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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 49 (2000), S. 506-512 
    ISSN: 1420-908X
    Keywords: Key words: Imidaprilat - Ramiprilat - Bradykinin - Bronchoconstriction - Hypotension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Objective: To demonstrate tissue selective bradykinin (BK) potentiating action of angiotensin converting enzyme inhibitors, we studied effects of imidaprilat and ramiprilat, active metabolites of imidapril and ramipril, respectively, on bronchoconstriction and hypotension both induced by BK in vasopressin-infused anesthetized guinea pigs.¶Methods: We measured pulmonary inflation pressure and blood pressure in vasopressin-infused anesthetized guinea pigs at the same time. BK-induced changes in pulmonary inflation pressure and blood pressure before and after the administration of ACE inhibitor were compared.¶Results: Imidaprilat and ramiprilat enhanced BK-induced hypotension comparably, and this effect was inhibited by N $ \omega $-nitro-L-arginin-methylester (L-NAME, a nitric oxide synthetase inhibitor). Although imidaprilat did not affect BK-induced bronchoconstriction, ramiprilat enhanced the bronchoconstriction significantly. SR48968, a selective NK2 receptor antagonist, significantly inhibited the enhancing effect of ramiprilat on BK-induced bronchoconstriction.¶Conclusion: These results suggest that enhancement of BK-induced hypotension by imidaprilat and ramiprilat is mediated by nitric oxide (NO), but the mediator of the enhancing action of ramiprilat on BK-induced bronchoconstriction is mainly neurokinin A.¶
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 471-472 (Dec. 2004), p. 172-177 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This study deals with the construction of network system for the production site, for the purpose of networking the machine tools as a part of the whole system. The Tele-monitoring for transformation of monitored information was studied. From the point of view of monitoring, the recognition of abnormal is very important in reducing the burden of an operator or for long-time unmanned operations. We then propose a method for the detection of abnormal in cutting process by analyzing the cutting sounds using Fourier transform, filtering, correlation analysis and statistic treatment. For the checking of tool wearing progressing, an experiment was arranged for therecognition of the sounds from a worn tip in comparison with a new one. On the detection of tipping of the cutter, a new tip is used for a long-time cutting without tool exchanging. The change of worn width and related values were compared with the original standard. It was found that the detection of tipping is possible by continuously sampling the cutting sounds and monitoring their correlation
    Type of Medium: Electronic Resource
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