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  • 2000-2004  (8)
  • 1975-1979  (14)
  • 1
    Electronic Resource
    Electronic Resource
    Heterotopia in microcephaly induced by cytosine arabinoside: hippocampus in the neocortex (2000)
    Springer
    Acta neuropathologica 100 (2000), S. 403-408 
    Details
    ISSN: 1432-0533
    Keywords: Key words Cytosine arabinoside ; Heterotopia ; Microcephaly ; Hippocampus ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pregnant mice were injected intraperitoneally with cytosine arabinoside (Ara-C) on days 13.5 and 14.5 of pregnancy. The brains of their offspring were studied histologically and histochemically. In addition to dysgenic microcephaly, nodular structures consisting of cells with a relatively homogeneous morphology were observed in the depths of the cerebral cortex. The cell clusters were first seen around postnatal day 4, and had a cellular continuity with the disarrayed pyramidal cell layer in the CA1 region of the hippocampus. Golgi-Cox staining showed a number of pyramidal-shaped cells in the clusters. Morphologically, they resembled the pyramidal neurons of the hippocampus. Immunohistochemical examination, using anti-serotonin or anti-tyrosine hydroxylase antibodies, also indicated similarities between the cell clusters and the pyramidal cell layer. It is, therefore, proposed that the cell clusters consisted of heterotopic pyramidal cells of the hippocampus. A few synaptic structures could already be detected in the heterotopic cell clusters on postnatal day 3 by electron microscopy. This early establishment of synaptic contact with related neurons may have caused the heterotopic localization of the pyramidal cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010000205
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  • 2
    Electronic Resource
    Electronic Resource
    Disorders produced during high-current and high-dose phosphorus ion implantation in silicon (1979)
    Springer
    Applied physics 20 (1979), S. 225-229 
    Details
    ISSN: 1432-0630
    Keywords: 61.70 ; 61.80
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Transmission electron microscopy, optical reflection and channeling effect measurements are employed to investigate disorders in 30 keV, high dose (3×1016ions/cm2) and high current (≦5 mA) phosphorus as-implanted silicon with (111), (100), and (110) orientation as a function of temperature rise (100–850°C) by the beam heating effect during implantation. Temperature rise below 400°C results in continuous amorrphous layer formation. This contrasts with results of the recovery into single crystals for temperature rise samples above 500°C, regardless of wafer orientation. Secondary defects (black-dotted defects, dislocation loops and rodlike defects) are formed in singlecrystal recovery samples, having a deeper distribution in (110) wafers and a shallower distribution in (111) and (100) wafers. Rodlike defects observed in 850°C samples are of “vacancy” type and have the largest density in (110) wafers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00886022
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  • 3
    Electronic Resource
    Electronic Resource
    Electron microscopy study of ordering of potassium ions in cubic KSbO3 (1978)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 34 (1978), S. 625-634 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Ordered and disordered states of potassium ions in (111) tunnels in the structure of cubic KSbO3 have been studied by high-resolution electron microscopy. N-beam calculations for the images of both the ordered and disordered states reproduce well the observed images. The disordered state changes into the ordered state under electron irradiation during the observations. Electron diffraction from the specimens and optical diffraction from the images show diffuse spots due to small domains of the long-range-ordered state, but no other diffuse scattering due to short-range order has been observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567739478001291
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  • 4
    Electronic Resource
    Electronic Resource
    Electron-microscope study of the crystal structures of mixed oxides in the systems Rb2O–Ta2O5, Rb2O–Nb2O5 and K2O–Ta2O5 with composition ratios near 1:3. I. Stacking characteristics of MO6 layers (1978)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 34 (1978), S. 765-773 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The crystal structures of phases, previously designated as 11L, 9L and 16L, which were commonly found in the title systems are suggested from their high-resolution two-dimensional electron-microscope images. Two types of blocks are found which are composed of five and six layers of pentavalent-metal oxide octahedra and are closely related to the pyrochlore structure. The 11L structure is of rhombohedral {\tt ABCABC} stacking of the former type of block, and the 9L structure is of hexagonal {\tt B}_{0}{\tt A}_{0}^{\prime}{\tt B}_{0}{\tt A}_{0}^{\prime} stacking of the latter type of block. The 16L structure is found to be an alternate stacking of the two types of blocks. The method of stacking of the blocks is the same for the three structures and is found to be favorable from the point of view of local charge balance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567739478001588
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  • 5
    Electronic Resource
    Electronic Resource
    Electron-microscope study of the crystal structures of mixed oxides in the systems Rb2O–Ta2O5, Rb20–Nb2O5 and K2O–Ta2O5 with composition ratios near 1:3. II. Various intergrowth phases and two-dimensional ordering of pentavalent ions (1978)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 34 (1978), S. 773-781 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: In part I, the preceding paper, structural models were proposed on the basis of high-resolution electron microscopy for phases previously designated as 11L, 9L and 16L, which were found to exist in the title systems. Two types of blocks were found, which are composed of five and six layers of octahedra. In the present paper, various intergrowth phases which are composed of the two types of blocks are described. A new notation is proposed to denote these intergrowth phases as well as the 11L, 9L and 16L structures. Two-dimensional ordering of pentavalent ions in the six-layer block is found, giving rise to diffuse scattering in electron diffraction patterns. Two-dimensional images, calculated on the basis of the proposed model, are found to reproduce the observed images.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S056773947800159X
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  • 6
    Electronic Resource
    Electronic Resource
    Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs (2002)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 420 (2002), S. 563-573 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts. There is an international collaborative effort to identify all full-length mRNA transcripts from the mouse, and to ensure that each is represented in a physical collection of clones. Here we report the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature01266
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  • 7
    Electronic Resource
    Electronic Resource
    Uptake of 5-hydroxytryptamine by chick retina (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb07069.x
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  • 8
    Electronic Resource
    Electronic Resource
    Regional variation in exhumation and strain rate of the high-pressure Sambagawa metamorphic rocks in central Shikoku, south-west Japan (2002)
    Oxford, UK : Blackwell Science Inc
    Journal of metamorphic geology 20 (2002), S. 0 
    Details
    ISSN: 1525-1314
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Regional variation in the P–T path of the Sambagawa metamorphic rocks, central Shikoku, Japan has been inferred from compositional zoning of metamorphic amphibole. Rocks constituting the northern part (Saruta River area) exhibit a hairpin type P–T path, where winchite/actinolite grew at the prograde stage, the peak metamorphism was recorded by the growth of barroisite to hornblende and sodic amphibole to winchite/actinolite grew at the retrograde stage. In the southern part (Asemi River area), rocks exhibit a clockwise type P–T path, where barroisite to hornblende core is rimmed by winchite to actinolite. The difference in P–T path could suggest a faster exhumation rate (i.e. more rapid decompression) in the southern than in the northern part. On the other hand, physical conditions of deformation during the exhumation stage have been independently inferred from microstructures in deformed quartz. Recrystallized quartz grains in rocks from the low-grade (chlorite and garnet) zones are much more stretched in the southern part (aspect ratio ≥ 4.0) than in the northern part (aspect ratio〈 4.0), indicating a higher strain rate in the former than in the latter. These facts may indicate that the exhumation and strain rates are correlated (i.e. the exhumation rate increases with increasing the strain rate). The difference in the exhumation rate inferred from amphibole zoning between the northern and southern parts could be explained by an extensional model involving normal faulting, where the lower plate can be exhumed faster than the upper plate due to the displacement along the fault. Furthermore, the model may explain the positive correlation between the exhumation and strain rates, because the lower plate tended to support more stress than the upper plate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1314.2002.00392.x
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  • 9
    Electronic Resource
    Electronic Resource
    Postnatal development of 5-hydroxytryptamine and monoamine oxidase in rat spinal cord (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 27 (1976), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb01589.x
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  • 10
    Electronic Resource
    Electronic Resource
    The roles of prostaglandin E receptor subtypes in the cytoprotective action of prostaglandin E2 in rat stomach (2000)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 14 (2000), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: To investigate the EP receptor subtype involved in the gastroprotective action of prostaglandin (PG) E2 using various EP receptor agonists in rats, and using knockout mice lacking EP1 or EP3 receptors. Methods: Male SD rats and C57BL/6 mice were used after an 18-h fast. Gastric lesions were induced by oral administration of HCl/ethanol (150 m m HCl in 60% ethanol). Rats were given various EP agonists i.v. 10 min before HCl/ethanol: PGE2, sulprostone (EP1/EP3 agonist), butaprost (EP2 agonist), 17-phenyl-ω-trinorPGE2 (17-phenylPGE2: EP1 agonist), ONO-NT012 (EP3 agonist) and 11-deoxyPGE1 (EP3/EP4 agonist). In a separate study, the effect of PGE2 on HCl/ethanol lesions was examined in EP1- and EP3-receptor knockout mice. Results: Gastric lesions induced by HCl/ethanol were dose dependently prevented by PGE2; this effect was mimicked by sulprostone and 17-phenylPGE2 and was significantly antagonized by ONO-AE-829, an EP1 antagonist. Neither butaprost, ONO-NT012 nor 11-deoxyPGE1 exhibited any protective activity against HCl/ethanol-induced gastric lesions. PGE2 caused an inhibition of gastric motility as well as an increase of mucosal blood flow and mucus secretion, the effects being mimicked by prostanoids activating EP1 receptors, EP2/EP3/EP4 receptors and EP4 receptors, respectively. On the other hand, although HCl/ethanol caused similar damage in both wild-type mice and knockout mice lacking EP1 or EP3 receptors, the cytoprotective action of PGE2 observed in wild-type and EP3-receptor knockout mice totally disappeared in mice lacking EP1 receptors. Conclusion: The gastric cytoprotective action of PGE2 is mediated by activation of EP1 receptors. This effect may be functionally associated with inhibition of gastric motility but not with increased mucosal blood flow or mucus secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2000.014s1116.x
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