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  • 2000-2004  (2)
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  • 1
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background The aim of our study was to assess the prevalence of rhinitis, sneezing, runny or blocked nose apart from colds in a pre-school children population and to evaluate the risk factors and relationship with allergic diseases and sensitization.Methods Eighteen nursery schools were randomly selected. The International Study of Asthma and Allergies in Childhood (ISAAC) written questionnaire (WQ) was distributed and filled by parents of pre-school children (3–5 years). The allergic sensitization to common aeroallergens and foods was evaluated by skin prick test (SPT). χ2 tests were used to compare proportions between rhinitic and non-rhinitic children.Results One thousand four hundred and two (92%) valuable questionnaires were returned. Prevalence of rhinitis in the last 12 months was 16.8%. Rhinitic children compared to non-rhinitic children presented a significant increase of diagnosed asthma (20.8% vs. 6.2%, P〈0.001), lifetime wheezing (43.2% vs. 21.6%, P〈0.001), wheezing in the last 12 months (25.0% vs. 9.4%, P〈0.001), atopic dermatitis (22.9% vs. 13.9%, P〈0.001) and allergic sensitization (29.9% vs. 13.7%, P〈0.001). Sensitization to grass pollen and house dust mites were significant risk factors for rhinitis (P〈0.01). A family history of atopy, having pets at home, male gender and greater age were significant risk factors for rhinitis, but not smoking exposure, sharing a bedroom or breastfeeding.Conclusions In pre-school children rhinitis has a strong association with wheezing symptoms, asthma and atopic dermatitis. Allergic sensitization is a risk factor for rhinitis and should be evaluated even in pre-school children.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Topical corticosteroids are beneficial in the treatment of allergic respiratory disorders; they exert effects on a number of cells involved in allergic inflammatory reactions. On the other hand, major histocompatibility complex (MHC)-unrestricted cytotoxicity (i.e., natural killer [NK] cell activity) may play a role in the inflammatory allergic reaction. The objective was to gain insight into the mechanisms of the therapeutic effects of fluticasone propionate (FP), an inhaled corticosteroid used in asthma and rhinitis therapy. Therefore, we evaluated the NK and lymphokine-activated killer (LAK) activity of effector cells in vitro treated or not with FP. Methods: Evaluations were made on peripheral blood mononuclear cells (PBMNCs), obtained from healthy volunteers (n=10) and from asthmatic atopic subjects (n=10) with allergy to Parietaria. Results: Asthmatic patients had significantly increased NK activity (P=0.0008), and interleukin (IL)-2- (P=0.0005) and interferon (IFN)-α-induced LAK activities (P=0.0005). In both groups, FP 10−7 M significantly reduced NK activity (P〈0.0001), IL-2-induced LAK activity (P〈0.0001), and IFN-α-induced LAK activity (P〈0.0001). Similar results were obtained
with FP 10−8 M. Conclusions: Since MHC-unrestricted cytotoxicity has been implicated in the development of allergen-induced eosinophilic airway inflammation, inhibition of NK and LAK activity by FP may contribute to the steroid therapeutic effect in asthma.
    Type of Medium: Electronic Resource
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