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  • 1
    Electronic Resource
    Electronic Resource
    THE DEVELOPMENT OF HIGH-RESOLUTION IMAGING IN RADIO ASTRONOMY1 (2001)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Astronomy and Astrophysics 39 (2001), S. 457-509 
    Details
    ISSN: 0066-4146
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Physics
    Notes: Abstract Since the first radio astronomy observations in the 1930s, the angular resolution of radio telescopes has improved from tens of degrees to better than one thousandth of a second of arc. This advancement has been the result of technological innovations such as stable, sensitive, short-wavelength radio receivers, digital correlators, atomic clocks, and high-speed tape recorders, as well as the development of sophisticated image processing algorithms implemented on inexpensive, fast, digital computers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.astro.39.1.457
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  • 2
    Electronic Resource
    Electronic Resource
    A study to assess the plaque inhibitory action of a newly formulated triclosan toothpaste (2001)
    Copenhagen : Munksgaard International Publishers
    Journal of clinical periodontology 28 (2001), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background/aims: Triclosan containing toothpastes have been noted for their potential to inhibit plaque and gingival inflammation. The aim of this study was to determine whether a toothpaste containing triclosan and an enhanced fluoride system would inhibit de novo plaque formation beyond that of a non-triclosan, conventional fluoride toothpaste.Methods: This study used a 4-day plaque regrowth model in which 24 volunteers used toothpaste rinses as the only form of oral hygiene. Following a prophylaxis and a single brushing with the toothpastes, 2× daily rinsing with toothpaste slurries was used over the following 96 h.Results: After 24 h, there was no difference in plaque area between the triclosan paste and its control paste. After 96 h, a reduction in plaque score of 5% was noted for the test toothpaste compared to the control paste which was statistically significant (p=0.028). For plaque area this reduction was increased to 16%, which was also significant (p=0.006).Conclusions: These findings would appear to warrant further investigation into the potential value of the paste in inhibiting both plaque and gingivitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.2001.280113.x
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  • 3
    Electronic Resource
    Electronic Resource
    Comparative effects of quaternary ammonium mouthrinses on 4-day plaque regrowth (2000)
    Copenhagen : Munksgaard International Publishers
    Journal of clinical periodontology 27 (2000), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Quaternary ammonium compounds constitute a large group of antibacterial chemicals with a potential for inhibiting plaque and gingivitis. One compound, benzalkonium chloride (BC), may be of value, although there is a dearth of evidence to support efficacy. The aim of this study was to measure the ability of 2 BC mouthrinses (0.05% and 0.1%) to inhibit de novo plaque reformation.Method: A 4-day plaque regrowth model. For comparative purposes, a commercial mouthrinse containing cetyl pyridinium chloride (CPC) and a positive control chlorhexidine (CX) mouthrinse were also evaluated.Results: Compared to water control, a reduction in plaque scores of 52% was noted for the CX mouthrinse, 22.5% for CPC and 5% and 6% for the 2 BC rinses. For plaque area, reductions of 84%, 47%, 16% and 15% were found for CX, CPC, and the 2 BC rinses, respectively. Significant reductions in plaque area compared to the water rinse were also seen with the 2 BC rinses (p〈0.05). However, for both plaque score and plaque area, the CX and CPC rinses significantly reduced plaque compared to the BC rinses (p〈0.0001).Conclusions: These findings would suggest that the 2 benzalkonium rinses would only have a limited value at inhibiting plaque formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-051x.2000.027001037.x
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  • 4
    Electronic Resource
    Electronic Resource
    A study to assess the plaque inhibitory activity of a new triclosan mouthrinse formulation (2000)
    Copenhagen : Munksgaard International Publishers
    Journal of clinical periodontology 27 (2000), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background/aims: Toothpastes and mouthrinses containing triclosan have been shown to be of some value at inhibiting both plaque and gingivitis. However much improved activity can be obtained by the addition of other chemicals which increase substantivity or antimicrobial activity. The present study was designed to determine whether a new mouthwash formulation containing a triglyceride oil was capable of reducing plaque reformation when compared to a control rinse containing neither triclosan or oil.Methods: A total of 24 subjects took part in a double-blind, single-centre, cross-over study in which rinses were used as the only form of oral hygiene over a 4-day period. On the 1st day of each period, the subjects were given a prophylaxis to remove all plaque and calculus deposits. A single supervised rinse was taken and subsequent 2× daily rinses over the following 3 days. 24 and 96 h after the prophylaxis, the volunteers returned to the clinic, the plaque disclosed and assessed by plaque index and area. The test procedure and wash-out phase were repeated until all of the subjects had used both rinses.Results: After 24 h, a 12% reduction in plaque score and a 25% reduction in plaque area was noted for the triclosan/oil rinse compared to the control rinse; however, these reductions were not significant (p〉0.05). After 96 h, the triclosan/oil rinse failed to produce a numerical or statistical reduction in plaque whether measured by plaque score or area.Conclusions: These findings would suggest that the triclosan/oil rinse would be of little value at inhibiting dental plaque whether used alone or as an adjunct to conventional oral hygiene measures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-051x.2000.027011806.x
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  • 5
    Electronic Resource
    Electronic Resource
    A study to assess the plaque inhibitory action of a new zinc citrate toothpaste formulation (2001)
    Copenhagen : Munksgaard International Publishers
    Journal of clinical periodontology 28 (2001), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background, aims: Zinc-citrate-containing toothpastes have previously been suggested to be of value at inhibiting plaque and gingival inflammation. Present formulations have included triclosan which is thought to contribute major antibacterial/antiplaque effects. Alternative antimicrobial agents and other ingredients such as oils could help to produce equally effective formulations. The aim of this study was to determine whether zinc citrate toothpastes containing bromochlorophene and a triglyceride oil (1% and 8%) could inhibit de novo plaque formation.Methods: Toothpaste slurry rinses were used over a 96-h period by 24 volunteers, whilst omitting all other oral hygiene procedures. For comparative purposes, a conventional commercial fluoride control toothpaste was also used in this triple cross-over double blind study.Results: After 24 and 48 h, there were no statistically significant differences in plaque between the 2 test pastes and the control paste, whether assessed using a plaque index or plaque area. After 96 h, however, a significant reduction in plaque score of 10.6% and 24.2% in plaque area (both p〈0.001) was found for the zinc citrate/1% oil toothpaste compared to the control paste. In addition, at 96 h, the 8% oil toothpaste significantly reduced plaque score compared to the control paste by 4.3% (p=0.029).Conclusions: These findings would appear to warrant further investigation into the potential value of the zinc citrate/bromochlorophene/triglyceride formulation at inhibiting both plaque and gingival inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-051x.2001.028002157.x
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  • 6
    Electronic Resource
    Electronic Resource
    Clinical development and evolution in plaque removal performance of a battery powered toothbrush (2004)
    Oxford, UK : Munksgaard International Publishers
    Journal of clinical periodontology 31 (2004), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background and aim: There is growing evidence that the new generation of electric toothbrushes are more effective than manual toothbrushes. The primary aim of these studies was to compare, as an indication of the stage of development, the plaque removal properties of a prototype battery powered toothbrush with an established product. A secondary aim was to utilise the data to appraise plaque accumulation together with the patterns of removal.Method: The three studies presented used the same, single-examiner, randomised, single-blind cross-over design involving up to 24 healthy volunteers. The prototype brushes, E6500 versions s1, s2 and s3 and E8000 with head speeds of 6500 and 8000 oscillations/min were compared with a similar design marketed product (MP) with a head speed of 8800 oscillations/min. All brushes had circular brush heads with oscillating rotating actions. Subjects accumulated plaque over a 4-day period during which no oral hygiene measures were performed. On day 4, the plaque accumulation was scored by index. Subjects then used the allocated toothbrush for 2 min. This was followed by a re-scoring of the remaining plaque.Results: Studies 1 and 2 showed significantly less plaque removed by prototype E6500 (s1) and prototype E6500 (s2), respectively, than by MP. In study 3, prototype E8000 removed similar quantities of plaque to MP (approximately 65%). In contrast prototype E6500 (s3) only removed 60% of accrued plaque. Differences, however, did not reach statistical significance.Conclusions: The study methodology was appropriate to distinguish between the study toothbrushes and was furthermore able to establish a level of comparability for one of the prototype modifications with a similar MP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.2004.00596.x
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  • 7
    Electronic Resource
    Electronic Resource
    A clinical study to assess the ability of a powered toothbrush to remove chlorhexidine/tea dental stain (2004)
    Oxford, UK : Munksgaard International Publishers
    Journal of clinical periodontology 31 (2004), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: A single-center, single-blind, two-way crossover study was performed to compare the effects of an electric powered toothbrush with a conventional manual toothbrush at removing chlorhexidine/tea tooth staining.Methods: This study used 24 subjects. During the week before the study, the subjects received a prophylaxis to remove all staining, plaque and calculus deposits. On the Monday of the following week, subjects returned to the clinic to receive a further prophylaxis. Under direct supervision, they then rinsed with a 0.2% chlorhexidine mouthrinse, immediately followed by a rinse with a warm black tea solution.This cycle was repeated hourly eight times throughout the day and on the following days until the Friday. Throughout this period, volunteers omitted all other forms of oral hygiene except rinsing with the chlorhexidine mouthwash. On the Friday, the level of stain was assessed both prior to and immediately after brushing with the allocated brush with toothpaste for 1 min. This was done in an adjoining room (out of sight of the clinical scorer). Subjects were then instructed to use the toothbrush at home according to their normal oral hygiene practices. On the following Friday, subjects returned to the clinic when the stain present was re-assessed. Each subject received a thorough prophylaxis to remove all plaque calculus and staining before starting the second period of the study and again on completion of the study.Results: The study showed relatively little difference between the ability of the two brushes to remove stain at a single test brushing. However, there was some evidence that the powered brush was more effective than the manual brush in minimising stain level during the home use period, overall and in particular for gingival crescent sites.Conclusions: This study has suggested that the powered brush may become more effective at reducing dental stain, the longer the brush is used under normal home conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6979.2004.00449.x
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  • 8
    Electronic Resource
    Electronic Resource
    Clinical study to compare the effectiveness of a test whitening toothpaste with a commercial whitening toothpaste at inhibiting dental stain (2004)
    Oxford, UK : Munksgaard International Publishers
    Journal of clinical periodontology 31 (2004), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims: A single centre, randomised single-blind, three-way crossover study was performed, to compare the effect of an experimental test toothpaste with a commercially available whitening toothpaste and water control at inhibiting extrinsic stain promoted by repeated chlorhexidine/tea rinses.Methods: This study used 23 subjects. During the week before the study the subjects received a prophylaxis to remove all staining, plaque and calculus deposits. On the Monday of the following week subjects returned to the clinic to receive their rinses and to check their dentition was stain free. Under direct supervision at both 09:00 and 13:00 hours they rinsed with either a toothpaste slurry or water control that was repeated daily up to and including the following Thursday. Additionally from the Monday to the Thursday each subject rinsed with a 0.2% chlorhexidine mouthrinse, immediately followed by a rinse with a warm black tea solution. This cycle was repeated hourly eight times throughout the day and on the following days until the Friday. Throughout this period volunteers omitted all other forms of oral hygiene except rinsing with the chlorhexidine mouthwash. On the Friday the level of stain on the teeth and dorsum of tongue was assessed using the Lobene stain index for both stain area and intensity. At the end of each trial period each subject received a thorough prophylaxis to remove all plaque, calculus and staining before starting the second and third period of the study.Results: As expected appreciable amounts of extrinsic stain accumulated on the teeth over each study period. The amount of stain following use of the toothpastes and water control was least with the experimental toothpaste, followed by water control and lastly the commercial whitening paste. For all sites combined there was evidence that the experimental paste was significantly superior to both the commercial paste and water control at reducing stain area (p〈0.001), a product of stain area and intensity (p〈0.001 and 0.05, respectively) but not stain intensity (p〉0.05).Conclusions: In this stain-prevention model the use of an experimental paste showed a significant reduction in stain accumulation on the teeth compared with a (placebo) negative water control and a commercially available whitening paste. As such the experimental paste would be expected to be of benefit in controlling extrinsic dental staining.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051x.2004.00611.x
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  • 9
    Electronic Resource
    Electronic Resource
    A high incidence of Shigella-induced arthritis in a primate species: major histocompatibility complex class I molecules associated with resistance and susceptiblity, and their relationship to HLA-B27 (2000)
    Springer
    Immunogenetics 51 (2000), S. 314-325 
    Details
    ISSN: 1432-1211
    Keywords: Key words Nonhuman primate ; Spondyloarthropathy ; Reactive arthritis ; Autoimmunity ; Major histocompatibility locus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  The human major histocompatibility complex (MHC) class I gene, HLA-B27, is a strong risk factor for susceptibility to a group of disorders termed spondyloarthropathies. Rodents that express HLA-B27 develop spondyloarthropathies, implicating HLA-B27 in the etiology of these disorders. To determine whether an HLA-B27-like molecule was associated with spondyloarthropathies in nonhuman primates, we analyzed the MHC class I cDNAs expressed in a cohort of rhesus macaques that developed reactive arthritis after an outbreak of shigellosis. We identified several cDNAs with only limited sequence similarity to HLA-B27. Interestingly, one of these MHC molecules had a B pocket identical to that of HLA-B39. Pool sequencing of radiolabeled peptides bound by this molecule demonstrated that, like HLA-B27 and HLA-B39, it could bind peptides with arginine at the second position. However, extensive analysis of the MHC class I molecules in this cohort revealed no statistically significant association between any particular MHC class I allele and susceptibility to reactive arthritis. Furthermore, none of the rhesus MHC class I molecules bore a strong resemblance to HLA-B27, indicating that reactive arthritis can develop in this animal model in the absence of an HLA-B27-like molecule. Surprisingly, there was a statistically significant association between the rhesus macaque MHC A locus allele, Mamu-A*12, and the absence of reactive arthritis following Shigella infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050625
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  • 10
    Electronic Resource
    Electronic Resource
    Release of taurine in apoptotic cerebellar granule neurons in culture (2000)
    Springer
    Pflügers Archiv 439 (2000), S. 271-277 
    Details
    ISSN: 1432-2013
    Keywords: Apoptosis Cell volume Cerebellar granule neurons Osmolyte efflux Osmoregulation Sodium Taurine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Cell shrinkage is a distinctive feature of apoptotic death, but the mechanisms leading to cell volume loss are unclear at present. Activation of pathways extruding intracellular osmolytes such as K+, Cl– and organic molecules may be part of these mechanisms. This was examined in the present work measuring the release of taurine, γ-amino-butyric acid (GABA) and glutamate in cerebellar granule neurons cultured in conditions resulting in apoptotic death after 4–7 days in vitro (DIV). The basal release of [3H]taurine from cells started to increase (38%) after 3 DIV and reached a maximal enhancement (250%) at 5 DIV. The increase in taurine efflux closely followed the occurrence of apoptotic death markers such as caspase induction and chromatin condensation. The efflux of glutamate (traced as d-aspartate) and [3H]GABA also increased but notably less than that of taurine (90% and 75%, respectively) at 5 DIV. Taurine release associated with apoptosis was unaffected by 4,4'-diisothiocyanatostilbene 2,2'-disulphonic acid (DIDS) and 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB), blockers of the diffusive pathway activated during cell volume regulation in hyposmotic conditions. Taurine efflux was increased in Cl–-free (replaced by gluconate) and decreased in Na+-free media. Blockers of the energy-dependent glutamate and taurine carriers, dihydrokainate and guanidinoethane sulfonate, respectively, did not affect the release associated with apoptosis. These results implicate taurine in the mechanism of cell shrinkage during apoptosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004249900168
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