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  • 2000-2004  (8)
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    BJOG 109 (2002), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To examine the effect of counselling and relaxation intervention on psychological symptoms in patients with gynaecological cancer between the post-operative period and the six-week review.Design Randomised controlled trial.Participants Fifty-three patients with gynaecological cancer.Setting Three Australian tertiary referral hospitals.Methods Fifty-three patients were randomised to control or intervention and completed the baseline Hospital Anxiety and Depression Scale (HADS) and General Health Questionnaire-28 (GHQ-28) questionnaires. The intervention consisted of a relaxation and counselling session performed by a senior doctor. Follow up questionnaires were completed at six weeks. Demographic and tumour data were collated independently.Results Complete data were available on 50 patients. There were no significant differences in demographic, social support or tumour characteristics between the two groups. Multivariate analysis determined that only the intervention and baseline score were significant predictors of outcome. The intervention was associated with a significant reduction in total HADS score (P= 0.002). The reduction was seen in both anxiety and moderate depression subscales (P= 0.001 and P= 0.02). The intervention was also associated with a significant reduction in total GHQ-28 score and in three of the four subscale scores (somatisation, anxiety and personality development; all P 〈 0.02). However, no significant difference was found in the fourth subscale of major depression.Conclusion A relaxation and counselling intervention performed by a treating doctor reduces psychological symptoms in women with a new diagnosis of gynaecological cancer.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    BJOG 108 (2001), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To assess the accuracy of intra-operative frozen section reports at identifying the features of high risk uterine disease compared with final histopathology.Design Retrospective study.Methods The records of 460 patients with uterine cancer registered with the Queensland Centre for Gynaecological Cancer between January 1, 1996 and December 31, 1998 were reviewed. Intra-operative frozen section was undertaken in 260 patients with endometrial adenocarcinoma. Frozen section pathology was compared with the final histopathology reports. Inter-observer reliability was assessed using percentage agreement and kappa statistics. Clinical notes were also reviewed to determine if errors resulted in sub-optimal patient care.Results Respectively, tumour grade and depth of myometrial invasion were accurately reported in 88.6% of cases (expected 61.5%, Kappa 0.70) and 94.7% (expected 53.8%, Kappa 0.89). Errors were predominantly attributable to difficulties with respect to the interpretation of tumour grade. The error resulted in the patient receiving sub-optimal surgical management in only 11 cases (5.3%)Conclusion Frozen section is accurate at identifying the features of high risk uterine disease in the setting of endometrial cancer and can play an important role in directing primary operative management.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 408 (2000), S. 768-768 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sir Your report (Nature 407, 276; 2000) about the World Bank giving higher priority to science was a welcome reminder that, unfortunately, national and international 'development' organizations have given short shrift to the ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Westerville, Ohio : American Ceramics Society
    Journal of the American Ceramic Society 83 (2000), S. 0 
    ISSN: 1551-2916
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Cylindrical, stand-alone tubes of plasma-sprayed alumina were tested in compression in the axial direction at room temperature, using strain gauges to monitor axial and circumferential strains. The primary compression-loading profile used was cyclic loading, with monotonically increased peak stresses. Hysteresis was observed in the stress–strain response on unloading, beginning at a peak stress of 50 MPa. The modulus decreased as the maximum applied stress increased. The stress–strain response was only linear at low stresses; the degree of nonlinearity at high stresses scaled with the stress applied. One-hour dwells at constant stress at room temperature revealed a time-dependent strain response. Using transmission electron microscopy and acoustic emission to investigate deformation mechanisms, the stress–strain response was correlated with crack pop-in, growth, and arrest. It is proposed that the numerous defects in plasma-sprayed coatings, including porosity and microcracks, serve as sites for crack nucleation and/or propagation. As these small, nucleated cracks extend under the applied stress, they propagate nearly parallel to the loading direction along interlamellae boundaries. With increasing stress, these cracks ultimately link, resulting in catastrophic failure.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Westerville, Ohio : American Ceramics Society
    Journal of the American Ceramic Society 83 (2000), S. 0 
    ISSN: 1551-2916
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A unique, all-ceramic material capable of nonbrittle fracture via crack deflection and delamination has been mechanically characterized from 25° through 1400°C. This material, fibrous monoliths, was comprised of unidirectionally aligned 250 μm diameter silicon nitride cells surrounded by 10 to 20 μm thick boron nitride cell boundaries. The average flexure strengths of fibrous monoliths were 510 and 290 MPa for specimens tested at room temperature and 1300°C, respectively. Crack deflection in the BN cell boundaries was observed at all temperatures. Characteristic flexural responses were observed at temperatures between 25° and 1400°C. Changes in the flexural response at different temperatures were attributed to changes in the physical properties of either the silicon nitride cells or boron nitride cell boundary.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Westerville, Ohio : American Ceramics Society
    Journal of the American Ceramic Society 83 (2000), S. 0 
    ISSN: 1551-2916
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The influence of spray parameters on the microstructure and flexural strength of plasma-sprayed alumina was investigated. Coatings were applied using a small-particle plasma spray (SPPS) method, which is a recently patented process that allows submicrometer-sized powders to be sprayed. Using identical starting powders, coatings that were produced using two distinctly different spray conditions exhibited significant differences in both microstructure and strength. Scanning electron microscopy investigations of single lamellae (or splats) revealed that, for one spray condition, melted alumina particles will splash when they contact the substrate. The morphology of the splats that comprised the subsequent layers of the coating also were highly fragmented and thinner than lamellae formed under “nonsplashing” spray conditions. The surface roughness was strongly dependent on the morphology of the lamellae; increased roughness was noted for fragmented splats. Thick coatings that were comprised of splashed splats developed a unique microstructural feature that was responsible for the observed increase in roughness. These microstructural differences greatly influenced the flexure strength, which varied from 75 ± 21 MPa for the nonsplashing spray condition to 17 ± 2.4 MPa for the “splashing” condition.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Westerville, Ohio : American Ceramics Society
    Journal of the American Ceramic Society 87 (2004), S. 0 
    ISSN: 1551-2916
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A plasma-sprayed 7-wt%-yttria-stabilized zirconia stand-alone tube was incrementally loaded in uniaxial compression inside a scanning electron microscope. Micrographs taken at each increment showed cracks perpendicular to the applied load to have partially closed and cracks parallel to the applied load to have opened. New cracks were observed to nucleate and then propagate in a direction parallel to the applied load.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-5176
    Keywords: cyanobacteria ; bioactive compounds ; allelopathy ; calothrixin ; hapalindole ; alkaloids ; Fischerella ; Calothrix
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The alkaloids 12-epi-hapalindole E isonitrile,isolated from the cyanobacterium Fischerellasp., and the indolophenanthridine calothrixin A, fromCalothrix sp., were characterized in terms oftheir ability to kill several organisms and celltypes, and their biochemical modes of action. Bothcompounds inhibited RNA synthesis, and consequentlyprotein synthesis, in Bacillus subtilis. Calothrixin A also inhibited DNA replication, thehapalindole having little effect on this process. Measurements of in vitro RNA synthesis confirmedthe in vivo results and suggested that bothcompounds inhibit RNA polymerase directly; the degreeof inhibition was independent of the DNAconcentration, but strongly dependent on thepolymerase concentration.
    Type of Medium: Electronic Resource
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