ISSN:
1434-0879
Keywords:
Key words Bladder cancer
;
FISH method
;
Chromosomal abnormality
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Although a bladder cancer-specific abnormality in chromosomes or genes has not been reported, chromosomal regions that tend to become abnormal have been recognized. In this study, we investigated abnormalities in chromosomes 8 and 11. There were 27 patients with bladder cancer, 16 males and 11 females, who participated in this study. Abnormalities in chromosomes 8 and 11 were investigated by the fluorescence in situ hybridization (FISH) method. Probes used in this study were chromosome 8α-satellite and chromosome 11α-satellite (Oncor Co.). Of 27 cases, 15 cases were positive for chromosome 8 (55.6%) and ten cases were positive for chromosome 11 (37.0%). Since the FISH method detects chromosomal abnormality by the number of signals generated in cancer cells, this method is objective and simple and thus may be applicable in clinical practice.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002409900077
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