [s.l.] : Nature Publishing Group
    Nature 382 (1996), S. 306-306 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] SIR - One long-standing question in developmental neuroscience is whether the functional architecture of the visual cortex is epigenetically induced by activity-dependent mechanisms or whether it is prespecified by genetic instructions1'2. It is widely assumed that dependence on experience and ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/382306a0
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  • 8
    Digitale Medien
    Digitale Medien
    Simvastatin reduces activation of normal platelets by LDL isolated from patients with familial hypercholesterolaemia and familial defective apolipoprotein B (1997)
    Springer
    European journal of clinical pharmacology 53 (1997), S. 277-279 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Key words Platelet aggregation simvastatin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002280050377
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  • 9
    Digitale Medien
    Digitale Medien
    Anticardiolipin antibodies do not seem to be associated with APC resistance in vivo or in vitro (1995)
    Springer
    Annals of hematology 71 (1995), S. 195-198 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Anticardiolipin antibodies ; Lupus anticoagulants ; APC resistance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Anticardiolipin antibodies (aCL) or lupus anticoagulants (LA) have been found to exert an inhibitory action upon the activation and function of protein C, a natural coagulation inhibitor. Recently an in vitro phenomenon called resistance to activated protein C (APC resistance) has been described as the most frequent cause of hereditary thrombophilia. In order to see whether a positive association of APC resistance with aCL exists we examined plasma of 162 consecutive outpatients referred for thrombophilia screening. Further, the IgG fraction was isolated from plasma of two aCL-positive and LA-negative patients and of two aCL-negative healthy subjects by means of protein A affinity chromatography. Each of these isolates was mixed with normal plasma, and the APC resistance was assayed; 25/162 (15.4%) patients had confirmed abnormal APC resistance. Only 1/25 (4.0%) APC resistance-positive patients and 11/137 (8.0%) APC resistance-negative patients had positive IgG- and/or IgM-aCL (p=0.5, nonsignificant). In the in vitro test system the APC resistance ratio remained unaffected after addition of normal IgG or aCL-IgG fraction in the tested normal plasma and did not deviate from the range of buffer controls. These data do not suggest any association of aCL with abnormal APC resistance. aCL-IgG fractions from aCL-positive and LA-negative plasmas do not interfere with the APC resistance test system in vitro in low concentration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01910318
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  • 10
    Digitale Medien
    Digitale Medien
    Anticardiolipin antibodies do not seem to be associated with APC resistance in vivo or in vitro (1995)
    Springer
    Annals of hematology 71 (1995), S. 195-198 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Key words Anticardiolipin antibodies ; Lupus anticoagulants ; APC resistance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Anticardiolipin antibodies (aCL) or lupus anticoagulants (LA) have been found to exert an inhibitory action upon the activation and function of protein C, a natural coagulation inhibitor. Recently an in vitro phenomenon called resistance to activated protein C (APC resistance) has been described as the most frequent cause of hereditary thrombophilia. In order to see whether a positive association of APC resistance with aCL exists we examined plasma of 162 consecutive outpatients referred for thrombophilia screening. Further, the IgG fraction was isolated from plasma of two aCL-positive and LA-negative patients and of two aCL-negative healthy subjects by means of protein A affinity chromatography. Each of these isolates was mixed with normal plasma, and the APC resistance was assayed; 25/162 (15.4%) patients had confirmed abnormal APC resistance. Only 1/25 (4.0%) APC resistance-positive patients and 11/137 (8.0%) APC resistance-negative patients had positive IgG- and/or IgM-aCL (p=0.5, nonsignificant). In the in vitro test system the APC resistance ratio remained unaffected after addition of normal IgG or aCL-IgG fraction in the tested normal plasma and did not deviate from the range of buffer controls. These data do not suggest any association of aCL with abnormal APC resistance. aCL-IgG fractions from aCL-positive and LA-negative plasmas do not interfere with the APC resistance test system in vitro in low concentration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01910318
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