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Trans-species hair growth induction by human hair follicle dermal papillae (2001)

Jahoda, C. A. B. ; Oliver, R. F. ; Reynolds, A. J. ; [et al.]

Copenhagen : Munksgaard International Publishers

Experimental dermatology 10 (2001), S. 0

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ISSN: 1600-0625

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Abstract: A series of experimental bioassays has shown that the dermal papilla of the adult rodent vibrissa hair follicle retains unique inductive properties. In view of the many phenotypic and functional differences between specific hair follicle types, and the growing interest in hair follicle biology and disease, it remains important to establish that the human hair follicle dermal papilla has equivalent capabilities. In this study we tested the ability of human hair follicle papillae to induce hair growth when implanted into transected, athymic mouse vibrissa follicles. The implanted papillae that interacted with mouse follicle epithelium created new fibre-producing follicle end bulbs. The origin of the papillae in the recombinant structures was confirmed using laser capture microdissection and human specific gender determination by PCR. The demonstration that intact adult human dermal papillae can induce hair growth has implications for molecular analysis of basic hair growth mechanisms, particularly since the study involved common epithelial–mesenchymal signalling and recognition properties across species. It also improves the prospects for a cell-based clinical approach to hair follicle disorders.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1034/j.1600-0625.2001.100402.x

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Macrophages eyed in macular degeneration (2003)

Forrester, J V

[s.l.] : Nature Publishing Group

Nature medicine 9 (2003), S. 1350-1351

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ISSN: 1546-170X

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] The eye is an exquisitely engineered organ but, like any delicate instrument, it wears as it ages. Damage to the macula, an area rich in cone photoreceptors, leads to age-related macular degeneration (AMD) and the blurring of the world for millions of people. The notion that a low-key but ...