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  • 1
    Electronic Resource
    Electronic Resource
    Transgenic mice Fat-1 mice convert n -6 to n -3 fatty acids (2004)
    [s.l.] : Nature Publishing Group
    Nature 427 (2004), S. 504-504 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Mammals cannot naturally produce omega-3 (n-3) fatty acids — beneficial nutrients found mainly in fish oil — from the more abundant omega-6 (n-6) fatty acids and so they must rely on a dietary supply. Here we show that mice engineered to carry a fat-1 gene from the roundworm ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/427504a
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  • 2
    Electronic Resource
    Electronic Resource
    Gene transfer of the Caenorhabditis elegans n-3 fatty acid desaturase inhibits neuronal apoptosis (2002)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 82 (2002), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Previous studies have shown that n-3 polyunsaturated fatty acids (PUFAs) can exert an antiapoptotic effect on neurons. The present study was designed to investigate whether the Caenorhabditis elegans fat-1 gene encoding an n-3 fatty acid desaturase (an enzyme that converts n-6 PUFAs to corresponding n-3 PUFAs) can be expressed functionally in rat cortical neurons and whether its expression can change the ratio of n-6 : n-3 fatty acids in the cell membrane and exert an effect on neuronal apoptosis. Infection of primary rat cortical cultures with Ad-fat-1 resulted in high expression of the fat-1 gene. Lipid analysis indicated a decrease in the ratio of n-6 : n-3 PUFAs from 5.9 : 1 in control cells, to 1.45 : 1 in cells expressing the n-3 fatty acid desaturase. Accordingly, the levels of prostaglandin E2, an eicosanoid derived from n-6 PUFA, were significantly lower in cells infected with Ad-fat-1 when compared with control cells. Finally, there was a significant inhibition of growth factor withdrawal-induced apoptotic cell death in neurons expressing the fat-1 gene. These results demonstrate that expression of the fat-1 gene can inhibit apoptotic cell death in neurons and suggest that the change in the n-6 : n-3 fatty acid ratio may play a key role in this protective effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2002.01077.x
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  • 3
    Electronic Resource
    Electronic Resource
    The ORF RTL1 Transcript of Fowl Adenovirus Type-8 is Spliced and Truncated at Late Stages of the Virus Replication Cycle (2000)
    Springer
    Virus genes 20 (2000), S. 135-137 
    Details
    ISSN: 1572-994X
    Keywords: FAdV ; ORF RTL1 transcript ; splicing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two transcription products were found for the open reading frame (ORF) RTL1 located near the right terminus of the fowl adenovirus type-8 genome. The larger transcript, which was transcribed mostly during the early stage of the virus infection, contains the complete sequence (933 nucleotides) of the predicted ORF from the genomic DNA sequence encoding a 311 amino acid (aa) polypeptide. In contrast, the shorter transcript, which was more predominant at the late stage of the infection, was missing 580 nucleotides (from nucleotide 117 to 696). A premature stop codon was introduced at 210 nucleotides downstream from the start codon and the shorter transcript would encode a 70 aa polypeptide. This observation indicates that the ORF RTL1 may produce two different proteins, which function differently at different stages of the virus infection. Another possibility is that the virus may use alternative splicing as a mechanism to control the expression of the ORF, since the spliced transcript was prematurely terminated at the late stage of the infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008114430408
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of particle size on electric conducting percolation threshold in polymer/conducting particle composites (2000)
    Springer
    Journal of materials science 19 (2000), S. 377-379 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006774318019
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  • 5
    Electronic Resource
    Electronic Resource
    Pore Network Modelling of Electrical Resistivity and Capillary Pressure Characteristics (2000)
    Springer
    Transport in porous media 41 (2000), S. 263-285 
    Details
    ISSN: 1573-1634
    Keywords: network model ; electrical resistivity ; capillary pressure ; pore geometry ; wettability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Technology
    Notes: Abstract In order to model petrophysical properties of hydrocarbon reservoir rocks, the underlying physics occurring in realistic rock pore structures must be captured. Experimental evidence showing variations of wetting occurring within a pore, and existence of the so-called 'non-Archie' behaviour, has led to numerical models using pore shapes with crevices (for example, square, elliptic, star-like shapes, etc.). This paper presents theoretical derivations and simulation results of a new pore space network model for the prediction of petrophysical properties of reservoir rocks. The effects of key pore geometrical factors such as pore shape, pore size distribution and pore co-ordination number (pore connectivity) have been incorporated into the theoretical model. In particular, the model is used to investigate the effects of wettability and saturation history on electrical resistivity and capillary pressure characteristics. The petrophysical characteristics were simulated for reservoir rock samples. The use of the more realistic grain boundary pore (GBP) shape allows simulation of the generic behaviour of sandstone rocks, with various wetting scenarios. The predictions are in close agreement with electrical resistivity and capillary pressure characteristics observed in experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006612100346
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