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  • 1
    Electronic Resource
    Electronic Resource
    A novel mutation of keratin 9 in a large Chinese family with epidermolytic palmoplantar keratoderma (2004)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 150 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Epidermolytic palmoplantar keratoderma (EPPK) is an autosomal dominant inherited skin disorder characterized by diffuse yellow thickening of the skin of the palms and soles, sharply bordered with erythematous margins. Histologically and ultrastructurally, EPPK presents cytolysis of keratinocytes and abnormal aggregation of tonofilaments in the suprabasal layers of the epidermis. To date, 15 different mutations of the keratin 9 gene (KRT9) have been demonstrated to cause most cases of EPPK.Objectives  To identify the KRT9 mutation in a large Chinese family with EPPK.Methods  Denaturing high-performance liquid chromatography (DHPLC), DNA sequencing and allele-specific polymerase chain reaction (AS-PCR) were used to screen exon 1 of the KRT9 gene for sequence variations.Results  The DHPLC elution profiles of the DNA fragments amplified from the affected samples differed from those obtained from unaffected individuals, indicating that a sequence variation existed within the analysed fragment of KRT9. DNA sequencing revealed a novel insertion–deletion mutation in the exon 1 of KRT9, 497delAinsGGCT, resulting in the change of tyrosine166 to tryptophan and leucine (Y166delinsWL). AS-PCR confirmed the mutation was not a common polymorphism.Conclusions  The results suggest the molecular basis of EPPK in this Chinese family and provide further evidence that mutations in the helix initiation motif of keratin 9 underlie Chinese EPPK.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0007-0963.2004.05865.x
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  • 2
    Electronic Resource
    Electronic Resource
    Slow-time-scale magnetic fields driven by fast-time-scale waves in an underdense relativistic Vlasov plasma (2001)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 8 (2001), S. 321-328 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Slow-time-scale magnetic fields driven by fast-time-scale electromagnetic waves or plasma waves are examined from the perspective of the Vlasov–Maxwell equations for a relativistic Vlasov plasma. An equation for slow-time-scale magnetic field is obtained. The field proposed in the present paper is a result of wave–wave beating which drives a solenoidal current. The magnitude of the slow-time-scale magnetic field proposed here can be as high as 20 MG at the critical surface for a laser intensity I=1018 W/cm2 at wavelength λ0=1.05 μm. The predicted magnetic field is observed in two-dimensional particle simulations presented here. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1330200
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  • 3
    Electronic Resource
    Electronic Resource
    Weaning Chinese perch Siniperca chuatsi (Basilewsky) onto artificial diets based upon its specific sensory modality in feeding (2001)
    Oxford, UK : Blackwell Science, Ltd
    Aquaculture research 32 (2001), S. 0 
    Details
    ISSN: 1365-2109
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Chinese perch are one of the most valuable food fish in China, but the sole source of feed for intensive culture is live prey fish. Our previous studies on systematic sensory physiology revealed that this species have a mechanism for this peculiar feeding habit. In the present study, a specific training procedure was designed, and both experimental (initial body weight 171.0 g; 120 days) and commercial (initial body weight 52.4 g; 240 days) net-cage cultures were conducted to investigate the training success, growth performance and survival of the trained yearlings fed with nonlive or Oregon-type moist diet. The training successes of minced prey fish and the Oregon moist diet were 100 and 89.9%, respectively, in experimental culture, and 92.2 and 83.5% in commercial culture. In an experimental trial, the fish fed minced prey fish or the Oregon moist diet attained final body weights of 472.7 g or 344.7 g, although the specific growth rates of these groups were significantly lower than that of the fish fed live prey fish (final body weight 560.0 g). Mortality was not significantly related to dietary treatment. In commercial culture, the final body weights were as follows: 750 g on live prey fish, 705 g on minced prey fish and 651 g on the Oregon moist diet. Feed costs to produce 1 kg fish were estimated to be US$6.59 for live prey fish, US$1.76 for minced prey fish and US$2.07 for the Oregon moist diet. The results of the present study confirmed that sensory modality and associative learning appear to be critical factors in determining food discrimination of Chinese perch, indicating that both minced trash fish and Oregon-type moist diet can be substituted for live prey fish in intensive commercial production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1355-557x.2001.00006.x
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  • 4
    Electronic Resource
    Electronic Resource
    Heat capacity of hydrogenated diamond-like carbon films (2000)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 77 (2000), S. 2340-2342 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have used differential scanning calorimetry to measure the heat capacity of diamond-like carbon (DLC) film prepared by a plasma immersion ion processing method. The same calorimeter was used to measure the heat capacity of single crystal natural diamond and of high purity graphite. The amount of atomic hydrogen trapped in the DLC films was determined by elastic-recoil-detection spectrometry. The present data and literature values were used to deduce an expression for the specific heat that factors out the contribution from the sp3/sp2 bonding and from the atomic hydrogen trapped in the carbon. The data shows that the hydrogen contribution to the specific heat of carbon is independent of the sp3/sp2 bonding and amounts to about 0.63kB per hydrogen atom. We propose a simple method to determine the sp3/sp2 bonding ratio in hydrogenated DLC films based on measuring the specific heat and the hydrogen content of the sample. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1290387
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  • 5
    Electronic Resource
    Electronic Resource
    Elicitation of Both CD4+ and CD8+ T-Cell-Mediated Specific Immune Responses to HCA587 Protein by Autologous Dendritic Cells (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 60 (2004), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We recently cloned a new member of cancer/testis antigen named HCA587, which was highly expressed in human hepatocellular carcinoma (HCC) tissues. To investigate it as a potential tumour-specific target for immunotherapy, the immunogenicity of this protein, especially the ability to induce specific cellular immune responses, was evaluated in the present study. As dendritic cells (DC) are the most potent antigen-presenting cells, DC-based vaccination has recently shown marked promise for the treatment of human malignancies by immunological intervention. Here, we demonstrate that autologous DC loaded with HCA587 protein could induce specific T-cell responses in healthy individuals by in vitro stimulations. Enzyme-linked immunospot analysis for interferon-γ (IFN-γ) secretion demonstrated HCA587-specific CD8+ T cells in the antigen-stimulated peripheral blood lymphocytes, and the analysis of CD4+ T cells by proliferation assay also showed antigen-specific reactivities in normal donors. Two-colour flow cytometric analysis of surface markers and intracellular cytokine expression demonstrated that HCA587-specific cytotoxic T lymphocytes exhibited a heterogeneous CD8+/CD56+ expression, and a striking T-helper 1 cytokine bias (IFN-γhigh/IL-4low) was observed for both CD4+ and CD8+ HCA587-specific lymphocyte populations. We conclude that HCA587 is a potent immunogen that can induce CD4+ and CD8+ T-cell-mediated specific immune responses, and these findings propose HCA587 as a good candidate for the development of a therapeutic protein-based DC tumour vaccine for the treatment of HCC patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0300-9475.2004.01503.x
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  • 6
    Electronic Resource
    Electronic Resource
    Breeding of high ergosterol-producing yeast strains (2000)
    Springer
    Journal of industrial microbiology and biotechnology 25 (2000), S. 39-44 
    Details
    ISSN: 1476-5535
    Keywords: Keywords: yeast; hybridization; breeding; ergosterol; biomass
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: High ergosterol-producing yeast strains YEH-28 and YEH-56 were constructed by hybridization of two haploids with opposite mating types from different species. The fermentation conditions of hybrid strain YEH-56 were studied. The highest level of ergosterol was obtained in 30 h at 28°C and 200 rpm, when 60 ml of culture in 250-ml shake flasks was grown in fermentation medium that consisted of (per liter): 100 g glucose; 10 g peptone and 10 g yeast extract. The initial pH was adjusted to 6.0. The optimal inoculum volume was 10% (v/v). Under optimal conditions, the yield of ergosterol of YEH-28 strain is 1.96 and 1.56 times that of the parental strains YE39 and YE244, whereas that of YEH-56 is 1.98 and 1.57 times that of the parental strains YE39 and YE244, respectively. Analysis of genetic stability showed that hybrid strains YEH-28 and YEH-56 are stable genetically. Journal of Industrial Microbiology & Biotechnology (2000) 25, 39–44.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/sj.jim.7000004
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  • 7
    Electronic Resource
    Electronic Resource
    XPS Study of N-doped TiO〈sub〉x〈/sub〉 Thin Films Prepared By DC Reactive Magnetron Sputtering (2003)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 249 (Sept. 2003), p. 457-462 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/47/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.249.457.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Crystal Structure Solution of the Dark Red, Light Red and Orange Polymorphs of 5-Methyl-2-[(2-Nitro-4-Methylphenyl)Amino]-3-Thiophenecarbonitrile by High Resolution X-Ray Powder Diffraction and Simulated Annealing Techniques (2001)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 378-381 (Oct. 2001), p. 789-794 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/05/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.378-381.789.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Phylogenetic relationships of the Magnoliaceae inferred from cpDNA matK sequences (2000)
    Springer
    Theoretical and applied genetics 101 (2000), S. 925-930 
    Details
    ISSN: 1432-2242
    Keywords: Key words Magnoliaceae ; Molecular phylogeny ; Chloroplast DNA ; matK gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  The coding region of the matK gene was sequenced to infer the phylogeny of the family Magnoliaceae. Phylogenetic analyses of 21 matK sequences representing ten genera of Magnoliaceae and three outgroups suggest relationships among both subfamilies and genera. Monophyly of the subfamily Liriodendroideae (the genus Liriodendron) and the subfamily Magnolioideae is strongly supported, respectively. Within the subfamily Magnolioideae, three clades are formed: (1) the genus Magnlietia, (2) the subgenus Magnolia, and (3) the subgenus Yulania, with the genera Michelia, Paramichelia, Tsoongiodendron, Alcimandra, Kmeria, Parakmeria and Manglietiastrum. However, the genus Magnolia is shown to be a polyphyletic group, and the genus Michelia a paraphyletic group. Relatively low sequence divergences are detected among genera of the the subfamily Magnolioideae, ranging from 0.14% to 1.70%, especially in the tribe Micheliinae (0.14–0.98%). Molecular evidence from matK sequence data suggests that the phylogenetic positions and the delimitation of the eight genera Magnolia, Michelia, Tsoongiodendron, Paramichelia, Alcimandra, Kmeria, Parakmeria and Manglietiastrum need to be reconsidered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220051563
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  • 10
    Electronic Resource
    Electronic Resource
    Strong and electroweak interactions and their unification with non-commutative space-time (2003)
    Springer
    The European physical journal 28 (2003), S. 557-560 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. Quantum field theories based on non-commutative space-time (NCQFT) have been extensively studied recently. However no NCQFT model which can uniquely describe the strong and electroweak interactions has been constructed. This prevents one to make a consistent and systematic study of non-commutative space-time. In this work we construct a NCQFT model based on the trinification gauge group $SU(3)_C\times SU(3)_{{L}}\times SU(3)_{R}$ . A unique feature of this model, that all matter fields (fermions and Higgs bosons) are assigned to (anti-) fundamental representations of the factor SU(3) groups, allows us to construct a NCQFT model for strong and electroweak interactions and their unification without ambiguities. This model provides an example which allows one to make a consistent and systematic study of non-commutative space-time phenomenology. We also comment on some related issues regarding extensions to E6 and $U(3)_C\times U(3)_{L}\times U(3)_{R}$ models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epjc/s2003-01185-5
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