ISSN:
1540-8183
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Coronary flow reserve (CFR) and fractional flow reserve (FFRmyo) are two guidewire-based methods currently used to assess the functional severity of coronary artery lesions. Acquiring both measurements simultaneously may provide complementary information, but would require the passage of two different guidewires and complex instrumentation for their calculation. This study assessed the procedural safety and performance of a novel personal computer-based algorithm, the SmartFlow Intravascular Processor (SFIP), which utilizes a single conventional pressure wire for obtaining simultaneous CFR and FFRmyo measurements for the assessment of coronary artery lesion severity. In 20 consecutive patients with 21 lesions, pressure-derived CFR, FFRmyo and SFIP-FFRmyo measurements were obtained during adenosine-induced hyperemia. Intravascular ultrasound and quantitative coronary angiography lesion analysis was done off-line at the Washington Core Laboratory. Mean FFRmyo was 0.83 ± 0.11, SFIP-FFRmyo was 0.86 ± 0.06, and CFR was 1.74 ± 0.46. Pairwise correlation analysis showed excellent correlation between the FFRmyo and the FFRmyo-SFIP (r2= 0.83, P 〈 0.0001) and a fair degree of relationship between the CFR and minimal lumen diameter (r2= 0.43, P = 0.07). We could not find a correlation between CFR and FFRmyo (r2= 0.22, P = 0.37), between CFR and FFR-SFIP (r2= 0.05, P = 0.86), or between the hemodynamic measurements and any of the IVUS-derived measurements. In conclusion, the SFIP is u novel algorithm for obtaining simultaneous CFR and FFRmyo that may provide valuable information for the assessment of lesion severity and clinical decision making.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1540-8183.2000.tb00310.x
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