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  • 2000-2004  (4)
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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillian Magazines Ltd.
    Nature 423 (2003), S. 773-777 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Protein tyrosine phosphatases regulate signal transduction pathways involving tyrosine phosphorylation and have been implicated in the development of cancer, diabetes, rheumatoid arthritis and hypertension. Increasing evidence suggests that the cellular redox state is involved in regulating ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Sedimentology 50 (2003), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: A three-dimensional numerical model of sediment transport and deposition in coarse-grained deltas is used to investigate the controls on depositional sequence variability in marine half-graben extensional basins subject to eustatic sea-level change. Using rates of sea-level change, sediment supply and fault slip reported from active rift basins, the evolution of deltas located in three contrasting structural settings is documented: (1) footwall-sourced deltas in high-subsidence locations near the centre of a fault segment; (2) deltas fed by large drainage catchments at fault tips; and (3) deltas sourced from drainage catchments on the hangingwall dip slope. Differences in the three-dimensional form and internal stratigraphy of the deltas result from variations in tilting of the hangingwall and the impact of border fault slip rates on accommodation development. Because subsidence rates near the centre of fault segments are greater than all but the fastest eustatic falls, footwall-sourced deltas lack sequence boundaries and are characterized by stacked highstand systems tracts. High subsidence and steep bathymetry adjacent to the fault result in limited progradation. In contrast, the lower subsidence rate settings of the fault-tip and hangingwall dip-slope deltas mean that they are subject to relative sea-level fall and associated fluvial incision and forced regression. Low gradients and tectonic tilting of the hangingwall influence the geometry of these deltas, with fault-tip deltas preferentially prograding axially along the fault, creating elongate delta lobes. In contrast, broad, sheet-like delta lobes characterize the hangingwall dip-slope deltas. The model results suggest that different systems tracts may be coeval over length scales of several kilometres and that key stratal surfaces defining and subdividing depositional sequences may only be of local extent. Furthermore, the results highlight pitfalls in sequence-stratigraphic interpretation and problems in interpreting controlling processes from the preserved stratigraphic product.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Sedimentology 47 (2000), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: This study focuses on Miocene sedimentation and stratigraphic evolution in a major transfer zone at the northern tip of the Thal Fault segment, Gulf of Suez. The succession generally shoals upwards from offshore mudstone containing pro-delta turbidites, into conglomeratic delta foresets and topsets, with sandstone-dominated shoreface facies coexisting laterally. Despite this upward shoaling, key stratal surfaces marking abrupt changes in relative sea-level allow the succession to be divided into four stratal units. The stacking pattern of the stratal units suggests an initial relative sea-level rise that generated a major marine flooding surface. A relative sea-level fall followed, resulting in widespread exposure and incision. During the ensuing relative sea-level rise a lowstand coarse-grained delta and coeval shoreface succession prograded several kilometres basinward. The stratigraphic development of the transfer zone delta is in marked contrast to that of aggradationally stacked deltas that occur near the centre of the Baba-Sidri fault segment, further south. At the transfer zone, low rates of subsidence and accommodation development coupled with a high sediment supply derived from a large fault tip drainage catchment have produced a strongly progradational delta subject to marked changes in relative sea-level. In the fault centre location, however, higher rates of accommodation development coupled with lower rates of sediment supply from footwall catchments have produced aggradationally stacked deltas. The results from this study have implications for sequence stratigraphic models and hydrocarbon exploration within extensional basins.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature structural biology 8 (2001), S. 1025-1030 
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The 2.7 Å structure of wheat HSP16.9, a member of the small heat shock proteins (sHSPs), indicates how its α-crystallin domain and flanking extensions assemble into a dodecameric double disk. The folding of the monomer and assembly of the oligomer are mutually interdependent, involving ...
    Type of Medium: Electronic Resource
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