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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 217 (1977), S. 67-74 
    ISSN: 1432-1459
    Keywords: Tarsal tunnel syndrome ; Peroneal nerve ; M. extensor digitorum brevis ; Anterior tarsal tunnel syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das 1968 erstmals von Marinacci beschriebene vordere Tarsaltunnelsyndrom besteht in einer Kompression des N. peronaeus profundus unter dem Ligamentum cruciatum. Subjektiv werden heftige, vor allem nachts auftretende Schmerzen im Fußrückenbereich geklagt. Klinisch resultieren sensible Ausfallserscheinungen im entsprechenden Hautareal zwischen der ersten und zweiten Zehe sowie Parese und Atrophie des M. extensor digitorum brevis. Elektroneurographisch findet sich eine erhöhte distale motorische Latenz des N. peronaeus profundus, elektromyographisch ist aktive und chronische Denervierung im M. extensor digitorum brevis nachweisbar. In Fällen mit partiellem vorderen Tarsaltunnelsyndrom wird entweder nur der motorische Ast zum M. extensor digitorum brevis oder nur der sensible Anteil des N. peronaeus profundus nach der Teilung unter dem Ligamentum cruciatum komprimiert. Zwei Fälle mit vollständigem sowie ein Fall mit partiellem vorderen Tarsaltunnelsyndrom werden vorgestellt; Ätiologie, Symptomatologie, Differentialdiagnose und therapeutische Möglichkeiten werden erörtert.
    Notes: Summary The anterior tarsal tunnel syndrome, first described in 1968 by Marinacci, is characterized by a compression of the deep peroneal nerve under the inferior extensor retinaculum. The patients complaint of pains on the dorsum of the foot, especially at night. Clinically result sensory deficits in the involved area between the first and second toes as well as paresis and atrophy of the extensor digitorum brevis. The distal latency of the deep peroneal nerve is increased, the EMG shows active and chronic denervation of the extensor digitorum brevis. In cases with partial anterior tarsal tunnel syndrome only the motoric branch to the extensor digitorum brevis or only the sensory branch of the deep peroneal nerve after the division under the inferior extensor retinaculum is compressed. Two cases with complete and one with partial anterior tarsal tunnel syndrome are presented, etiology, symptomatology, differential diagnosis and therapeutic possibilities are discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1619-7089
    Keywords: [99mTc]TRODAT-1 Attention deficit hyperactivity disorder Methylphenidate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Involvement of the dopaminergic system has been suggested in patients suffering from attention deficit hyperactivity disorder (ADHD) since the symptoms can be successfully treated with methylphenidate, a potent blocker of the dopamine transporter (DAT). This study reports the findings on the status of the DAT in adults with ADHD before and after commencement of treatment with methylphenidate, as measured using [99mTc]TRODAT-1. Seventeen patients (seven males, ten females, aged 21–64 years, mean 38 years) were examined before and after the initiation of methylphenidate treatment (3×5 mg/day). All subjects were injected with 800 MBq [99mTc]TRODAT-1 and imaged 3 h p.i. Single-photon emission tomography (SPET) scans were acquired using a triple-headed gamma camera. For semiquantitative evaluation of the DAT, transverse slices corrected for attenuation were used to calculate specific binding in the striatum, with the cerebellum used as background [(STR–BKG)/BKG]. Data were compared with an age-matched control group. It was found that untreated patients presented with a significantly increased specific binding of [99mTc]TRODAT-1 to the DAT as compared with normal controls [(STR–BKG)/BKG: 1.43±0.18 vs 1.22±0.06, P〈0.001]. Under treatment with methylphenidate, specific binding decreased significantly in all patients [(STR–BKG)/BKG: 1.00±0.14, P〈0.001]. Our findings suggest that the number of DAT binding sites is higher in drug-naive patients suffering from ADHD than in normal controls. The decrease in available DAT binding sites under treatment with methylphenidate correlates well with the improvement in clinical symptoms. The data of this study help to elucidate the complex dysregulation of the dopaminergic neurotransmitter system in patients suffering from ADHD and the effect of treatment with psychoactive drugs.
    Type of Medium: Electronic Resource
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