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  • 1
    Electronic Resource
    Electronic Resource
    Polymorphisms in IgG Fc receptor IIB regulatory regions associated with autoimmune susceptibility (2000)
    Springer
    Immunogenetics 51 (2000), S. 429-435 
    Details
    ISSN: 1432-1211
    Keywords: Key words Polymorphism ; FcγRIIB1 ; Systemic lupus erythematosus ; Germinal-center B cells ; Hyper-IgG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Autoimmune diseases involve multiple genes. While functions of these genes are largely unknown, some may be related to an intrinsic hyperresponsiveness of B cells. B-cell responses are controlled by signaling thresholds through the B-cell antigen receptor (BCR) complex. The B1 isoform of type II IgG Fc receptors (FcγRIIB1) is exclusively expressed on B cells and serves as a negative regulator for inhibiting BCR-elicited activation. Thus, its allelic variants associated with functional deficits could be examined for possible associations with susceptibility to autoimmune diseases. We found that there are three types of polymorphisms in the reported FcγRIIB transcription regulatory regions in mouse strains. Compared to normal healthy mouse strains (group III), autoimmune disease-prone strains (group I) share three deletion sites: two in the promoter region and one in the third intron. Strains (group II) that per se are not autoimmune-prone, but have potentials to accelerate autoimmune diseases share two deletion sites in the third intron: one identical to that in group I and the other unique to group II. These polymorphisms correlated well with extents of down-regulation of FcγRIIB1 expression in germinal-center B cells upon stimulation with antigens and up-regulation of IgG antibody responses. Our data imply that these FcγRIIB polymorphisms are selected evolutionarily for natural defense against pathogens, and that such polymorphisms may, in turn, form the basis of one aspect of autoimmune susceptibility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050641
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  • 2
    Electronic Resource
    Electronic Resource
    Electrical Conductivity Evaluation of Postharvest Strawberry Damage (2001)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 66 (2001), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Electrical conductivity was investigated in relation to percent pared fruit or damage indexes prepared by manually paring strawberries and stimulating bruising with a 3-dimensional vibrator. The conductivity was associated with the percent pared fruit (0 to 40%) or damage indexes (1 to 5) of strawberries, with correlation coefficients of 0.938 and 0.917 at P 〈 0.05, respectively. Furthermore, the bruising caused by the 3-dimensional vibrator resulted in increases in electrical conductivity in response to vibrating time and vibrating force. The decrease in electrical conductivity of strawberries treated with the vibrator during 2 d of storage at 25 °C and 80% relative humidity may be due to wound healing of the fruit. Electrical conductivity exhibited potential for quantitatively evaluating damage of strawberries during transportation and marketing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.2001.tb15220.x
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular classification of cutaneous malignant melanoma by gene expression profiling (2000)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 406 (2000), S. 536-540 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The most common human cancers are malignant neoplasms of the skin. Incidence of cutaneous melanoma is rising especially steeply, with minimal progress in non-surgical treatment of advanced disease. Despite significant effort to identify independent predictors of melanoma outcome, no ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35020115
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  • 4
    Electronic Resource
    Electronic Resource
    Multichannel far-infrared polarimeter-interferometer system on the MST reversed field pinch : Papers from the thirteenth topical conference on high temperature plasma diagnostics (2001)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 1077-1080 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The multichannel far-infrared (FIR) heterodyne polarimeter-interferometer system on the Madison Symmetric Torus (MST) is now operational. The combined system consists of 11 channels with variable radial and toroidal spacing. Poloidal magnetic field is determined by measuring the Faraday rotation of the FIR laser beam after propagation through the plasma by use of a phase technique. The polarimeter has 3 mrad rms noise level and 1 ms temporal resolution while the interferometer resolution is nedl=1×1012 cm−2 with time response of 1 μs. Absolute calibration of the polarimeter system is achieved by use of a rotating quartz half-wave plate. The first 11-channel polarimeter measurements from MST indicate a Faraday rotation profile in good agreement with expectations from the MSTFIT equilibrium code. Future plans to reduce the polarimeter time response from 1 ms to 10 μs will allow direct measurement of magnetic fluctuations associated with global resistive tearing modes on MST. The effect of these modes on density is already clearly resolved and provides insight into the dynamics of these structures. Improving the time response will also result in lower phase noise for both the polarimeter and interferometer. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1321744
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  • 5
    Electronic Resource
    Electronic Resource
    Evidence of spin-polarized tunneling in phase-separated manganites La1/3Sr2/3−xBaxMnO3 (0≤x≤0.67) (2001)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 79 (2001), S. 3470-3472 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Polycrystalline La1/3(Sr,Ba)2/3MnO3 (0≤x≤0.67) bulk samples were fabricated by solid-state reaction. Structural analysis by Rietveld refinement shows the phase separation while x exceeds 0.1. This phase separation leads to dramatic changes in transport properties for the samples. For the sample La1/3Ba2/3MnO3, the current–voltage and dynamic conductance characteristics demonstrate a spin-polarized tunneling behavior below ∼150 K. The spin-polarized tunneling induces a large magnetoresistance under low magnetic field. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1420531
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  • 6
    Electronic Resource
    Electronic Resource
    Comment on "Spin filtering in a magnetic–electric barrier structure" [Appl. Phys. Lett. 78, 2184 (2001)] (2002)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 80 (2002), S. 1673-1674 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1456239
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  • 7
    Electronic Resource
    Electronic Resource
    Origins of both insulator–metal transition and colossal magnetoresistance in doped manganese perovskites (2000)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 77 (2000), S. 4398-4400 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Based on experiments of both transport and paramagnetic resonance for (La1−xYx)2/3Ca1/3MnO3, the ground state above Tc and possible origins of both insulator–metal transition and colossal magnetoresistance near Tc are discussed. Modeling the system as a network of junctions, each consisting of a paramagnetic region sandwiched between two ferromagnetic domains, a phenomenological expression is proposed for resistance as a function of temperature and magnetic field. We show that the observed transport and magnetotransport phenomena can be quantitatively explained by the present model for the whole temperature range studied. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1334360
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  • 8
    Electronic Resource
    Electronic Resource
    Second-harmonic generation from silicon nanocrystals embedded in SiO2 (2001)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 78 (2001), S. 766-768 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We present observations of optical second-harmonic generation (SHG) from silicon nanocrystals embedded in SiO2. SHG sensitivity to Si/SiO2 interface states, charge on the nanocrystals, and particle density gradients is demonstrated. SHG is proven to be a powerful noncontact nondestructive diagnosis tool for characterization of Si-nanocrystal-based devices and materials. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1345825
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  • 9
    Electronic Resource
    Electronic Resource
    A novel mutation of the DSRAD gene in a Chinese family with dyschromatosis symmetrica hereditaria (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 29 (2004), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Dyschromatosis symmetrica hereditaria (DSH) is a pigmentary genodermatosis of autosomal dominant inheritance characterized by a mixture of hyperpigmented and hypopigmented macules distributed on the dorsal aspects of the hands and feet. It is caused by mutations of the RNA-specific adenosine deaminase gene. We report the identification of a Chinese family with a three-generation pedigree of DSH, in whom a novel tyrosine substitution mutation in DSRAD was demonstrated: a heterozygous nucleotide A→G transition at position 2879 in exon 10 of the DSRAD gene was detected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.2004.01548.x
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  • 10
    Electronic Resource
    Electronic Resource
    Regulatory Mechanisms of Corticotropin-Releasing Hormone and Vasopressin Gene Expression in the Hypothalamus (2004)
    Oxford, UK : Blackwell Science Ltd
    Journal of neuroendocrinology 16 (2004), S. 0 
    Details
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Tuberoinfundibular corticotropin-releasing hormone (CRH) neurones are the principal regulators of the hypothalamic-pituitary-adrenal (HPA)-axis. Vasopressin is primarily a neurohypophysial hormone, produced in magnocellular neurones of the hypothalamic paraventricular and supraoptic nuclei, but parvocellular CRH neurones also coexpress vasopressin, which acts as a second ‘releasing factor’ for adrenocorticotropic hormone along with CRH. All stress inputs converge on these hypothalamic neuroendocrine neurones, and the input signals are integrated to determine the output secretion of CRH and vasopressin. Aminergic, cholinergic, GABAergic, glutamatergic and a number of peptidergic inputs have all been implicated in the regulation of CRH/vasopressin neurones. Glucocorticoids inhibit the HPA-axis activity by negative feedback. Interleukin-1 stimulates CRH and vasopressin gene expression, and is implicated in immune-neuroendocrine regulation. cAMP-response element-binding protein phosphorylation may mediate transcriptional activation of both CRH and vasopressin genes, but the roles of AP-1 and other transcription factors remain controversial. Expression profiles of the CRH and vasopressin genes are not uniform after stress exposure, and the vasopressin gene appears to be more sensitive to glucocorticoid suppression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0953-8194.2004.01172.x
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