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  • 2000-2004  (6)
  • 1975-1979  (5)
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  • 1
    Digitale Medien
    Digitale Medien
    Effect of loss of the locus coeruleus noradrenergic projections by DSP-4 treatment on striatal dopamine D2 receptors (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 85 (2003), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: DSP4 induced lesions of locus coeruleus (LC) noradrenergic neurons influence the ascending mesencephalic dopaminergic (DA) systems by reducing striatal DA turnover and inducing behavioral supersensitivity to dopaminergic drugs, the latter effect being similar to that observed after the loss of striatal DA terminals. Here a similar increase of the density of striatal DA D2 receptors (D2R) without changes in affinities of [3H]raclopride and DA was found in the case of both lesions. 6-OHDA induced DA lesions caused increases in DA-dependent activation of [35S]GTPγS, while DSP-4 had no effect on this effector system. The results indicate that an up-regulation of striatal D2R density develops after a loss of the LC noradrenergic system as also is the case after DA denervation of the striatum. In contrast, such NA lesions had no effect on D2R-G protein coupling as found after DA denervation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1471-4159.85.s2.15_9.x
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  • 2
    Digitale Medien
    Digitale Medien
    Aporphines. 14. Dopaminergic and antinociceptive activity of aporphine derivatives. Synthesis of 10-hydroxyaporphines and 10-hydroxy-N-propylnoraporphine (1976)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 19 (1976), S. 25-29 
    Details
    ISSN: 1520-4804
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/jm00223a006
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  • 3
    Digitale Medien
    Digitale Medien
    Antagonistic Oxytocin/α2-Adrenoreceptor Interactions in the Nucleus Tractus Solitarii: Relevance for Central Cardiovascular Control (2000)
    Oxford, UK : Blackwell Science Ltd
    Journal of neuroendocrinology 12 (2000), S. 0 
    Details
    ISSN: 1365-2826
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The modulation of the central cardiovascular effects of α2-adrenoceptor activation by oxytocin in the nucleus tractus solitarii has been evaluated by cardiovascular analysis and by quantitative receptor autoradiography. Microinjections in the nucleus tractus solitarii of a threshold dose of oxytocin effectively and significantly counteracted the vasodepressor and bradycardic actions of an ED50 dose of the α2−adrenoceptor agonist clonidine. The coinjection of a threshold dose of oxytocin with a threshold dose of clonidine did not produce any changes in the mean arterial pressure but a tachycardic response was observed. Receptor autoradiographical experiments showed that oxytocin (3 nM) significantly increased the Kd and Bmax values of [3H]p-aminoclonidine binding sites in the nucleus tractus solitarii compatible with a possible antagonistic interaction with the α2-adrenoceptors, and this effect was blocked by the presence of the specific oxytocin receptor antagonist 1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Orn-oxytocin. These findings suggest the existence of an antagonistic oxytocin/α2-adrenoceptor interaction in nucleus tractus solitarii that may be of relevance for the demonstrated modulation of α2−adrenoceptor induced cardiovascular responses by oxytocin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2826.2000.00571.x
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  • 4
    Digitale Medien
    Digitale Medien
    Long-Term Modulation By Postnatal Oxytocin of the α2-Adrenoceptor Agonist Binding Sites in Central Autonomic Regions and the Role of Prenatal Stress (2004)
    Oxford, UK : Blackwell Science Ltd
    Journal of neuroendocrinology 16 (2004), S. 0 
    Details
    ISSN: 1365-2826
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The aim of this work was to evaluate whether oxytocin administered in male rats subcutaneously early in life in the absence or presence of food restriction during pregnancy has life-long effects on the α2-agonist binding sites in the nucleus of the solitarii tract (NTS), in the hypothalamus and the amygdala, as evaluated by quantitative receptor autoradiography. Maternal food restriction alone increased the affinity of the α2-agonist [3H]UK14.304 binding sites exclusively in the NTS. In offspring from ad libitum fed dams, oxytocin treatment significantly increased the density of α2-agonist binding sites in the NTS and in the hypothalamus. The Kd value of the α2-agonist binding sites in the hypothalamus of these rats, but not in the other regions studied, was also significantly increased. In offspring from food-restricted dams, oxytocin treatment produced a significant increase of the Bmax values in the hypothalamus and the amygdala and the Kd value of the α2-agonist binding sites in the NTS of these rats also was selectively and significantly increased. These results suggest that a postnatal, oxytocin-induced increase of regional α2-adrenoceptor function can be seen in adulthood by a persistent, regionally selective increase in the density of central α2-adrenoceptor agonist binding sites, in the absence of an affinity change in the NTS. Such a regional increase of α2-adrenoceptor signalling in adulthood may contribute to the anti-stress action of postnatal oxytocin. By contrast, after prenatal stress, the potential increase in α2-adrenoceptor signalling takes place via selective increases of density with no changes of affinity of the α2-agonist binding sites in the hypothalamus and the amygdala.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.0953-8194.2004.01146.x
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  • 5
    Digitale Medien
    Digitale Medien
    Increased responsivity of glutamate release from the substantia nigra pars reticulata to striatal NMDA receptor blockade in a model of Parkinson's disease. A dual probe microdialysis study in hemiparkinsonian rats (2000)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 12 (2000), S. 0 
    Details
    ISSN: 1460-9568
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Dual probe microdialysis was employed in freely moving 6-hydroxydopamine (6-OHDA) hemilesioned rats to investigate the effects of blockade of N-methyl-D-aspartate (NMDA) receptors in the dorsolateral striatum on glutamate (Glu) release from the ipsilateral substantia nigra pars reticulata (SNr). Perfusion for 60 min with the NMDA antagonist dizocilpine (0.1 and 1 μm) in the dopamine (DA)-denervated striatum stimulated nigral Glu release (peak effect of 139 ± 7% and 138 ± 9%, respectively). The lower (0.01 μm) and higher (10 μm) concentrations were ineffective. In sham-operated rats, dizocilpine failed to affect nigral Glu release up to 1 μm but induced a prolonged stimulation at 10 μm (153 ± 9% at the end of perfusion). The present results show that DA-deficiency in the striatum of hemiparkinsonian rats is associated with increased responsivity of nigral Glu release to striatal NMDA receptor blockade. This suggests that changes of NMDA receptor mediated control of the striatofugal pathways occur during Parkinson's disease (PD).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1460-9568.2000.00081.x
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  • 6
    Digitale Medien
    Digitale Medien
    Intracerebral infusion of 3H-dopamine and 3H-mannitol in the striatum of halothane-anaesthetized male rats.A dual-probe microdialysis study of long-distance diffusion (2000)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 12 (2000), S. 0 
    Details
    ISSN: 1460-9568
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: This report characterizes an in vivo intracerebral long-distance diffusion model using dual-probe microdialysis. Two probes 1 mm apart were implanted into the striatum of control and 6-hydroxydopamine (6-OHDA)-lesioned halothane-anaesthetized male rats. Either tritiated dopamine (500 n m3H-DA) or mannitol (1.5 μm3H-mannitol) was infused continuously for 5 h, while samples were collected from the other probe. Samples (10 μl) were counted by liquid scintillation. For the DA-infused rats, another 10 μL was separated with high-pressure liquid chromatography (HPLC)–electrochemical detection into individual fractions containing 3,4-dihydroxy phenylacetic acid (DOPAC) and homovanillinic acid (HVA), and counted for β-decay. The total transfer of 3H-labelled compounds described the overall effect of cellular uptake, metabolism and clearance into the microcirculation, and was compared with that of an extracellular marker, 3H-mannitol. The migration reached steady-state levels, generating an equilibrium between delivery and removal from the extracellular space. The half-time of the steady-state values, t50%, was in all cases lower in 6-OHDA-treated rats compared with control. In addition, the t50% values of 3H-mannitol were lower than those following the 3H-dopamine infusion in both control or 6-OHDA-lesioned rats. However, it was not possible to detect any unmetabolized 3H-dopamine at the 1 mm distance. In conclusion, the dual-probe microdialysis approach proved to be a valid method to study in vivo diffusion and migration in the brain, and the intracerebral spread of compounds highly depends on the nature of the compound infused.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1460-9568.2000.00141.x
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  • 7
    Digitale Medien
    Digitale Medien
    Changes in dialysate concentrations of glutamate and GABA in the brain: an index of volume transmission mediated actions? (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 85 (2003), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Brain microdialysis has become a frequently used method to study the extracellular concentrations of neurotransmitters in specific areas of the brain. For years, and this is still the case today, dialysate concentrations and hence extracellular concentrations of neurotransmitters have been interpreted as a direct index of the neuronal release of these specific neurotransmitter systems. Although this seems to be the case for neurotransmitters such as dopamine, serotonin and acetylcholine, the extracellular concentrations of glutamate and GABA do not provide a reliable index of their synaptic exocytotic release. However, many microdialysis studies show changes in extracellular concentrations of glutamate and GABA under specific pharmacological and behavioural stimuli that could be interpreted as a consequence of the activation of specific neurochemical circuits. Despite this, we still do not know the origin and physiological significance of these changes of glutamate and GABA in the extracellular space. Here we propose that the changes in dialysate concentrations of these two neurotransmitters found under specific treatments could be an expression of the activity of the neurone–astrocyte unit in specific circuits of the brain. It is further proposed that dialysate changes of glutamate and GABA could be used as an index of volume transmission mediated actions of these two neurotransmitters in the brain. This hypothesis is based firstly on the assumption that the activity of neurones is functionally linked to the activity of astrocytes, which can release glutamate and GABA to the extracellular space; secondly, on the existence of extrasynaptic glutamate and GABA receptors with functional properties different from those of GABA receptors located at the synapse; and thirdly, on the experimental evidence reporting specific electrophysiological and neurochemical effects of glutamate and GABA when their levels are increased in the extracellular space. According to this concept, glutamate and GABA, once released into the extracellular compartment, could diffuse and have long-lasting effects modulating glutamatergic and/or GABAergic neurone-astrocytic networks and their interactions with other neurotransmitter neurone networks in the same areas of the brain.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1471-4159.2003.01692.x
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  • 8
    Digitale Medien
    Digitale Medien
    APPLICATIONS OF IMMUNOHISTOCHEMISTRY TO STUDIES ON MONOAMINE CELL SYSTEMS WITH SPECIAL REFERENCE TO NERVOUS TISSUES (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 254 (1975), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1975.tb29192.x
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  • 9
    Digitale Medien
    Digitale Medien
    Reevaluation of the indoleamine hypothesis of depression. Evidence for a reduction of functional activity of central 5-HT systems by antidepressant drugs (1979)
    Springer
    Journal of neural transmission 46 (1979), S. 85-103 
    Details
    ISSN: 1435-1463
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effects of antidepressant drugs on central 5-HT receptor activity were studied in rats and mice. Antidepressant drugs were evaluated for their ability to displace3H-5-HT and3H-d-LSD from membrane binding sites in the dorsal neocortex of ratsin vitro and for their ability to block 5-HTP and d-LSD induced behavioral effects in mice. The degree of blockade of head-twitches in mice produced by the antidepressants was highly correlated with their affinity for3H-d-LSD binding sites. A number of antidepressant drugs such as amitriptyline, nortriptyline, mianserine, doxepine, nomifensine and dibenzepine appear to possess marked 5-HT receptor blocking activity at some types of 5-HT receptors in brain. New antidepressant drugs such as zimelidine, which specifically inhibit 5-HT reuptake and do not block 5-HT receptor sites, may after chronic treatment also reduce the functional activity of 5-HT systems by producing adaptive changes in postsynaptic 5-HT mechanisms. Thus, a new indoleamine hypothesis of depression is presented: the therapeutic action of antidepressant drugs may in part be due to a reduced functional activity of some central 5-HT systems.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01250331
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  • 10
    Digitale Medien
    Digitale Medien
    Studies on GABA accumulation induced byγ-glutamyl-hydrazide in regions of rat brain following treatment with a tyrosine hydroxylase inhibitor and 6-hydroxy-dopamine (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 945-947 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Reduction of DA receptor activity via depletion of DA stores does not seem to influence GABA turnover in the forebrain and in the DA cell body rich region of the midbrain.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01951297
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