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  • 1
    Electronic Resource
    Electronic Resource
    MRI Observation and Mathematical Model Simulation of Water Migration in Wheat Flour Dough During Boiling (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 65 (2000), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Existing cooking rate equations fail to describe the change of moisture content profile in starchy foods during cooking. There is a need for a new model. In this paper, an experiment on water migration during boiling was performed using a slab of wheat flour dough. The moisture content profile was measured by an MRI method. The result was compared with predictions made using mathematical models. The existing mathematical model was found to predict a much more rapid change than that measured by experiment. The accuracy of the prediction was considerably improved when a new model was applied: a mathematical model based on a new concept that water migration is driven by water demand.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.2000.tb10609.x
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  • 2
    Electronic Resource
    Electronic Resource
    Histopathology of the airway epithelium in an experimental dual-phase model of bronchial asthma (2001)
    Oxford, UK : Blackwell Science, Ltd
    Clinical & experimental allergy 31 (2001), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lesions of trachea cuticles are a pathological histological characteristic of bronchial asthma. Furthermore, collected tracheal cuticles desquamated from the respiratory tract are found in patients’ sputum when asthma attacks occur or after the induction of allergen inhalation. From these facts, it is assumed that desquamation of trachea cuticle cells is a pathological symptom of bronchial asthma. However, there has not been any chronological report of desquamation of trachea cuticles through the process of bronchial asthma attacks.For this report, we made an experimental bronchial asthma model using guinea pigs, and conducted chronological examinations of trachea cuticle lesions related to pathological symptoms of bronchial asthma using a transmission electron microscope and a scanning electron microscope.The experimental asthma models were made by injection of ovalbumin into the abdominal cavity of guinea pigs. Then the airway responses to inhaled aerosolized ovalbumin were induced. The trachea were enucleated and examined under an optical microscope, a transmission electron microscope (hereafter abbreviated as TEM), and a scanning electron microscope (hereafter abbreviated as SEM) after 1, 2, 4, 8, 12, 24 h and 7 days after the immediate airway responses.Intercellular oedema of ciliated epithelium was observed in the sensitization groups immediately after the immediate airway response. SEM observation revealed increased mucus secretion and shortening of cilium. A slight case of desquamation or deciduation of ciliated epithelium was also beginning to appear. TEM observation revealed a dilation of ciliated epithelium intervals. Infiltration of eosinophilic leucocytes was already detectable beneath the ciliated epithelium. The degree of ciliated epithelium desquamation and infiltration of eosinophilic leucocytes progressed with time. When the late airway response occurred 4 hours later, eosinophilic leucocytes had increased drastically, and ciliate epithelium had desquamated to the extent that basal cells were exposed. Seven days after the immediate airway response, epithelium intercellular oedema had improved, and cilium had been reproduced.These results suggest that desquamation of epithelium caused by trachea cuticle lesions appears at an early stage of an asthma attack, owing to the contraction of the trachea, and that the damage is intensified by the infiltration of eosinophilic leucocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2001.01039.x
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  • 3
    Electronic Resource
    Electronic Resource
    Petrological evolution of a suite of spinel granulites from Vizianagram, Eastern Ghats Belt, India, and genesis of sapphirine-bearing assemblages (2003)
    Oxford, UK : Blackwell Science Inc
    Journal of metamorphic geology 21 (2003), S. 0 
    Details
    ISSN: 1525-1314
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: A suite of spinel–cordierite granulites from Viziangram, Eastern Ghats Belt, India preserve mineral assemblages and reaction textures indicative of peak metamorphic conditions of 〉1000 °C, 〉8〈10 kbar, followed successively by near isobaric cooling (down to 750–800 °C), near isothermal decompression (to 4–5 kbar), and late hydration. P–T conditions of each stage are evaluated through a combination of petrogenetic grid approach and thermobarometry. Sapphirine is developed in sillimanite-bearing acid pegmatite veins that intruded the spinel–cordierite granulite close to peak metamorphic conditions, and also in the host rock in immediate contact with the pegmatite. Both sillimanite and sapphirine in the pegmatite are considered to be magmatic phases. Field observations and textural characteristics suggest that Al-metasomatism of the spinel–cordierite granulite due to the intrusion of pegmatite was responsible for sapphirine formation in the spinel granulite.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1314.2003.00490.x
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  • 4
    Electronic Resource
    Electronic Resource
    Phase II study of concurrent chemotherapy and radiotherapy for unresectable stage III non-small-cell lung cancer: Long-term follow-up results. Japan Clinical Oncology Group Protocol 8902 (2000)
    Springer
    Annals of oncology 11 (2000), S. 445-450 
    Details
    ISSN: 1569-8041
    Keywords: chemoradiotherapy ; combined modality treatment ; non-small-cell lung cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:Although chemoradiotherapy is standard treatment forunresectable stage III non-small-cell lung cancer (NSCLC), few long-termsurvival data exist. Patients and methods:Between October 1989 and December 1991, 74patients with histologically or cytologically proven NSCLC, unresectable stageIIIA or IIIB, were entered into this study. Seventy patients were eligible andevaluable for response, toxicity, and survival analysis. Chemotherapyconsisted of cisplatin (100 mg/m2 on days 1, 29, and 57) andvindesine (3 mg/m2 on days 1, 8, 29, 36, 57, and 64). Thoracicradiotherapy was administered for two weeks (2 Gy given 10 times, fivefractions per week), and after a 14-day rest period, the previous schedule ofradiotherapy was repeated for two weeks. A 10-Gy to 20-Gy dose of radiotherapywas administered during the third cycle of chemotherapy. Results:Of the 70 evaluable patients, 1 (1.4%) hada complete response (CR) and 51 (72.9%) had a partial response (PR).The median survival time was 14.8 months, and the five-year survival rate was14.8%. The major toxicity was leukopenia (≥ grade 3, 93%).Other toxicities ≥ grade 3 included anemia (34%),nausea/vomiting (27%), alopecia (7%), thrombocytopenia(4%), and serum creatinine elevation (1%). Treatment relateddeath occurred in two patients (2.8%). One patient died of pneumoniaand pneumothorax, and the other of hemoptysis. Conclusions:Concurrent chemotherapy and radiotherapy has thepotential to provide long-term survival with acceptable toxicities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008328207137
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  • 5
    Electronic Resource
    Electronic Resource
    Association of essential hypertension in elderly Japanese with I/D polymorphism of the angiotensin-converting enzyme (ACE) gene (2000)
    Springer
    Journal of human genetics 45 (2000), S. 294-298 
    Details
    ISSN: 1435-232X
    Keywords: Key words Angiotensin-converting enzyme ; Essential hypertension ; Insertion/deletion ; Polymorphism ; Blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Recent evidence suggests that an insertion/deletion (I/D) polymorphism of the gene encoding angiotensin-converting enzyme (ACE) is associated with myocardial infarction and related cardiovascular diseases. We investigated a possible association of the ACE polymorphism with essential hypertension in a total of 263 cases/controls from among the elderly (age, over 70 years) and middle-aged (age between 30 and 60 years) Japanese population. The frequency of the I/I homozygote was significantly higher in hypertensive subjects than in controls in the elderly age group (33/57 vs 16/46; P = 0.02), but no association was observed in the middle-aged group (25/75 vs 26/85; P = 0.71). Similarly, having at least one insertion allele was associated with essential hypertension in the elderly age group (83/114 vs 46/92 in controls; P = 0.001), but not in the middle-aged group (78/150 vs 94/170; P = 0.524). These data suggest that genetic variation at the ACE locus may be associated with some determinants for blood pressure in elderly persons, and imply the involvement of the ACE insertion/deletion polymorphism in the etiology of age-related essential hypertension in the Japanese population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380070019
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  • 6
    Electronic Resource
    Electronic Resource
    Primary leiomyosarcoma of the heart subsequent to double carcinomas of the thyroid and lung (2000)
    Springer
    Heart and vessels 15 (2000), S. 100-102 
    Details
    ISSN: 1615-2573
    Keywords: Key words Primary cardiac malignant tumor ; Leiomyosarcoma ; Triple carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 63-year-old woman underwent surgical operations for left lower lung cancer and for thyroid cancer. Nine months later, a third cancer developed in her heart and this tumor was removed by open heart surgery. A pathologic study revealed that the tumor was primary leiomyosarcoma of the heart and thus independent from the previous lung and thyroid carcinomas. This case was regarded as a triple carcinoma including a primary leiomyosarcoma arising from the left atrium. Reports in the literature on primary malignant tumors of the heart are reviewed briefly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007262
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