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  • 1
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    Rereading George Eliot : changing responses to her experiments in life (2003)
    Albany : State University of New York Press
    SUNY series in psychoanalysis and culture  
    Details
    Keywords: Eliot, George,, 1819-1880., Daniel Deronda. ; Eliot, George,, 1819-1880., Middlemarch. ; Eliot, George,, 1819-1880, Characters. ; Eliot, George,, 1819-1880, Knowledge, Psychology. ; Psychoanalysis and literature, England. ; Psychological fiction, English, History and criticism. ; Psychology in literature.
    Pages: xiii, 220 p.
    ISBN: 1-417-53141-X
    URL: http://www.netLibrary.com/urlapi.asp?action=summary&v=1&bookid=114226
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    E-Book (German National Licenses)
  • 2
    Electronic Resource
    Electronic Resource
    Subcutaneous lymphoblastic lymphomas. Expression of cellular adhesion molecules: 2 cases (2000)
    Springer
    Hematology and cell therapy 42 (2000), S. 160-164 
    Details
    ISSN: 1279-8509
    Keywords: Lymphoblasts ; Lymphoblastic ; Leukemias and lymphomas ; Adhesion molecules
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report two cases of subcutaneous lymphomas with a study of cellular adhesion molecules compared to those expressed on blasts at a later blastic phase. The striking different profile of adhesive phenotype in the two conditions is the expression of the interactions of blasts with their microenvironments. It seems that β1 integrins-dependant pathway sustains mainly the development of hematopoietic precursors in extra-medullary niches, while their contact with bone-marrow stroma and their trans-endothelial migration implicates Selectins and Immunoglobulins molecules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00282-000-0160-7
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  • 3
    Electronic Resource
    Electronic Resource
    Assisting the searcher: utilizing software agents for Web search systems (2004)
    Bingley : Emerald
    Internet research 14 (2004), S. 19-33 
    Details
    ISSN: 1066-2243
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Computer Science
    Notes: Much previous research on improving information retrieval applications has focused on developing entirely new systems with advanced searching features. Unfortunately, most users seldom utilize these advanced features. This research explores the use of a software agent that assists the user during the search process. The agent was developed as a separate, stand-alone component to be integrated with existing information retrieval systems. The performance of an information retrieval system with the integrated agent was subjected to an evaluation with 30 test subjects. The results indicate that agents developed using both results from previous user studies and rapidly modeling user information needs can result in an improvement in precision. Implications for information retrieval system design and directions for future research are outlined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/10662240410516291
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Use of query reformulation and relevance feedback by Excite users (2000)
    Bingley : Emerald
    Internet research 10 (2000), S. 317-328 
    Details
    ISSN: 1066-2243
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Computer Science
    Notes: Examines the use of query reformulation, and particularly the use of relevance feedback by users of the Excite Web search engine. A total of 985 user search sessions from a data set of 18,113 user search sessions containing 51,473 queries were examined. Includes a qualitative and quantitative analysis of 191 user sessions including more than one query, to examine patterns of user query reformulation; and second, all 804 user sessions including relevance feedback were examined. Results show limited use of query reformulation and relevance feedback by Excite users - only one in five users reformulated queries. Most relevance feedback sessions were successful. Identifies the most common pattern of searching and discusses implications for Web search system design.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/10662240010342621
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  • 5
    Electronic Resource
    Electronic Resource
    Long-term vertical changes of the anterior maxillary teeth adjacent to single implants in young and mature adults (2004)
    Oxford, UK : Munksgaard International Publishers
    Journal of clinical periodontology 31 (2004), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: To evaluate the effects of the tooth eruption process on the position of teeth adjacent to implant-borne restorations in adult patients compared to patients in their late adolescence.Subject and Methods: The sample included 28 patients divided into two groups. A “young adult” group consisting of 14 patients, aged from 15.5 to 21 years, and a “mature adult” group consisting of 14 patients, aged from 40 to 55 years. All patients presented missing anterior teeth, requiring insertion of 40 implant fixtures (16 central incisors, 12 lateral incisors, 12 canines). The implants were of the Straumann Dental Implant System, clinically and radiologically re-evaluated 1 year or more after the surgical procedure (mean interval=4.2 years). Assessment of the eruption of the adjacent teeth was performed using the implant as a stable point of reference: measurements of the different reference points were compared after implant placement and at follow-up examination.Results: In the “young adult” group, all patients showed infra-occlusion of the implant-supported crowns: the vertical step measured on radiographs varied between 0.1 and 1.65 mm. In the “mature adult” group, all patients showed a vertical difference between the teeth adjacent to the implant-supported crown and the implant: the measured step ranged from 0.12 to 1.86 mm. No difference was found in the amount of vertical eruption between male and female patients, nor according to localization of the implant.Conclusion: Mature adults can exhibit major vertical steps after anterior restorations with osseointegrated fixtures to the same extent as adolescents or “young adult” individuals with residuous growth potential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.2004.00574.x
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  • 6
    Electronic Resource
    Electronic Resource
    The Earth's mantle (2001)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 412 (2001), S. 501-507 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Seismological images of the Earth's mantle reveal three distinct changes in velocity structure, at depths of 410, 660 and 2,700 km. The first two are best explained by mineral phase transformations, whereas the third—the D″ layer—probably reflects a change in chemical ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35087500
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Ice shelves in the Pleistocene Arctic Ocean inferred from glaciogenic deep-sea bedforms (2001)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 410 (2001), S. 453-457 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It has been proposed that during Pleistocene glaciations, an ice cap of 1 kilometre or greater thickness covered the Arctic Ocean. This notion contrasts with the prevailing view that the Arctic Ocean was covered only by perennial sea ice with scattered icebergs. Detailed mapping of the ocean ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35068536
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  • 8
    Electronic Resource
    Electronic Resource
    Host-plant adaptation drives the parallel evolution of reproductive isolation (2002)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 417 (2002), S. 440-443 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Parallel evolution of similar traits in independent populations that inhabit ecologically similar environments strongly implicates natural selection as the cause of evolution. Parallel speciation is a special form of parallel evolution where traits that determine reproductive isolation evolve ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/417440a
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  • 9
    Electronic Resource
    Electronic Resource
    Molecular Mechanisms Underlying the Activity-Linked Alterations in Acetylcholinesterase mRNAs in Developing Versus Adult Rat Skeletal Muscles (2000)
    Oxford UK : Blackwell Science Ltd
    Journal of neurochemistry 74 (2000), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The molecular mechanisms underlying the activity-linked plasticity of acetylcholinesterase (AChE) mRNA levels in mammalian skeletal muscle have yet to be established. Here, we demonstrate that denervation of adult muscle induces a dramatic (up to 90%) and rapid (within 24 h) decrease in the abundance of AChE mRNAs. By contrast, denervation of 14-day-old rats leads to a significantly less pronounced reduction (50% of control) in the expression of AChE mRNAs. Assessment of the transcriptional activity of the AChE gene reveals that it remains essentially unchanged in adult denervated muscles, whereas it displays an approximately two- to three-fold increase (p 〈 0.05) in denervated muscles from 2- to 14-day-old rats. In addition, we observed a higher rate of degradation of in vitro transcribed AChE mRNAs upon incubation with protein extracts from denervated muscles. Finally, UV-crosslinking experiments reveal that denervation increases the abundance of RNA-protein interactions in the 3′ untranslated region of AChE transcripts. Taken together, these data suggest that the abundance of AChE transcripts in mature muscles is controlled primarily via posttranscriptional regulatory mechanisms, whereas in neo- and postnatal muscles, both transcriptional and posttranscriptional regulation appears critical in dictating AChE mRNA levels. Accordingly, the activity-linked transcriptional regulation of the AChE gene appears to demonstrate a high level of plasticity during muscle development when maturation of the neuromuscular junctions is still occurring.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2000.0742250.x
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  • 10
    Electronic Resource
    Electronic Resource
    Impaired fast axonal transport in neurons of the sciatic nerves from dystonia musculorum mice (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 86 (2003), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Dystonia musculorum (dt) mice suffer from a severe sensory neuropathy caused by mutations in the gene encoding the cytoskeletal cross-linker protein dystonin/bullous pemphigoid antigen 1 (Bpag1). Loss of function of dystonin/Bpag1 within neurons leads to a loss in the maintenance of cytoskeletal organization and to the development of focal axonal swellings prior to death of the neuron. In the present study, we demonstrate that neurons within the sciatic nerves of dt27J mice undergo axonal degeneration as has been previously reported for the dorsal roots. Furthermore, ultrastructural studies reveal a perturbed organization of the neurofilament and microtubule networks within the axons of sciatic nerves in dt27J mice. The disrupted cytoskeletal organization suggested that axonal transport is affected in dt mice. To address this, we assessed fast axonal transport by measuring the rate of accumulation of acetylcholinesterase (AChE) proximal and distal to a surgically introduced ligature on the sciatic nerves of normal and dt27J mice. Our findings demonstrate that axonal transport of AChE in both orthograde and retrograde directions is markedly affected, and allow us to conclude that axonal transport defects do exist in the sciatic nerves of dt27J mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2003.01861.x
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