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  • 2000-2004  (5)
  • 1
    Electronic Resource
    Electronic Resource
    Melbourne, Australia : Blackwell Science Pty
    International journal of urology 8 (2001), S. 0 
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Radical prostatectomy provides the best hope for long-term survival, free of disease, for organ-confined adenocarcinoma of the prostate. The operation is performed successfully only by understanding the remarkable anatomic variability of the prostate apex and the cylindrical nature of the striated urethral sphincter. When surgical techniques are used that take into account variations at the apex, with preservation of (i) neurovascular structures; (ii) the sphincteric urethra; and (iii) the adjacent levator ani, patients can look forward to a cure and the rapid return of urinary control and erectile function.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science, Ltd
    European journal of neuroscience 18 (2003), S. 0 
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Erythropoietin (Epo) has been shown to have potent anti-apoptotic activity in central nervous system neurons in animal models of ischaemic injury. Recently, Epo and its receptor (EpoR) have been identified in the peripheral nervous system [Campana & Myers (2001), FASEB J., 15, 1804–1806]. Herein, we demonstrate that in painful neuropathy caused by L5 spinal nerve crush (SNC), therapy with recombinant human Epo (rhEpo) reduced dorsal root ganglion (DRG) apoptosis and pain behaviours. Quantification of both DRG neurons and satellite cells revealed that vehicle-treated, crush-injured DRGs had 35.5 ± 8.3% apoptotic neurons and 23.5 ± 2.36% satellite cells compared with 7.5 ± 6.3% apoptotic neurons and 6.4 ± 3.94% satellite cells in rhEpo-treated, crush-injured DRGs (P 〈 0.05). While rhEpo-treated animals were not initially protected from mechanical allodynia associated with L5 SNC, rhEpo did significantly improve recovery rates compared to vehicle-treated animals (P 〈 0.01). Systemic rhEpo therapy increased JAK2 phosphorylation, a key anti-apoptotic signalling molecule for Epo-induced neuroprotection, in DRGs after crush. Dual immunofluorescence demonstrated Epo-induced JAK2-p was associated with both neuronal and glial cells. JAK2-p was associated with NF200-positive large neurons and with smaller neurons. This population of small neurons did not colocalize with IB4, a marker of nonpeptidergic, glial derived growth factor-responsive neurons. The findings link anti-apoptosis activities of Epo/EpoR/JAK2 in DRG neurons capable of inducing protracted pain states with reductions in pain behaviours, and therefore support a role for Epo therapy in the treatment of neuropathic pain.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 42 (2001), S. 2781-2797 
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: We discuss the non-Abelian world-volume action which governs the dynamics of N coincident Dp-branes. In this theory, the branes' transverse displacements are described by matrix-valued scalar fields, and so this is a natural physical framework for the appearance of noncommutative geometry. One example is the dielectric effect by which Dp-branes may be polarized into a noncommutative geometry by external fields. Another example is the appearance of noncommutative geometries in the description of intersecting D-branes of differing dimensions, such as D-strings ending on a D3- or D5-brane. We also describe the related physics of giant gravitons. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1460-9592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Topical anesthetics may help reduce discomfort associated with procedures involving needle-puncture, such as intravenous (i.v.) insertions, in children. EMLA® cream has become a common, noninvasive therapy for topical anesthesia in children. ELA-Max® is a recently introduced topical anesthetic cream marketed as being as effective in producing topical anesthesia after a 30-min application as EMLA® is after a 60-min application. The purpose of this research was to compare ELA-Max® at 30 min with EMLA® at 60 min for providing topical anesthesia for i.v. insertions in children.Methods : Sixty children, ages 8–17 years, requiring an i.v. were randomized to receive either the 30 min application of ELA-Max® (n = 30) or the 60 min application of EMLA® (n = 30). Children rated any pain associated with the i.v. insertion using a 100-mm Visual Analog Scale (VAS). The anesthesiologist assessed the presence of blanching at the site and rated the difficulty of placing the i.v.Results : There was no clinically or statistically significant difference in pain ratings (P = 0.87) between the ELA-Max® (mean = 25.7) and the EMLA® (mean = 26.8) groups. ELA-Max® caused significantly (P = 0.04) less blanching than EMLA®, however there was no difference in the anesthesiologists’ rating of the difficulty of the i.v. placement between the groups (P = 0.73).Conclusion : Results from this study support the claim that a 30-min application of ELA-Max® (with occlusion) is as effective as a 60-min application of EMLA® (with occlusion) for producing topical anesthesia for i.v. insertion in children.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] During ischemic stroke, neurons at risk are exposed to pathologically high levels of intracellular calcium (Ca++), initiating a fatal biochemical cascade. To protect these neurons, we have developed openers of large-conductance, Ca++-activated (maxi-K or BK) potassium channels, thereby augmenting ...
    Type of Medium: Electronic Resource
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