ISSN:
1435-5604
Keywords:
Key words Osteogenesis imperfecta
;
Mineral
;
Composition
;
FTIR
;
31P-NMR
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Fourier transform infrared spectroscopy and 31P solid-state nuclear magnetic resonance spectroscopy were used to determine if any structural or compositional differences in osteogenesis imperfecta (OI) bone mineral could be detected that might help to explain the bone fragility observed in this disease. A previous study by Cassella et al. used an electron probe X-ray microanalytical technique to compare the calcium to phosphorus (Ca/P) molar ratios in normal bone and bone from patients with OI. It was demonstrated that bone from OI patients had a lower Ca/P molar ratio. This study demonstrated that OI bone mineral had a general hydroxyapatite structure and that isomorphous substitutions in the carbanoapatite lattice could account for the low Ca/P molar ratio.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/PL00010645
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