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  • 2000-2004  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Microvolume field-effect pH sensor for the scanning probe microscope (2000)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 76 (2000), S. 1072-1074 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A pH sensitive scanning probe is realized by integrating a micron-sized field-effect sensor onto a cantilever designed for an atomic force microscope. The hybrid device, called a scanning probe potentiometer (SPP), is capable of measuring pH gradients over a sample surface. The device was used to profile the pH across a reservoir of laminar streams created by fluid flow in an array of microfluidic channels of varying pH. When a single SPP scanned, a 1.5 mm reservoir in a 10-channel array, the pH profile was measured in less than 1 min with a spatial resolution of 10 μm and sensitivity of less than 0.01 pH units. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.125942
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    High-resolution micromachined interferometric accelerometer (2000)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 76 (2000), S. 3316-3318 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We demonstrate a promising type of microfabricated accelerometer that is based on the optical interferometer. The interferometer consists of surface-micromachined interdigital fingers that are alternately attached to a proof mass and support substrate. Illuminating the fingers with coherent light generates a series of diffracted optical beams. Subangstrom displacements between the proof mass and frame are detected by measuring the intensity of a diffracted beam. The structure is fabricated with a two-mask silicon process and detected with a standard laser diode and photodetector. We estimate that the minimum detectable acceleration is six orders of magnitude below the acceleration of gravity, i.e., 2 μg/Hz in a 1 Hz bandwidth centered at 650 Hz. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.126637
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Robust microfabricated field-effect sensor for monitoring molecular adsorption in liquids (2001)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 79 (2001), S. 3875-3877 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We show that a microfabricated field-effect sensor located at the terminus of a freestanding cantilever can detect surface potential changes resulting from the adsorption of charged molecules in an aqueous environment. The charge sensitive region, defined by lightly doped silicon, is embedded within the heavily doped silicon cantilever. Since both the electrical trace and sensitive region are passivated with thermally diffused silicon dioxide, the entire cantilever can be immersed in buffer solutions and cleaned with strong acids without degrading its electrical response. As an example, we demonstrate that the device can reproducibly detect adsorption of positively charged poly-L-lysine (PLL) on silicon dioxide. We also demonstrate that PLL adsorption and pH can be measured in discrete solutions by scanning the cantilever through parallel, distinct streams within a microfluidic channel array. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1423776
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Amelanotic malignant melanoma following cryosurgery for atypical lentigo maligna (2000)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 25 (2000), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cryosurgery is an alternative treatment option to surgical excision for lentigo maligna. Clinical evidence of recurrence is usually characterized by repigmentation at the treated site. We report two patients who developed amelanotic malignant melanoma following cryosurgery for a pigmented lentigo maligna. These cases illustrate the potential risk of treating lentigo maligna with cryosurgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2230.2000.00716.x
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    Paper (German National Licenses)
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