Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 2000-2004  (2)
  • 1
    Electronic Resource
    Electronic Resource
    A randomized study of alpha-interferon plus ribavirin for 6 months or 12 months for the treatment of chronic hepatitis C in patients with bleeding disorders (2002)
    Oxford UK : Blackwell Science Ltd
    Haemophilia 8 (2002), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Little is known about the optimal treatment in patients with chronic hepatitis C virus (HCV) who were infected by pooled plasma products. The aim of our study was to compare the efficacy of 6 and 12 months of combination therapy with interferon α-2b and ribavirin in patients with bleeding disorders and chronic HCV. In a randomized open study, 61 patients with haemophilia or von Willebrand disease received treatment with a combination of interferon α-2b and ribavirin at standard dosage for 6 or 12 months. Follow-up was done with analysis of HCV RNA after an additional 6 months. The prevalence of HCV genotype 1 was 67%. Overall, sustained viral response was achieved in 41%; 13 of 30 patients (43%) treated for 6 months vs. 12 of 31 patients (39%) treated for 12 months. The rate of sustained response was 22% in those with HCV genotype 1 and 80% in other genotypes (100% in genotype 2), with no difference between the treatment durations. The number of early discontinuations due to side-effects was 3 and 9, respectively. The study was stopped prematurely due to introduction of a more effective regimen, and the numbers are not sufficient to state equality. We conclude that the efficacy and safety of combination therapy against chronic hepatitis C in patients infected by pooled plasma products is similar to that observed in other populations. Six months of therapy seems sufficient in the case of HCV genotype 2. For other genotypes, the decision regarding duration of therapy has to be based on the tolerance of the individual patient together with experiences from other studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2516.2002.00629.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Pressure signal transmission of five commercially available oesophageal balloon catheters (2000)
    Springer
    Intensive care medicine 26 (2000), S. 462-465 
    Details
    ISSN: 1432-1238
    Keywords: Key words Phrenic nerve stimulation ; Work of breathing ; Oesophageal pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Five commercially available oesophageal balloon catheters (OBCs) were tested to evaluate the accuracy in transmitting fast-changing pressure signals which can be observed, for example, during phrenic nerve stimulation.¶Setting: Research laboratory of a university hospital.¶Method: The OBCs tested varied in length (900–1390 mm) and inner diameter (0.9–1.5 mm) as well as in balloon material [latex or polyvinyl-chloride (PVC)]. A 180-cm tube served as a control. A sudden pressure drop was generated by the explosion of a pressurized latex balloon. The time between the pressure drop and 75, 50, 25 and 10 % of the maximal pressure was measured.¶Results: The time intervals required to transduce a pressure drop of 90 % varied between the different OBCs from 85 to 476 ms(control 32 ms). Transmission time was lower in OBCs with a larger inner diameter. Shortening the OBCs resulted in a further decrease in transmission time.¶Conclusion: The type of OBC used has an impact on signal processing. An OBCs with a short transmission time should be chosen, especially if fast pressure changes are to be evaluated such as during phrenic nerve stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340051182
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...